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公开(公告)号：US20070249717A1
公开(公告)日：2007-10-25
申请号：US11740541
申请日：2007-04-26
IPC分类号： A61K31/198
CPC分类号： A61K31/198 , A23L33/175
摘要： The present invention provides an agent for the prophylaxis or treatment of visceral pain associated with gastrointestinal tract diseases, which contains lysine. Using the prophylactic or therapeutic agent, gastrointestinal tract diseases accompanying visceral pain, such as intestinal disorder, irritable bowel syndrome, functional dyspepsia, gastro esophageal disease, functional abdominal pain syndrome, ulcerative colitis and Crohn's disease and the like can be lo treated or prevented. In addition, pharmaceutical agent, food and drink and dietary supplement for the prophylaxis or treatment of visceral pain associated with such gastrointestinal tract diseases are provided. They are highly effective for visceral pain associated with gastrointestinal tract diseases as compared to existing pharmaceutical agents, show reduced side effects, and are highly effective.
摘要翻译： 本发明提供了用于预防或治疗与包含赖氨酸的胃肠道疾病相关的内脏疼痛的药剂。 使用预防或治疗剂，可以治疗或预防伴随内脏痛，诸如肠障，肠易激综合征，功能性消化不良，胃食管疾病，功能性腹痛综合征，溃疡性结肠炎和克罗恩病等的胃肠道疾病。 此外，还提供了用于预防或治疗与这种胃肠道疾病相关的内脏痛的药剂，食物和饮料和膳食补充剂。 与现有的药剂相比，它们与胃肠道疾病相关的内脏痛具有高度的效果，显示出减少的副作用，并且是非常有效的。
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2.发明申请公开(公告)号：US20050076398A1
公开(公告)日：2005-04-07
申请号：US10998832
申请日：2004-11-30
申请人： Kazuyoshi Takahashi , Miroslav Smriga , Masaki Hashimoto , Tetsuo Yano , Hisayuki Uneyama , Kunio Torii
发明人： Kazuyoshi Takahashi , Miroslav Smriga , Masaki Hashimoto , Tetsuo Yano , Hisayuki Uneyama , Kunio Torii
CPC分类号： G01N33/5088 , A01K67/02 , A61K49/0008
摘要： The present invention provides animal model of chronic stress diseases produced by feeding lysine deficient diet to the animals and a method for producing the animal model. The effect of medicine on chronic stress diseases can be judged with the animal model. Effective compounds in preventing chronic stress diseases and/or treating patients suffering from chronic stress diseases can be screened by using the animal model.
摘要翻译： 本发明提供通过向动物喂养赖氨酸缺乏饮食而产生的慢性应激疾病的动物模型和用于生产动物模型的方法。 药物对慢性应激疾病的影响可以用动物模型来判断。 可以通过使用动物模型来筛选预防慢性应激疾病和/或治疗患有慢性应激疾病的患者的有效化合物。
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3.发明授权Nutrient composition and composition for prevention/mitigation of digestive tract depression 有权用于预防/减轻消化道抑郁症的营养成分和组成公开(公告)号：US07993668B2
公开(公告)日：2011-08-09
申请号：US11617137
申请日：2006-12-28
申请人： Tatsuro Tanaka , Hisayuki Uneyama , Kunio Torii , Kiyoshi Miwa
发明人： Tatsuro Tanaka , Hisayuki Uneyama , Kunio Torii , Kiyoshi Miwa
IPC分类号： A61K47/00
CPC分类号： A61K31/708 , A23L33/13 , A23L33/175 , A23V2002/00 , A61K9/20 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A23V2200/32 , A23V2250/06
摘要： As a nutritional composition and a composition for the prophylaxis or improvement of lower gastrointestinal function, which improve lower gastrointestinal function and are effective for the prophylaxis or improvement of diarrhea, gastroesophageal reflux or misswallowing caused by administration of a liquid nutritional supplement, the present invention provides a nutritional composition and a composition for the prophylaxis or improvement of lower gastrointestinal function, which comprise at least one kind selected from glutamic acid, 5′-nucleotide and a salt thereof, wherein, when glutamic acid alone is contained, the content thereof on administration is 0.0013-1.3 w/v % as free glutamic acid.
