公开(公告)号：US07413746B2

公开(公告)日：2008-08-19

申请号：US11803810

申请日：2007-05-15

Applicant: Ni Ding

Inventor： Ni Ding

IPC: A61F

CPC classification number: A61K31/4745 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  B82Y30/00 ,  B82Y40/00 ,  Y10T428/24

Abstract: A coating for a medical device, particularly for a drug eluting stent, is described. The coating includes a self-assembled monolayer.

Abstract translation: 描述了用于医疗装置的涂层，特别是用于药物洗脱支架的涂层。 涂层包括自组装单层。

公开(公告)号：US20070298354A1

公开(公告)日：2007-12-27

申请号：US11820560

申请日：2007-06-19

Applicant: Ni Ding ,  Gene Michal ,  Stephen Pacetti

Inventor： Ni Ding ,  Gene Michal ,  Stephen Pacetti

IPC: G03C5/00 ,  A61F2/06

CPC classification number: A61L31/16 ,  A61L31/084 ,  A61L2300/606

Abstract: A carbon coating on a stent having a bioactive agent covalently attached thereto and methods of making the same are described.

Abstract translation: 描述了具有共价连接于其上的生物活性剂的支架上的碳涂层及其制备方法。

公开(公告)号：US20070218246A1

公开(公告)日：2007-09-20

申请号：US11803810

申请日：2007-05-15

Applicant: Ni Ding

Inventor： Ni Ding

IPC: B32B7/00 ,  B05D1/00

CPC classification number: A61K31/4745 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  B82Y30/00 ,  B82Y40/00 ,  Y10T428/24

Abstract: A coating for a medical device, particularly for a drug eluting stent, is described. The coating includes a self-assembled monolayer.

Abstract translation: 描述了用于医疗装置的涂层，特别是用于药物洗脱支架的涂层。 涂层包括自组装单层。

公开(公告)号：US07232573B1

公开(公告)日：2007-06-19

申请号：US10255911

申请日：2002-09-26

Applicant: Ni Ding

Inventor： Ni Ding

IPC: A61F2/00

CPC classification number: A61K31/4745 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  B82Y30/00 ,  B82Y40/00 ,  Y10T428/24

Abstract: A coating for a medical device, particularly for a drug eluting stent, is described. The coating includes a self-assembled monolayer.

公开(公告)号：US20060198897A1

公开(公告)日：2006-09-07

申请号：US11213288

申请日：2005-08-26

Applicant: Stephen Pacetti ,  Eugene Michal ,  Syed Hossainy ,  Ni Ding ,  Wouter Roorda

Inventor： Stephen Pacetti ,  Eugene Michal ,  Syed Hossainy ,  Ni Ding ,  Wouter Roorda

IPC: A61K9/50 ,  A61K9/16

CPC classification number: A61K31/727 ,  A61K31/728 ,  A61K31/737 ,  A61L31/10 ,  C08L89/00

Abstract: Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.

公开(公告)号：US20060088654A1

公开(公告)日：2006-04-27

申请号：US11296765

申请日：2005-12-06

Applicant: Ni Ding ,  Michael Helmus

Inventor： Ni Ding ,  Michael Helmus

IPC: A61L33/00

CPC classification number: A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61F2210/0014 ,  A61F2250/0067 ,  A61L27/227 ,  A61L31/10 ,  A61L31/141 ,  A61L31/16 ,  A61L33/0011 ,  A61L2300/236 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/606 ,  C08L83/04

Abstract: The present invention is directed to an expandable stent for implantation in a patient comprising a tubular metal body having open ends and a sidewall structure having openings therein and a coating disposed on a surface of said sidewall structure, said coating comprising a hydrophobic biostable elastomeric material and a biologically active material, wherein said coating continuously conforms to said structure in a manner that preserves said openings.

公开(公告)号：US20060018944A1

公开(公告)日：2006-01-26

申请号：US11213290

申请日：2005-08-26

Applicant: Stephen Pacetti ,  Eugene Michal ,  Syed Hossainy ,  Ni Ding ,  Wouter Roorda

Inventor： Stephen Pacetti ,  Eugene Michal ,  Syed Hossainy ,  Ni Ding ,  Wouter Roorda

IPC: A61K31/727 ,  A61F13/00

CPC classification number: A61K31/727 ,  A61K31/728 ,  A61K31/737 ,  A61L31/10 ,  C08L89/00

Abstract: Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.

