公开(公告)号：US4757083A

公开(公告)日：1988-07-12

申请号：US936445

申请日：1986-12-01

Applicant: Naoki Higuchi ,  Masayuki Saitoh ,  Masaki Hashimoto ,  Harukazu Fukami ,  Takaharu Tanaka

Inventor： Naoki Higuchi ,  Masayuki Saitoh ,  Masaki Hashimoto ,  Harukazu Fukami ,  Takaharu Tanaka

IPC: A61K31/445 ,  A61K31/40 ,  A61K31/401 ,  A61P25/00 ,  A61P43/00 ,  C07D295/10 ,  C07D295/185 ,  C12N9/99 ,  C07D295/18

CPC classification number: C07D295/185

Abstract: A novel pyrrolidinylamide ester derivative that exhibits inhibitory activity against prolyl endopeptidase, methods for synthesis thereof and its use as an inhibitor against said enzyme are disclosed. The pyrrolidinylamide ester of the invention has the following general formula: ##STR1## wherein n is 0 or an integer of 1 to 7 and R is hydrogen atom or a straight or branched alkyl having 1 to 8 carbon atoms.

Abstract translation: 公开了一种对脯氨酰内肽酶具有抑制活性的新型吡咯烷酰胺酯衍生物，其合成方法及其作为对所述酶的抑制剂的用途。 本发明的吡咯烷酰胺酯具有以下通式：其中n为0或1〜7的整数，R为氢原子或碳原子数为1〜8的直链或支链烷基。

公开(公告)号：US08959834B2

公开(公告)日：2015-02-24

申请号：US13505318

申请日：2010-11-08

Applicant: Masaki Hashimoto

Inventor： Masaki Hashimoto

IPC: A01G31/00 ,  A01G9/02

CPC classification number: A01G9/025 ,  Y02P60/244

Abstract: A plant cultivation container includes a container body having: a plant cultivation space with an opening for planting a plant formed in a front face thereof; and a water reservoir portion for pooling plant cultivation water formed in a lower portion of the plant cultivation space, in which container a water-absorbing plant cultivation flooring material is mounted in the plant cultivation space so that a part of the plant cultivation flooring material is positioned inside the water reservoir portion. One of right and left walls of the container body disposed at right and left ends, respectively, of a front face of the container body is provided with an engaging portion, and the other of the right and left walls is provided with an engaged portion engageable with the engaging portion of another container body, such that a relative angle between two adjacent container bodies is changeable.

Abstract translation: 植物栽培容器包括：容器主体，具有：植物栽培空间，具有用于种植在其前表面上的植物的开口; 以及用于汇集在植物栽培空间的下部形成的植物栽培水的储水部分，其中容器将一种吸水植物栽培地板材料安装在植物栽培空间中，使得植物栽培地板材料的一部分为 定位在储水部分内。 容器主体的右前壁和左侧壁分别位于容器主体前表面的左右两端之一，设有一个接合部分，左右两个壁中的另一个设有可啮合部分 与另一个容器主体的接合部分，使得两个相邻容器主体之间的相对角度是可变的。

公开(公告)号：US20120329846A1

公开(公告)日：2012-12-27

申请号：US13431183

申请日：2012-03-27

Applicant: Hideki Matsumoto ,  Tomohisa Okutsu ,  Tomoko Takeda ,  Hideki Suzuki ,  Tetsuo Yano ,  Masaki Hashimoto ,  Miho Ono ,  Manabu Suzuki

Inventor： Hideki Matsumoto ,  Tomohisa Okutsu ,  Tomoko Takeda ,  Hideki Suzuki ,  Tetsuo Yano ,  Masaki Hashimoto ,  Miho Ono ,  Manabu Suzuki

IPC: A61K31/198 ,  C07D233/64 ,  C07C323/58 ,  C07D209/16 ,  C07C229/24 ,  A61P29/00 ,  C07C229/36 ,  A61K31/4172 ,  A61K31/195 ,  A61K31/405 ,  A61P1/00 ,  C07C229/26 ,  C07C229/08

CPC classification number: A61K31/198 ,  A61K31/405 ,  A61K31/4172 ,  Y02A50/411 ,  A61K2300/00

Abstract: Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-α. A therapeutic or prophylactic agent for inflammatory bowel disease comprising at least one amino acid selected from the group consisting of lysine, histidine, phenylalanine, methionine, tryptophan, glutamine, glycine, cysteine, cystine and threonine, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day; and a TNF-α production inhibitor comprising an amino acid selected from the group consisting of histidine, phenylalanine and tryptophan, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day.