摘要翻译： 作为营养组合物和用于预防或改善较低胃肠功能的组合物，其改善较低的胃肠功能，并且有效预防或改善由施用液体营养补充剂引起的腹泻，胃食管反流或迷失，本发明提供 用于预防或改善下胃肠功能的营养组合物和组合物，其包含选自谷氨酸，5'-核苷酸及其盐中的至少一种，其中，当含有单独的谷氨酸时，其在施用时的含量 为游离谷氨酸为0.0013-1.3w / v％。
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4.发明申请公开(公告)号：US20090291910A1
公开(公告)日：2009-11-26
申请号：US12470924
申请日：2009-05-22
申请人： Hisayuki Uneyama , Tatsuro Tanaka , Kunio Torii , Shinichi Fujita
发明人： Hisayuki Uneyama , Tatsuro Tanaka , Kunio Torii , Shinichi Fujita
IPC分类号： A61K31/70 , A61K31/195
CPC分类号： A61K31/7088 , A23L27/235 , A23L33/13 , A23V2002/00 , A61K31/198 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K2300/00 , A23V2200/32
摘要： The present invention provides an agent and a food for the prophylaxis or improvement of a functional gastrointestinal disorder, which contains, as an active ingredient, at least one kind selected from glutamic acid, 5′-nucleotide and a salt thereof.
摘要翻译： 本发明提供一种用于预防或改善功能性胃肠道疾病的药剂和食品，其含有选自谷氨酸，5'-核苷酸及其盐中的至少一种作为活性成分。
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公开(公告)号：US07186819B2
公开(公告)日：2007-03-06
申请号：US10918857
申请日：2004-12-10
申请人： Ana San Gabriel , Hisayuki Uneyama , Takami Maekawa , Kunio Torii
发明人： Ana San Gabriel , Hisayuki Uneyama , Takami Maekawa , Kunio Torii
IPC分类号： C12N15/12
CPC分类号： C07K14/70571
摘要： The inventive subject matter relates to a glutamate receptor, DNA which encodes the receptor, a transformed cell expressing the receptor, a method for producing the receptor, a method for identifying an agonist, antagonist, or allosteric modulator for glutamic acid, a method for identifying an agonist for glutamic acid, an antibody to the receptor, and processes for making glutamate receptor modulators and pharmaceutical compositions comprising said modulator.
摘要翻译： 本发明涉及谷氨酸受体，编码受体的DNA，表达受体的转化细胞，产生受体的方法，用于鉴定谷氨酸的激动剂，拮抗剂或变构调节剂的方法，鉴定方法 谷氨酸的激动剂，受体的抗体，以及制备谷氨酸受体调节剂的方法和包含所述调节剂的药物组合物。
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6.发明申请Pharmaceutical or Food Composition for Treatment or Prevention of Brain Edema 审中-公开用于治疗或预防脑水肿的药物或食物组合物公开(公告)号：US20070098777A1
公开(公告)日：2007-05-03
申请号：US11562486
申请日：2006-11-22
申请人： Hitoo NISHINO , Kunio Torii , Hisayuki Uneyama
发明人： Hitoo NISHINO , Kunio Torii , Hisayuki Uneyama
IPC分类号： A61K31/405 , A61K9/127
CPC分类号： A61K31/4045 , A23L33/10 , A61K9/127
摘要： Melatonin has an activity of treating or preventing brain edema. Thus, the invention relates to a pharmaceutical composition comprising melatonin as an active ingredient. And, the invention relates to use of melatonin in the preparation of a pharmaceutical composition comprising melatonin as an active ingredient.
摘要翻译： 褪黑激素具有治疗或预防脑水肿的活性。 因此，本发明涉及包含褪黑激素作为活性成分的药物组合物。 而且，本发明涉及褪黑素在制备包含褪黑素作为活性成分的药物组合物中的用途。
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公开(公告)号：US07157250B2
公开(公告)日：2007-01-02
申请号：US10828332
申请日：2004-04-21
申请人： Ana San Gabriel , Takami Maekawa , Hisayuki Uneyama , Kunio Torii
发明人： Ana San Gabriel , Takami Maekawa , Hisayuki Uneyama , Kunio Torii
CPC分类号： C07K14/70571 , A61K38/00 , G01N2500/00
摘要： An agonist or antagonist of glutamic acid or an allosteric modulator is screened by reacting a glutamic acid receptor protein having the following properties with a substance binding thereto in the presence of a test substance and detecting the inhibition or promotion of the reaction:(A) it has a transmembrane domain and an intracellular domain common to those of type 4 metabotropic glutamic acid receptor protein, or(B) it has an extracellular domain by about 316 or 327 amino acid residues shorter than that of the type 4 metabotropic glutamic acid receptor protein.
