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    PREVENTIVE/THERAPEUTIC AGENT FOR VISCERAL PAIN
    1.
    发明申请
    PREVENTIVE/THERAPEUTIC AGENT FOR VISCERAL PAIN 审中-公开
    用于粘膜疼痛的预防/治疗剂

    公开(公告)号：US20070249717A1

    公开(公告)日：2007-10-25

    申请号：US11740541

    申请日：2007-04-26

    申请人： Tetsuo Yano ,  Masaki Hashimoto ,  Smriga Miroslav ,  Hisayuki Uneyama ,  Kunio Torii

    发明人： Tetsuo Yano ,  Masaki Hashimoto ,  Smriga Miroslav ,  Hisayuki Uneyama ,  Kunio Torii

    IPC分类号： A61K31/198

    CPC分类号： A61K31/198 ,  A23L33/175

    摘要： The present invention provides an agent for the prophylaxis or treatment of visceral pain associated with gastrointestinal tract diseases, which contains lysine. Using the prophylactic or therapeutic agent, gastrointestinal tract diseases accompanying visceral pain, such as intestinal disorder, irritable bowel syndrome, functional dyspepsia, gastro esophageal disease, functional abdominal pain syndrome, ulcerative colitis and Crohn's disease and the like can be lo treated or prevented. In addition, pharmaceutical agent, food and drink and dietary supplement for the prophylaxis or treatment of visceral pain associated with such gastrointestinal tract diseases are provided. They are highly effective for visceral pain associated with gastrointestinal tract diseases as compared to existing pharmaceutical agents, show reduced side effects, and are highly effective.

    摘要翻译： 本发明提供了用于预防或治疗与包含赖氨酸的胃肠道疾病相关的内脏疼痛的药剂。 使用预防或治疗剂，可以治疗或预防伴随内脏痛，诸如肠障，肠易激综合征，功能性消化不良，胃食管疾病，功能性腹痛综合征，溃疡性结肠炎和克罗恩病等的胃肠道疾病。 此外，还提供了用于预防或治疗与这种胃肠道疾病相关的内脏痛的药剂，食物和饮料和膳食补充剂。 与现有的药剂相比，它们与胃肠道疾病相关的内脏痛具有高度的效果，显示出减少的副作用，并且是非常有效的。

    PROMOTER FOR BICARBONATE SECRETION IN GASTROINTESTINAL TRACT
    3.
    发明申请
    PROMOTER FOR BICARBONATE SECRETION IN GASTROINTESTINAL TRACT 审中-公开
    促进剂在胃肠道分泌物中的分离

    公开(公告)号：US20110071075A1

    公开(公告)日：2011-03-24

    申请号：US12888479

    申请日：2010-09-23

    申请人： Koji Takeuchi ,  Eitaro Aihara ,  Eiji Nakamura ,  Tetsuo Yano ,  Mai Hasumura ,  Hisayuki Uneyama

    发明人： Koji Takeuchi ,  Eitaro Aihara ,  Eiji Nakamura ,  Tetsuo Yano ,  Mai Hasumura ,  Hisayuki Uneyama

    IPC分类号： A61K38/00 ,  A61P3/04 ,  A61K31/195 ,  A61K31/135 ,  A61P1/04

    CPC分类号： A61K31/198 ,  A61K31/137 ,  A61K38/05 ,  A61K38/06 ,  A61K45/06 ,  C07K5/0215 ,  C07K5/06043 ,  C07K5/0606 ,  C07K5/06104 ,  C07K5/0819 ,  A61K2300/00

    摘要： A substance is described which can prevent or treat a disease associated with the secretion of an acid. A calcium receptor activator is the active ingredient in a composition which promotes bicarbonate secretion in a gastrointestinal tract. Examples of the calcium receptor activator include γ-Glu-X-Gly, wherein X represents an amino acid or an amino acid derivative, γ-Glu-Val-Y, wherein Y represents an amino acid or an amino acid derivative, γ-Glu-Ala, γ-Glu-Gly, γ-Glu-Cys, γ-Glu-Met, γ-Glu-Thr, γ-Glu-Val, γ-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, γ-Glu-Met(O), γ-Glu-γ-Glu-Val, γ-Glu-Val-NH2, γ-Glu-Val-ol, γ-Glu-Ser, γ-Glu-Tau, γ-Glu-Cys(S-Me)(O), γ-Glu-Leu, γ-Glu-Ile, γ-Glu-t-Leu, and γ-Glu-Cys(S-Me).

    摘要翻译： 描述了可以预防或治疗与分泌酸相关的疾病的物质。 钙受体激活剂是促进胃肠道中碳酸氢盐分泌的组合物中的活性成分。 钙受体活化剂的实例包括γ-Glu-X-Gly，其中X表示氨基酸或氨基酸衍生物，γ-Glu-Val-Y，其中Y表示氨基酸或氨基酸衍生物，γ-Glu -Ala，γ-Glu-Gly，γ-Glu-Cys，γ-Glu-Met，γ-Glu-Thr，γ-Glu-Val，γ-Glu-Orn，Asp-Gly，Cys-Gly，Cys-Met ，Glu-Cys，Gly-Cys，Leu-Asp，γ-Glu-Met（O），γ-Glu-γ-Glu-Val，γ-Glu-Val-NH2，γ-Glu-Val- Glu-Ser，γ-Glu-Tau，γ-Glu-Cys（S-Me）（O），γ-Glu-Leu，γ-Glu-Ile，γ-Glu-t-Leu和γ-Glu-Cys （S-Me）。