公开(公告)号：US20160237084A1

公开(公告)日：2016-08-18

申请号：US15137502

申请日：2016-04-25

Applicant: AbbVie Inc.

Inventor： Le Wang ,  John Pratt ,  Lisa A. Hasvold ,  Dachun Liu ,  Yujia Dai ,  Steven D. Fidanze ,  James H. Holms ,  Robert A. Mantei ,  Keith F. McDaniel ,  George S. Sheppard ,  William J. McClellan

IPC: C07D471/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, and R5 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).

Abstract translation: 本发明提供式（I）化合物，其中R 1，R 2，R 3，R 4和R 5具有说明书中定义的任何值及其药学上可接受的盐，其可用作治疗疾病和病症的试剂 ，包括炎性疾病，癌症和艾滋病。 还提供了包含一种或多种式（I）化合物的药物组合物。

公开(公告)号：US09309279B2

公开(公告)日：2016-04-12

申请号：US14170199

申请日：2014-01-31

Applicant: AbbVie, Inc. ,  Enanta Pharmaceuticals, Inc.

Inventor： Yiyin Ku ,  Keith F. McDaniel ,  Hui-Ju Chen ,  Jason P. Shanley ,  Dale J. Kempf ,  David J. Grampovnik ,  Ying Sun ,  Dong Liu ,  Yonghua Gai ,  Yat Sun Or ,  Seble H. Wagaw ,  Kenneth Engstrom ,  Tim Grieme ,  Ahmad Sheikh ,  Jianzhang Mei

IPC: C07K1/113 ,  C07D487/04

CPC classification number: C07K1/113 ,  C07D487/04

Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.

公开(公告)号：US20140148573A1

公开(公告)日：2014-05-29

申请号：US14170199

申请日：2014-01-31

Applicant: Enanta Pharmaceuticals, Inc. ,  AbbVie, Inc.

Inventor： Yiyin Ku ,  Keith F. McDaniel ,  Hui-Ju Chen ,  Jason P. Shanley ,  Dale J. Kempf ,  David J. Grampovnik ,  Ying Sun ,  Dong Liu ,  Yonghua Gai ,  Yat Sun Or ,  Seble H. Wagaw ,  Kenneth Engstrom ,  Tim Grieme ,  Ahmad Sheikh ,  Jianzhang Mei

IPC: C07K1/113

CPC classification number: C07K1/113 ,  C07D487/04

Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.