公开(公告)号：US20190071314A1

公开(公告)日：2019-03-07

申请号：US16122872

申请日：2018-09-05

Applicant: LEMONEX INC. ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

Inventor： Dal-Hee MIN ,  Cheolhee WON ,  Sejin PARK ,  Seongchan KIM

IPC: C01B37/02 ,  C12N5/00 ,  A61K9/50 ,  A61K9/51 ,  B01J13/02 ,  B82Y5/00

Abstract: A composition includes porous silica particles to carry a cell fate modulating factor therein. A method for modulating cell fate includes treating various cells with the composition. The cell fate modulating factor is delivered to a stable target receptor, toxicity to subject cells for delivery may be reduced, a fate of the subject cells can be controlled through sustained release of at least 99 wt. % of the cell fate modulating factor.

公开(公告)号：US20210102241A1

公开(公告)日：2021-04-08

申请号：US17016691

申请日：2020-09-10

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

Inventor： Dal-Hee MIN ,  Yeajee YIM

IPC: C12Q1/6823 ,  C12Q1/6841 ,  C12N15/113 ,  C12Q1/6876 ,  C12N9/22

Abstract: A method for introducing a foreign gene into a cell according to an embodiment of the present disclosure can easily identify foreign gene introduction by detecting whether there is fluorescent emission or not, and can reduce influence of additional elements other than a target gene since any reporter gene or selectable marker is not required. Further, the inventive method does not need an additional sampling process and therefore may implement a relatively accurate and simple screening process.

公开(公告)号：US20210085789A1

公开(公告)日：2021-03-25

申请号：US16603359

申请日：2018-04-09

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

Inventor： Dal-Hee MIN

IPC: A61K41/00 ,  A61K9/70 ,  A61K31/519 ,  A61K33/38 ,  A61K33/34 ,  A61K33/242 ,  A61K33/243 ,  A61K33/26 ,  A61K33/32 ,  A61K33/24 ,  A61P35/00

Abstract: A composition for photodynamic therapy or diagnosis includes a photosensitizer-metallic nanosheet complex. In a case of using a folic acid-loaded metallic nanosheet, a poorly-soluble photosensitizer may be effectively loaded, thus to increase solubility and the photosensitizer may not be degraded in blood during in vivo administration but may maintain stability, thereby inhibiting imprudent release of the photosensitizer. Further, the nanosheet entered into the cancer cells may be substantially completely degraded by glutathione (GSH) present at a high concentration in the cancer cells. Therefore, it is expected that using the photosensitizer-metallic nanosheet complex may drastically reduce a dose of an anticancer agent while having little side effects and may enable effective treatment, thereby achieving a novel concept in anticancer therapeutic effects.

公开(公告)号：US20210137922A1

公开(公告)日：2021-05-13

申请号：US16476220

申请日：2018-01-08

Applicant: LEMONEX INC.

Inventor： Jae Ho LEE ,  Dal-Hee MIN ,  Cheolhee WON

IPC: A61K31/506 ,  A23L33/10 ,  A61K31/337 ,  A61K31/475 ,  A61K31/165 ,  A61K31/343 ,  A61K33/243 ,  A61P35/04

Abstract: A method for treatment of cancer selected from the group consisting of metastatic ovarian cancer, endometrial cancer, and breast cancer includes administering a composition comprising a compound represented by Formula 1, a pharmaceutically acceptable salt thereof to a subject in need thereof: The composition can efficiently kill cancer cells present in a spheroid form, thereby being usefully applied as novel medicament for metastatic ovarian cancer, endometrial cancer or breast cancer.

公开(公告)号：US20180306718A1

公开(公告)日：2018-10-25

申请号：US15765409

申请日：2016-06-15

Applicant: LEMONEX INC.

Inventor： Cheolhee WON ,  Dal-Hee MIN

IPC: G01N21/64 ,  C12N15/115 ,  C12N1/20 ,  C08B37/08 ,  G01N33/574

Abstract: A quencher containing water-soluble polymer-conjugated nanomaterial effectively quenches the fluorescence of a fluorescent material-conjugated probe. In addition, a composition including the quencher and a fluorescent material-conjugated probe can detect a target material existing at a low concentration, and thus can be favorably used as a composition or kit for providing information necessary for the detection of a biomaterial or the diagnosis of a disease.