公开(公告)号：US20060247314A1

公开(公告)日：2006-11-02

申请号：US11145359

申请日：2005-06-03

Applicant: Xiaoli Chen ,  Keith Demarest ,  Jung Lee ,  Jay Matthews ,  Philip Rybczynski

Inventor： Xiaoli Chen ,  Keith Demarest ,  Jung Lee ,  Jay Matthews ,  Philip Rybczynski

IPC: A61K31/195 ,  C07C313/24

CPC classification number: C07C323/52 ,  C07C275/34 ,  C07C323/61 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10

Abstract: The invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, dyslipidemia.

Abstract translation: 本发明的特征在于具有四氢化萘和茚满化合物，含有它们的组合物，以及使用它们作为PPARα调节剂治疗或抑制例如血脂异常进展的方法。

公开(公告)号：US07125878B2

公开(公告)日：2006-10-24

申请号：US10430000

申请日：2003-05-06

Applicant: Han-Cheng Zhang ,  Gee-Hong Kuo ,  Bruce E. Maryanoff ,  Hong Ye ,  David O'Neill ,  Lan Shen ,  Keith Demarest ,  Bruce R. Conway ,  David F. McComsey

Inventor： Han-Cheng Zhang ,  Gee-Hong Kuo ,  Bruce E. Maryanoff ,  Hong Ye ,  David O'Neill ,  Lan Shen ,  Keith Demarest ,  Bruce R. Conway ,  David F. McComsey

IPC: A61K31/495 ,  C07D241/02 ,  C07D403/04

CPC classification number: C07D471/04

Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.

公开(公告)号：US20060205763A1

公开(公告)日：2006-09-14

申请号：US11436000

申请日：2006-05-17

Applicant: Han-Cheng Zhang ,  Gee-Hong Kuo ,  Bruce Maryanoff ,  Hong Ye ,  David O'Neill ,  Lan Shen ,  Keith Demarest ,  Bruce Conway ,  David McComsey

Inventor： Han-Cheng Zhang ,  Gee-Hong Kuo ,  Bruce Maryanoff ,  Hong Ye ,  David O'Neill ,  Lan Shen ,  Keith Demarest ,  Bruce Conway ,  David McComsey

IPC: A61K31/4745 ,  C07D471/02

CPC classification number: C07D471/04

Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.

公开(公告)号：US20060058393A1

公开(公告)日：2006-03-16

申请号：US11226179

申请日：2005-09-14

Applicant: Alan DeAngelis ,  Keith Demarest ,  Gee-Hong Kuo ,  Patricia Pelton ,  Aihua Wang ,  Rui Zhang

Inventor： Alan DeAngelis ,  Keith Demarest ,  Gee-Hong Kuo ,  Patricia Pelton ,  Aihua Wang ,  Rui Zhang

IPC: A61K31/192 ,  C07C323/22

CPC classification number: C07C323/60 ,  C07C59/68 ,  C07C323/20

Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.

公开(公告)号：US20050191668A1

公开(公告)日：2005-09-01

申请号：US11036746

申请日：2005-01-14

Applicant: Lubing Zhou ,  Ellen Cryan ,  Keith Demarest

Inventor： Lubing Zhou ,  Ellen Cryan ,  Keith Demarest

IPC: A61K38/00 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/68

CPC classification number: C12Q1/6883 ,  C12Q2600/158

Abstract: This invention features the identification of novel target genes for peroxisome proliferator-activated receptors alpha (PPARα) in human, and their use in treating or monitoring the treatment of metabolic abnormalities, as well as in identifying compounds useful for treating metabolic abnormalities.

Abstract translation: 本发明特征在于鉴定人类中过氧化物酶体增殖物激活受体α（PPARα）的新靶基因，以及它们在治疗或监测代谢异常的治疗中的用途，以及鉴定用于治疗代谢异常的化合物。