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    Substituted 3,4-dihydropyrido[1,2-a]pyrimidines
    34.
    发明授权
    Substituted 3,4-dihydropyrido[1,2-a]pyrimidines 失效
    取代3,4-二氢吡啶并[1,2-a]嘧啶

    公开(公告)号：US07230103B2

    公开(公告)日：2007-06-12

    申请号：US10411390

    申请日：2003-04-11

    Applicant: Matthias Gerlach ,  Corinna Maul ,  Utz-Peter Jagusch

    Inventor： Matthias Gerlach ,  Corinna Maul ,  Utz-Peter Jagusch

    IPC: A01N43/90 ,  A61K31/519

    CPC classification number: C07D471/04

    Abstract: Substituted 3,4-dihydropyrido[1,2-a]pyrimidines of formula I and processes for the production thereof Also disclosed are substance libraries and pharmaceutical compositions containing the compound, and methods of treatment for pain, urinary incontinence, pruritus, tinnitus and/or diarrhoea using the pharmaceutical composition.

    Abstract translation: 式I的取代的3,4-二氢吡啶并[1,2-a]嘧啶及其生产方法还公开了含有该化合物的物质文库和药物组合物，以及治疗疼痛，尿失禁，瘙痒，耳鸣和/ 或使用该药物组合物的腹泻。

    Substituted indole Mannich bases
    36.
    发明授权
    Substituted indole Mannich bases 失效
    取代的吲哚曼尼希基地

    公开(公告)号：US07091220B2

    公开(公告)日：2006-08-15

    申请号：US10168985

    申请日：2000-12-20

    Applicant: Matthias Gerlach ,  Corinna Maul

    Inventor： Matthias Gerlach ,  Corinna Maul

    IPC: A61K31/445 ,  C07D209/42 ,  C07D209/14

    CPC classification number: C07D209/42 ,  C07D209/14

    Abstract: The present invention relates to substituted indole Mannich bases, processes of preparing substituted indole Mannich base, a medicament containing the same, and a pharmaceutical composition containing the same.

    Abstract translation: 本发明涉及取代的吲哚曼尼希碱，制备取代的吲哚曼尼希碱，制备取代的吲哚曼尼希碱的方法，含有它们的药物和含有它们的药物组合物。

    Substituted pyrrole mannich bases to combat pain and allergic reactions
    37.
    发明授权
    Substituted pyrrole mannich bases to combat pain and allergic reactions 失效
    取代的吡咯甘露醇碱可以抵抗疼痛和过敏反应

    公开(公告)号：US07034018B2

    公开(公告)日：2006-04-25

    申请号：US10168964

    申请日：2000-12-20

    Applicant: Matthias Gerlach ,  Corinna Maul

    Inventor： Matthias Gerlach ,  Corinna Maul

    IPC: A61K31/535 ,  C07D207/00

    CPC classification number: C07D207/335 ,  C07D401/06 ,  C07D407/04

    Abstract: The invention relates to substituted pyrrole Mannich bases of general formula (I), wherein R1=H, a C1-10-alkyl-, aryl, a heteroaryl- or an aryl, heteroaryl-, CN, Br—, Cl or OH radical bound by a C1-6 alkylene group, R2=CH(R4)N(R5)(R6), R3, R3′, R3″ identically or individually represent H, F, Cl, Br, CF3, CN, NO2, SO2NH2, NHR7, SR8, OR9, CO(OR10), CH2CO(OR11), COR15, a C1-10-alkyl-, aryl-, heteroaryl-aryl radical or a heteroalkyl radical bound by a C1-6 alkylene group, R4=an unsubstituted phenyl radical or a phenyl radical substituted at least with C1-4 alkyl, C1-3-alkoxy-, halogen-, a method for the production of the above-mentioned compounds, medicaments containing said compounds, and the use of said compounds in the production of medicaments. Said active ingredients are particularly suitable for pain therapy, and for treating inflammatory and allergic reactions, drug or alcohol abuse, diarrhoea, gastritis, ulcers, cardiovascular diseases, urinary incontinence, depressions, states of shock, migranes, narcolepsy, overweight, asthma, glaucoma, hyperkinetic syndrome, lack of drive, bulimia, anorexia, catalepsia, anxiolysis increasing vigilance and/or increasing libido.

    Abstract translation: 本发明涉及通式（I）的取代吡咯曼尼希碱，其中R 1 = H，C 1-10烷基 - ，芳基，杂芳基 - 或 由C 1-6亚烷基结合的芳基，杂芳基 - ，CN，Br-，Cl或OH基团，R 2 = CH（R 4） N（R 5）（R 6），R 3，R 3'，R 3'相同或独立地表示H，F，Cl，Br，CF CN，NO 2，SO 2 NH 2，NHR 7，SR 3 CO（OR 10），CH 2 CO（OR 11），或CO 2（OR 10） C 1-4烷基 - ，芳基 - ，杂芳基 - 芳基或被C 1〜C 10结合的杂烷基， 6个亚烷基，R 4 =未取代的苯基或至少被C 1-4烷基取代的苯基，C 1-3 - 烷氧基 - ，卤素 - ，制备上述化合物的方法，含有所述化合物的药物，以及所述化合物在制备中的用途 摄影师 所述活性成分特别适合于疼痛治疗，并且用于治疗炎症和过敏反应，药物或酒精滥用，腹泻，胃炎，溃疡，心血管疾病，尿失禁，沮丧，休克状态，迁移，发作性睡病，超重，哮喘，青光眼 ，运动障碍综合征，缺乏驱动力，贪食症，厌食症，僵硬症，焦虑症增加警惕性和/或增加性欲。

    Bicyclic imidazo-5-yl-amine derivatives
    40.
    发明授权
    Bicyclic imidazo-5-yl-amine derivatives 失效
    双环咪唑-5-基 - 胺衍生物

    公开(公告)号：US06657064B2

    公开(公告)日：2003-12-02

    申请号：US10117335

    申请日：2002-04-08

    Applicant: Matthias Gerlach ,  Corinna Maul

    Inventor： Matthias Gerlach ,  Corinna Maul

    IPC: C07D51304

    CPC classification number: C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07F9/6561 ,  C40B40/00

    Abstract: A novel bicyclic imidazo-5-yl-amine derivative of Formula I, wherein X denotes CR5, N or S, and Y in the case where X denotes S, denotes CR6 or N and in all other cases denotes N, and methods for preparation thereof are disclosed. Also disclosed are methods for treating pain using the compound of Formula I, and pharmaceutical compositions comprising the compound of Formula I.

    Abstract translation: 式I的新型二环咪唑-5-基 - 胺衍生物，其中X表示CR 5，N或S，在X表示S的情况下为Y，表示CR 6或N，在所有其他情况下表示 N及其制备方法。 还公开了使用式I化合物治疗疼痛的方法和包含式I化合物的药物组合物。

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