公开(公告)号：US20050106210A1

公开(公告)日：2005-05-19

申请号：US10989946

申请日：2004-11-16

Applicant: Ni Ding ,  Michael Helmus

Inventor： Ni Ding ,  Michael Helmus

IPC: A61F20060101 ,  A61F2/00 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61K9/00 ,  A61L20060101 ,  A61L27/22 ,  A61L31/00 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L33/00 ,  A61F2/02 ,  A61F2/06 ,  B05D3/00

CPC classification number: A61L31/16 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61F2210/0014 ,  A61F2250/0067 ,  A61L27/227 ,  A61L31/10 ,  A61L31/141 ,  A61L33/0011 ,  A61L2300/222 ,  A61L2300/236 ,  A61L2300/406 ,  A61L2300/42 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2300/622 ,  A61L2420/02 ,  C08L71/02 ,  C08L83/04 ,  C08L83/00 ,  C08L83/08 ,  C08L5/00 ,  C08L75/04

Abstract: A method of coating implantable open lattice metallic stent prosthesis is disclosed which includes sequentially applying a plurality of relatively thin outer layers of a coating composition comprising a solvent mixture of uncured polymeric silicone material and crosslinker and finely divided biologically active species, possibly of controlled average particle size, to form a coating on each stent surface. The coatings are cured in situ and the coated, cured prosthesis are sterilized in a step that includes preferred pretreatment with argon gas plasma and exposure to gamma radiation electron beam, ethylene oxide, steam.

Abstract translation: 公开了一种涂覆可植入的开放格子金属支架假体的方法，其包括依次施加多个相对较薄的涂层组合物的外层，所述涂层组合物包含未固化的聚合物硅氧烷材料和交联剂的溶剂混合物以及细分的生物活性物质，可能是受控的平均颗粒 尺寸，以在每个支架表面上形成涂层。 涂层在原位固化，并且涂覆的固化假体在包括优选的氩气等离子体预处理和暴露于γ射线电子束，环氧乙烷，蒸汽的步骤中被灭菌。

公开(公告)号：US06652581B1

公开(公告)日：2003-11-25

申请号：US09110697

申请日：1998-07-07

Applicant: Ni Ding

Inventor： Ni Ding

IPC: A61F206

CPC classification number: A61F2/82 ,  A61F2/07 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/42

Abstract: The medical devices of the invention have a portion with a porous surface for release of at least one biologically active agent therefrom. The porous surface is made of a material such as a polymer having a plurality of voids. To load the porous surface with a biologically active agent or drug, an electrophoresis method is employed. In this method, a device having a porous surface is placed into a drug solution or suspension, along with an electrode. An electric current is applied to the device and electrode. Under such a current, the drug, which has a positive or negative charge, will be loaded into the pores or voids of the porous surface.

Abstract translation: 本发明的医疗装置具有用于从其释放至少一种生物活性剂的多孔表面的部分。 多孔表面由诸如具有多个空隙的聚合物的材料制成。 为了用生物活性剂或药物加载多孔表面，使用电泳方法。 在该方法中，具有多孔表面的装置与电极一起放入药液或悬浮液中。 电流被施加到器件和电极上。 在这样的电流下，具有正电荷或负电荷的药物将被加载到多孔表面的孔或空隙中。

公开(公告)号：US06620194B2

公开(公告)日：2003-09-16

申请号：US09942716

申请日：2001-08-30

Applicant: Ni Ding ,  Michael N. Helmus

Inventor： Ni Ding ,  Michael N. Helmus

IPC: A61F206

CPC classification number: A61L33/0011 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61F2210/0014 ,  A61F2250/0067 ,  A61L27/227 ,  A61L31/08 ,  A61L31/10 ,  A61L31/141 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/406 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  C08L83/08 ,  C08L71/02 ,  C08L5/00 ,  C08L83/00 ,  C08L83/04

Abstract: A coating and method for a coating an implantable device or prostheses are disclosed. The coating includes an undercoat of polymeric material containing an amount of biologically active material, particularly heparin, dispersed therein. The coating further includes a topcoat which covers less than the entire surface of the undercoat and wherein the topcoat comprises a polymeric material substantially free of pores and porosigens. The polymeric material of the topcoat can be a biostable, biocompatible material which provides long term non-thrombogenicity to the device portion during and after release of the biologically active material.