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    IL-15R ALPHA FORMS, CELLS EXPRESSING IL-15R ALPHA FORMS, AND THERAPEUTIC USES OF IL-15R ALPHA AND IL-15/IL-15R ALPHA COMPLEXES
    32.
    发明申请
    IL-15R ALPHA FORMS, CELLS EXPRESSING IL-15R ALPHA FORMS, AND THERAPEUTIC USES OF IL-15R ALPHA AND IL-15/IL-15R ALPHA COMPLEXES 有权

    公开(公告)号：US20250108092A1

    公开(公告)日：2025-04-03

    申请号：US18672774

    申请日：2024-05-23

    Applicant: Novartis AG ,  The United States of America, as Represented by the Secretary, Department of Health and Human Servic

    Inventor： Barbara K. Felber ,  Sergio Finkielsztein ,  George N. Pavlakis ,  John N. Vournakis

    IPC: A61K38/20 ,  A61K38/17 ,  A61K45/06

    Abstract: In one aspect, described herein are cyclical administration regimens for the administration of complexes comprising interleukin-15 (“IL-15”) covalently or noncovalently bound to IL-15 receptor alpha (“IL-15Ra”) to patients in order to enhance IL-15-mediated immune function. In one aspect, these cyclical administration regimens achieve plasma levels of IL-15 above basal levels while minimizing the toxicity associated with IL-15 administration. In a specific aspect, the cyclical administration regimens are useful in the prevention, treatment, and/or management of disorders in which enhancing IL-15-mediated function is beneficial, such as cancer, infectious diseases, immunodeficiencies and lymphopenia. Also described herein are purified soluble forms of IL-15Ra, cells that recombinantly express soluble forms of IL-15Ra, and compositions comprising complexes of IL-15 covalently or non-covalently bound to soluble forms of IL-15Ra. Further described herein are host cells that recombinantly express IL15-Ra derivatives comprising a mutation or deletion in the extracellular domain cleavage site, including IL-15Ra derivatives comprising the extracellular domain of IL-15Ra and a transmembrane domain of a heterologous molecule. In addition, described herein are methods for propagating, activating and/or differentiating IL-15 responsive cells, comprising co-culturing an IL-15 responsive cell(s) with a host cell(s) that recombinantly expresses IL-15Ra, and isolating the IL-15 responsive cell(s) from the host cell(s). The IL-15 responsive cells that are immune cells can be administered to prevent, treat and/or manage various disorders, including cancer, an infectious disease, an immunodeficiency and lymphopenia. Further, described herein are methods of enhancing IL-15-mediated immune function as well as methods for preventing, treating and/or managing disorders in which enhancing IL-15-mediated function is beneficial, such as cancer, in a subject, the methods comprising administering to the subject a host cell that recombinantly expresses an IL-15Ra described herein.

    Single-pixel imaging through dynamic scattering media
    34.
    发明授权
    Single-pixel imaging through dynamic scattering media 有权

    公开(公告)号：US12260518B2

    公开(公告)日：2025-03-25

    申请号：US17691172

    申请日：2022-03-10

    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy

    Inventor： Mark Bashkansky ,  Samuel Park ,  John F. Reintjes

    IPC: G06T5/00 ,  G06T5/10

    Abstract: A method for using a single-pixel camera to reconstruct images of objects obscured by fog or other dynamic scattering media. A pseudo-random phase or intensity pattern is imposed on illumination beams directed at a target. The beam with the imposed pattern forms a pseudo random pattern on the target. Information regarding the pattern imposed on each pulse is entered into a data processor/controller. The illumination beams with the pseudo random patterns are reflected off the target, collected by receiving optics and a bucket detector and converted into electronic signals fed into the data processor/controller. The data processor/controller applies a high-pass filter to remove slower signal variations produced by dynamic changes in the scattering medium over time. The filtered bucket values are then used together with their corresponding speckle patterns to generate the images using any appropriate reconstruction algorithm such as CGI or CSI.

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