摘要翻译： 谷氨酸或变构调节剂的激动剂或拮抗剂通过使具有以下特性的谷氨酸受体蛋白质与与其结合的物质在测试物质存在下进行筛选，并检测反应的抑制或促进作用：（A） 具有与4型代谢型谷氨酸受体蛋白质共同的跨膜结构域和细胞内结构域，或（B）其具有比4型代谢型谷氨酸受体蛋白质短约316或327个氨基酸残基的细胞外结构域。
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公开(公告)号：US20060040350A1
公开(公告)日：2006-02-23
申请号：US10922166
申请日：2004-08-20
申请人： Ana San Gabriel , Hisayuki Uneyama , Takami Maekawa , Kunio Torii
发明人： Ana San Gabriel , Hisayuki Uneyama , Takami Maekawa , Kunio Torii
IPC分类号： C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/70571
摘要： The inventive subject matter relates to novel glutamate receptors and utilization thereof; more specifically to a glutamate receptor, DNA which encodes the receptor, a transformed cell expressing the receptor, a method for producing the receptor, a method for identifying an agonist, antagonist, or allosteric modulator for glutamic acid, a method for identifying an agonist for glutamic acid, an antibody to the receptor, and processes for making glutamate receptor modulators and pharmaceutical compositions comprising said modulator.
摘要翻译： 本发明涉及新型谷氨酸受体及其利用; 更具体地涉及谷氨酸受体，编码受体的DNA，表达受体的转化细胞，产生受体的方法，用于鉴定谷氨酸的激动剂，拮抗剂或变构调节剂的方法，鉴定用于谷氨酸的激动剂的方法 谷氨酸，对受体的抗体，以及制备谷氨酸受体调节剂的方法和包含所述调节剂的药物组合物。
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公开(公告)号：US20050282746A1
公开(公告)日：2005-12-22
申请号：US10918857
申请日：2004-12-10
申请人： Ana Gabriel , Hisayuki Uneyama , Takami Maekawa , Kunio Torii
发明人： Ana Gabriel , Hisayuki Uneyama , Takami Maekawa , Kunio Torii
IPC分类号： A61P1/04 , A61P1/12 , A61P1/14 , A61P3/04 , A61P3/10 , A61P43/00 , C07K14/705 , C12N15/12 , A61K38/17 , C07H21/04
CPC分类号： C07K14/70571
摘要： It is intended to disclose a glutamate sensor in taste sensation and digestion and provide techniques using the same. A glutamate-receptor protein having the following characteristics is reacted with a substance binding thereto in the presence of a test substance and thus the inhibition or acceleration of the reaction is detected to thereby search for a glutamate agonist or antagonist or an allosteric modulator: (1) having a transmembrane domain and an intracellular domain common to a type 1 metabolic glutamate receptor protein; and (2) having an extracellular domain shorter by about 409 or 481 amino acid residues than the type 1 metabolic glutamate receptor protein.
摘要翻译： 旨在公开味觉和消化中的谷氨酸盐传感器，并提供使用其的技术。 具有以下特征的谷氨酸受体蛋白质在与测试物质的存在下与结合的物质反应，因此检测到反应的抑制或加速，从而搜索谷氨酸激动剂或拮抗剂或变构调节剂：（1 ）具有跨膜结构域和1型代谢谷氨酸受体蛋白共有的细胞内结构域; 和（2）具有比1型代谢谷氨酸受体蛋白质更短约409或481个氨基酸残基的细胞外结构域。
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公开(公告)号：US20050003481A1
公开(公告)日：2005-01-06
申请号：US10828332
申请日：2004-04-21
申请人： Ana Gabriel , Takami Maekawa , Hisayuki Uneyama , Kunio Torii
发明人： Ana Gabriel , Takami Maekawa , Hisayuki Uneyama , Kunio Torii
CPC分类号： C07K14/70571 , A61K38/00 , G01N2500/00
摘要： An agonist or antagonist of glutamic acid or an allosteric modulator is screened by reacting a glutamic acid receptor protein having the following properties with a substance binding thereto in the presence of a test substance and detecting the inhibition or promotion of the reaction: (A) it has a transmembrane domain and an intracellular domain common to those of type 4 metabotropic glutamic acid receptor protein, or (B) it has an extracellular domain by about 316 or 327 amino acid residues shorter than that of the type 4 metabotropic glutamic acid receptor protein.
摘要翻译： 谷氨酸或变构调节剂的激动剂或拮抗剂通过使具有以下特性的谷氨酸受体蛋白质与与其结合的物质在测试物质存在下进行筛选，并检测反应的抑制或促进作用：（A） 具有与4型代谢型谷氨酸受体蛋白质共同的跨膜结构域和细胞内结构域，或（B）其具有比4型代谢型谷氨酸受体蛋白质短约316或327个氨基酸残基的细胞外结构域。
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