Abstract translation: 公开了用于治疗或预防炎症性肠病的药剂。 还公开了抑制TNF-α产生的药剂。 包含至少一种选自赖氨酸，组氨酸，苯丙氨酸，甲硫氨酸，色氨酸，谷氨酰胺，甘氨酸，半胱氨酸，胱氨酸和苏氨酸的氨基酸的炎症性肠病治疗或预防剂，所述氨基酸以 每日0.1〜4000mg / kg; 和包含选自组氨酸，苯丙氨酸和色氨酸的氨基酸的TNF-α产生抑制剂，所述氨基酸以每天0.1至4000mg / kg的剂量施用。

公开(公告)号：USD651937S1

公开(公告)日：2012-01-10

申请号：US29361150

申请日：2010-05-06

Applicant: Masaki Hashimoto

Designer： Masaki Hashimoto

公开(公告)号：USD650309S1

公开(公告)日：2011-12-13

申请号：US29385115

申请日：2011-02-09

Applicant: Masaki Hashimoto

Designer： Masaki Hashimoto

公开(公告)号：USD644561S1

公开(公告)日：2011-09-06

申请号：US29375831

申请日：2010-09-28

Applicant: Masaki Hashimoto

Designer： Masaki Hashimoto

公开(公告)号：USD644560S1

公开(公告)日：2011-09-06

申请号：US29375822

申请日：2010-09-28

Applicant: Masaki Hashimoto

Designer： Masaki Hashimoto

公开(公告)号：USD644559S1

公开(公告)日：2011-09-06

申请号：US29361895

申请日：2010-05-17

Applicant: Masaki Hashimoto

Designer： Masaki Hashimoto

公开(公告)号：US20090119801A1

公开(公告)日：2009-05-07

申请号：US11902360

申请日：2007-09-20

Applicant: Masaki Hashimoto ,  Takahiro Hayashi

Inventor： Masaki Hashimoto ,  Takahiro Hayashi

IPC: A01N3/02 ,  A01H5/02

CPC classification number: A01N3/00

Abstract: A method for preserving a cut flower involving only an easy and simple procedure, whereby the cut flower can maintain qualities similar to those of the natural state for a long period of time, and a method for manufacturing a processed cut flower that can maintain qualities similar to those of the natural state for a long period of time. The method for preserving a cut flower by replacing the tissue fluid of the cut flower by a preservative solution includes the steps of: (1) a first replacement step in which the tissue fluid of the cut flower is replaced by a hydrophilic organic solvent; and (2) a second replacement step in which the hydrophilic organic solvent having replaced the tissue fluid in the cut flower is replaced by the preservative solution of an organic solvent that has an affinity for the hydrophilic organic solvent and is nonvolatile or hardly-volatile.

Abstract translation: 一种保鲜切花的方法，其仅涉及简单且简单的方法，由此切花能够长时间保持与天然状态相似的品质，以及可以保持品质相似的加工切花的制造方法 对于那些自然状态很长一段时间。 通过用防腐剂溶液代替切花的组织液来保存切花的方法包括以下步骤：（1）第一替换步骤，其中切花的组织液被亲水性有机溶剂代替; 和（2）第二替换步骤，其中将切割的花中的组织液替代的亲水性有机溶剂由对亲水性有机溶剂具有亲和性的有机溶剂的防腐溶液代替，并且是非挥发性的或几乎不挥发的。

公开(公告)号：US20070249717A1

公开(公告)日：2007-10-25

申请号：US11740541

申请日：2007-04-26

Applicant: Tetsuo Yano ,  Masaki Hashimoto ,  Smriga Miroslav ,  Hisayuki Uneyama ,  Kunio Torii

Inventor： Tetsuo Yano ,  Masaki Hashimoto ,  Smriga Miroslav ,  Hisayuki Uneyama ,  Kunio Torii

IPC: A61K31/198

CPC classification number: A61K31/198 ,  A23L33/175

Abstract: The present invention provides an agent for the prophylaxis or treatment of visceral pain associated with gastrointestinal tract diseases, which contains lysine. Using the prophylactic or therapeutic agent, gastrointestinal tract diseases accompanying visceral pain, such as intestinal disorder, irritable bowel syndrome, functional dyspepsia, gastro esophageal disease, functional abdominal pain syndrome, ulcerative colitis and Crohn's disease and the like can be lo treated or prevented. In addition, pharmaceutical agent, food and drink and dietary supplement for the prophylaxis or treatment of visceral pain associated with such gastrointestinal tract diseases are provided. They are highly effective for visceral pain associated with gastrointestinal tract diseases as compared to existing pharmaceutical agents, show reduced side effects, and are highly effective.

Abstract translation: 本发明提供了用于预防或治疗与包含赖氨酸的胃肠道疾病相关的内脏疼痛的药剂。 使用预防或治疗剂，可以治疗或预防伴随内脏痛，诸如肠障，肠易激综合征，功能性消化不良，胃食管疾病，功能性腹痛综合征，溃疡性结肠炎和克罗恩病等的胃肠道疾病。 此外，还提供了用于预防或治疗与这种胃肠道疾病相关的内脏痛的药剂，食物和饮料和膳食补充剂。 与现有的药剂相比，它们与胃肠道疾病相关的内脏痛具有高度的效果，显示出减少的副作用，并且是非常有效的。