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公开(公告)号：US20140287992A1
公开(公告)日：2014-09-25
申请号：US14299095
申请日：2014-06-09
发明人： Hui-Ju Chen , Keith F. McDaniel , Brian E. Green , Jason P. Shanley , Albert W. Kruger , Jorge Gandarilla , Dennie S. Welch , Russell D. Cink , Steven C. Cullen , Yonghua Gai , Guoqiang Wang , Yat Sun Or
IPC分类号： C07K5/083
CPC分类号： C07K5/081 , C07D487/04
摘要： The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
摘要翻译： 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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公开(公告)号：US09493506B2
公开(公告)日：2016-11-15
申请号：US14299095
申请日：2014-06-09
发明人： Hui-Ju Chen , Keith F. McDaniel , Brian E. Green , Jason P. Shanley , Albert W. Kruger , Jorge Gandarilla , Dennie S. Welch , Russell D. Cink , Steven C. Cullen , Yonghua Gai , Guoqiang Wang , Yat Sun Or
IPC分类号： C07D487/04 , C07K5/083
CPC分类号： C07K5/081 , C07D487/04
摘要： The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
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公开(公告)号：US09309279B2
公开(公告)日：2016-04-12
申请号：US14170199
申请日：2014-01-31
发明人： Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik , Ying Sun , Dong Liu , Yonghua Gai , Yat Sun Or , Seble H. Wagaw , Kenneth Engstrom , Tim Grieme , Ahmad Sheikh , Jianzhang Mei
IPC分类号： C07K1/113 , C07D487/04
CPC分类号： C07K1/113 , C07D487/04
摘要： The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
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公开(公告)号：US20140148573A1
公开(公告)日：2014-05-29
申请号：US14170199
申请日：2014-01-31
发明人： Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik , Ying Sun , Dong Liu , Yonghua Gai , Yat Sun Or , Seble H. Wagaw , Kenneth Engstrom , Tim Grieme , Ahmad Sheikh , Jianzhang Mei
IPC分类号： C07K1/113
CPC分类号： C07K1/113 , C07D487/04
摘要： The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
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公开(公告)号：US20220017511A1
公开(公告)日：2022-01-20
申请号：US17183832
申请日：2021-02-24
申请人： AbbVie Inc.
发明人： Steven D. Fidanze , Lisa A. Hasvold , Dachun Liu , Keith F. McDaniel , John Pratt , Michael Schrimpf , George Sheppard , Le Wang , Bing Li
IPC分类号： C07D471/04
摘要： The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R6, X1, and X2 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).
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公开(公告)号：US09050346B2
公开(公告)日：2015-06-09
申请号：US14203641
申请日：2014-03-11
申请人： AbbVie Inc.
发明人： Lisa A. Hasvold , Dachun Liu , Keith F. McDaniel , John Pratt , George S. Sheppard , Carol K Wada , Kevin R. Woller
IPC分类号： C07D401/02 , C07D401/10 , A61K31/437 , A61K31/4353 , A61K31/5377 , C07D471/04 , A61K31/496 , A61K31/497 , C07D487/04 , A61K31/501 , A61K31/519
CPC分类号： A61K31/5377 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/519 , C07D471/04 , C07D487/04 , Y02A50/463
摘要： The present invention provides for compounds of formula (I) wherein R1, R2, A1, A2, A3, A4, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
摘要翻译： 本发明提供式（I）化合物，其中R1，R2，A1，A2，A3，A4，X和Y具有说明书中定义的任何值及其药学上可接受的盐，其可用作 治疗疾病和病症，包括炎性疾病，癌症和艾滋病。 还提供了包含一种或多种式（I）化合物的药物组合物。
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公开(公告)号：US20210236508A1
公开(公告)日：2021-08-05
申请号：US16996090
申请日：2020-08-18
申请人： AbbVie Inc.
