公开(公告)号：US20210369614A1

公开(公告)日：2021-12-02

申请号：US17399320

申请日：2021-08-11

Applicant: LEMONEX INC.

Inventor： Cheolhee WON

IPC: A61K9/16 ,  A61K31/203 ,  A61K31/44 ,  A61K31/4745 ,  A61K31/704 ,  A61K31/711 ,  A61K31/713 ,  A61K38/17 ,  A61K38/46 ,  A61K39/395

Abstract: A porous silica particles according to an embodiment of the present disclosure includes a plurality of pores with a diameter of 5 nm to 100 nm. The porous silica particles have particular physical properties, can deliver all various drugs by a supported amount in a sustained manner, and can be parenterally administered.

公开(公告)号：US20190071314A1

公开(公告)日：2019-03-07

申请号：US16122872

申请日：2018-09-05

Applicant: LEMONEX INC. ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

Inventor： Dal-Hee MIN ,  Cheolhee WON ,  Sejin PARK ,  Seongchan KIM

IPC: C01B37/02 ,  C12N5/00 ,  A61K9/50 ,  A61K9/51 ,  B01J13/02 ,  B82Y5/00

Abstract: A composition includes porous silica particles to carry a cell fate modulating factor therein. A method for modulating cell fate includes treating various cells with the composition. The cell fate modulating factor is delivered to a stable target receptor, toxicity to subject cells for delivery may be reduced, a fate of the subject cells can be controlled through sustained release of at least 99 wt. % of the cell fate modulating factor.

公开(公告)号：US20170172923A1

公开(公告)日：2017-06-22

申请号：US15328121

申请日：2015-03-31

Applicant: Cheolhee WON ,  LEMONEX INC.

Inventor： Cheolhee WON

IPC: A61K9/14 ,  A61K47/02

CPC classification number: A61K9/143 ,  A61K9/145 ,  A61K9/16 ,  A61K39/395 ,  A61K47/02 ,  A61K47/40 ,  B82Y5/00

Abstract: A composition for delivering a bioactive material include a porous silica nanoparticle containing pores with an average pore diameter ranging from 1 nm to 100 nm, at least one of (i) a functional group which binds to the pore surface of the porous silica nanoparticle and gives the pore surface a negative charge or a positive charge, (ii) a ligand which binds to the pore surface of the porous silica nanoparticle and specifically binds to the bioactive material, and (iii) a combination of the functional group and the ligand, and a bioactive material having a size to be accommodated within the pores of the porous silica nanoparticle, the bioactive material bound to said at least one of the functional group and the ligand bound to the pore surface of the mesoporous silica nanoparticle and accommodated within the pores of the porous silica nanoparticle.