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31.发明授权2-aminopyridine compounds useful as β-secretase inhibitors for the treatment of alzheimer's disease 有权用作治疗阿尔茨海默病的分泌酶抑制剂的2-氨基吡啶化合物公开(公告)号：US07932275B2
公开(公告)日：2011-04-26
申请号：US11666942
申请日：2005-10-25
IPC分类号： C07D213/73
CPC分类号： C07D213/73
摘要： The present invention is directed to 2-aminopyridine compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
摘要翻译： 本发明涉及作为β-分泌酶的抑制剂并可用于治疗其中涉及β-分泌酶的疾病如阿尔茨海默氏病的2-氨基吡啶化合物。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及β-分泌酶的疾病中的用途。
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32.发明授权Macrocyclic tertiary amine beta-secretase inhibitors for the treatment of alzheimer's disease 有权用于治疗阿尔茨海默病的大环叔胺β-分泌酶抑制剂公开(公告)号：US07678783B2
公开(公告)日：2010-03-16
申请号：US11667913
申请日：2005-11-14
申请人： Philippe G. Nantermet , Hemaka A. Rajapakse , Harold G. Selnick , Stacey Lindsley , Keith P. Moore , Shawn J. Stachel
发明人： Philippe G. Nantermet , Hemaka A. Rajapakse , Harold G. Selnick , Stacey Lindsley , Keith P. Moore , Shawn J. Stachel
IPC分类号： A01N43/00 , A61K31/33 , C07D513/00
CPC分类号： C07D273/01 , C07D267/00 , C07D313/00 , C07D321/00 , C07D323/00 , C07D413/04 , C07D498/08
摘要： The present invention is directed to macrocyclic tertiary amine compounds represented by general formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
摘要翻译： 本发明涉及由通式（I）表示的大环叔胺化合物，其为β-分泌酶的抑制剂，可用于治疗其中涉及β-分泌酶的疾病，例如阿尔茨海默氏病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及β-分泌酶的疾病中的用途。
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33.发明授权Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of Alzheimer's disease 有权苯酰胺和吡啶酰胺β-分泌酶抑制剂治疗阿尔茨海默病公开(公告)号：US07550481B2
公开(公告)日：2009-06-23
申请号：US10582856
申请日：2004-12-15
申请人： James C. Barrow , Craig A. Coburn , Philippe G. Nantermet , Harold G. Selnick , Shawn J. Stachel , Matthew G. Stanton , Shaun R. Stauffer , Linghang Zhuang , Jennifer R. Davis
发明人： James C. Barrow , Craig A. Coburn , Philippe G. Nantermet , Harold G. Selnick , Shawn J. Stachel , Matthew G. Stanton , Shaun R. Stauffer , Linghang Zhuang , Jennifer R. Davis
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07D213/81 , C07D213/75 , C07D257/04 , C07D401/04 , C07D409/12 , C07D413/12
摘要： The present invention is directed to phenylamide and pyridylamide derivative compounds of which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
摘要翻译： 本发明涉及苯酰胺和吡啶酰胺衍生物化合物，其是β-分泌酶的抑制剂，可用于治疗其中涉及β-分泌酶的疾病，例如阿尔茨海默氏病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及β-分泌酶的疾病中的用途。
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34.发明授权Macrocyclic β-secretase inhibitors for the treatment of Alzheimer's disease 有权用于治疗阿尔茨海默氏病的大环β-分泌酶抑制剂公开(公告)号：US07371853B2
公开(公告)日：2008-05-13
申请号：US10541476
申请日：2004-01-02
IPC分类号： C07D267/22 , C07D281/18 , C07D291/00 , C07D337/16 , C07D487/00 , C07D498/00 , C07D513/00
CPC分类号： C07D273/02
摘要： The present invention is directed to compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme in involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the beta-secretase enzyme is involved.
摘要翻译： 本发明涉及作为β-分泌酶的抑制剂并可用于治疗或预防所涉及的β-分泌酶如阿尔茨海默病的疾病的式（I）化合物。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及β-分泌酶的疾病中的用途。
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35.发明授权Phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease 有权苯甲酰胺β-分泌酶抑制剂治疗阿尔茨海默病公开(公告)号：US07348356B2
公开(公告)日：2008-03-25
申请号：US11495123
申请日：2006-07-28
IPC分类号： A61K31/40 , C07D207/06
CPC分类号： C07D207/08 , C07C255/46 , C07C255/57 , C07C311/08 , C07C2601/02 , C07C2601/08 , C07D211/22 , C07D211/32 , C07D211/44 , C07D211/46 , C07D211/74 , C07D491/10
摘要： Disclosed are compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the beta-secretase enzyme is involved.
摘要翻译： 公开了作为β-分泌酶的抑制剂并可用于治疗或预防其中涉及β-分泌酶的疾病（例如阿尔茨海默病）和包含这些化合物的药物组合物的式（I）化合物和 这些化合物和组合物在预防或治疗涉及β-分泌酶的疾病中的应用。
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公开(公告)号：US07109217B2
公开(公告)日：2006-09-19
申请号：US10534291
申请日：2003-11-06
IPC分类号： A01N43/40 , A01N43/36 , C07D211/44 , C07D207/08
CPC分类号： C07D207/08 , C07C255/46 , C07C255/57 , C07C311/08 , C07C2601/02 , C07C2601/08 , C07D211/22 , C07D211/32 , C07D211/44 , C07D211/46 , C07D211/74 , C07D491/10
摘要： Disclosed are compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the beta-secretase enzyme is involved.
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