发明人： Le Wang , John K. Pratt , Keith F. McDaniel , Yujia Dai , Steven D. Fidanze , Lisa Hasvold , James H. Holms , Warren M. Kati , Dachun Liu , Robert A. Mantei , William J. McClellan , George S. Sheppard , Carol K. Wada
IPC分类号： A61K31/541 , C07D487/04 , C07D471/04 , A61K31/437 , A61K31/5025 , A61K31/5377 , A61K45/06
摘要： The present invention provides for compounds of formula (I) wherein A1, A2, A3, A4, X1, X2, Y1, L1, G1, Rx, and Ry have any of the values defined thereof in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
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![Substituted 1,4,10-triazadibenzo[cd,f]azulenes, substituted 1,4,5,10-tetraazadibenzo[cd,f]azulenes and substituted 1,4,5,7,10-pentaazadibenzo[cd,f]azulenes as bromodomain inhibitors](/abs-image/US/2018/07/31/US10035800B2/abs.jpg.150x150.jpg)
公开(公告)号：US10035800B2
公开(公告)日：2018-07-31
申请号：US14774866
申请日：2014-03-12
申请人： AbbVie Inc.
发明人： Steven D. Fidanze , Dauchun Liu , Robert A. Mantei , Keith F. McDaniel , John Pratt , George S. Sheppard , Le Wang , Andrew Bogdan , James H. Holms , Justin D. Dietrich , Jasmina Marjanovic , Lisa A. Hasvold , Yujia Dai
IPC分类号： A61K31/437 , C07D471/22 , C07D471/16
CPC分类号： C07D471/22 , A61P13/12 , A61P15/16 , A61P31/18 , A61P35/00 , C07D471/16
摘要： The present invention provides for compounds of formula (I) wherein R1, R2, R6, Y1, Y3, A1, A2, A3 and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
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公开(公告)号：US09493411B2
公开(公告)日：2016-11-15
申请号：US14206061
申请日：2014-03-12
申请人： AbbVie Inc.
发明人： Lisa A. Hasvold , John Pratt , Keith F. McDaniel , George S. Sheppard , Dachun Liu , Steven W. Elmore , Robert D. Hubbard
IPC分类号： C07D207/335 , C07D207/36 , C07D207/34 , C07D401/04 , C07D403/04 , C07D405/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D471/04 , A61K31/496 , A61K31/506 , A61K31/381 , A61K31/341 , A61K31/422 , A61K31/4709 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D401/10 , C07D403/10 , C07D407/12 , C07D409/10 , C07D413/10
CPC分类号： C07D207/34 , C07D207/335 , C07D207/36 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/10 , C07D409/12 , C07D413/10 , C07D413/12 , C07D471/04
摘要： The present invention provides for compounds of formula (I) wherein R1, R2, R3, and R10 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
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公开(公告)号：US20160143916A1
公开(公告)日：2016-05-26
申请号：US15008994
申请日：2016-01-28
申请人： AbbVie Inc.
发明人： Le Wang , John K. Pratt , Keith F. McDaniel , Yujia Dai , Steven D. Fidanze , Lisa Hasvold , James H. Holms , Warren M. Kati , Dachun Liu , Robert A. Mantei , William J. McClellan , George S. Sheppard , Carol K. Wada
IPC分类号： A61K31/541 , A61K45/06 , A61K31/5025 , A61K31/437 , A61K31/5377
CPC分类号： A61K31/541 , A61K31/437 , A61K31/5025 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D487/04
摘要： The present invention provides for compounds of formula (I) wherein A1, A2, A3, A4, X1, X2, Y1, L1, G1, Rx, and Ry have any of the values defined thereof in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
摘要翻译： 本发明提供式（I）化合物，其中A1，A2，A3，A4，X1，X2，Y1，L1，G1，Rx和Ry具有说明书中定义的任何值及其药学上可接受的盐 ，其作为治疗疾病和病症（包括炎性疾病，癌症和AIDS）的药剂是有用的。 还提供了包含一种或多种式（I）化合物的药物组合物。
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