公开(公告)号：US20250101447A1

公开(公告)日：2025-03-27

申请号：US18974011

申请日：2024-12-09

Applicant: Altria Client Services LLC

Inventor： Chengalrayan Kudithipudi ,  Yanxin Shen ,  Dongmei Xu ,  Jesse Frederick ,  Jaemo Yang

IPC: C12N15/82 ,  C07K14/415

Abstract: This disclosure provides a number of sequences involved in axillary bud growth in tobacco, methods of using such sequences, tobacco plants carrying modifications to such sequences or transgenes of such sequences, and tobacco products made from tobacco leaf harvested from such plants.

公开(公告)号：US12163139B2

公开(公告)日：2024-12-10

申请号：US17587441

申请日：2022-01-28

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Jesse Frederick ,  Chengalrayan Kudithipudi ,  Dongmei Xu

IPC: C12N15/82 ,  A24B3/12 ,  A24B15/20 ,  C12N9/88 ,  C12N15/10 ,  C12N15/66 ,  A61K38/00

Abstract: This disclosure provides a number of sequences involved in nitrogen utilization, methods of using such sequences, tobacco plants carrying modifications to such sequences, tobacco plants transgenic for such sequences, and tobacco products made from such plants.

公开(公告)号：US11859192B2

公开(公告)日：2024-01-02

申请号：US17571138

申请日：2022-01-07

Applicant: Altria Client Services LLC

Inventor： Marcos Fernando de Godoy Lusso ,  James A. Strickland ,  Jesse Frederick ,  Dongmei Xu ,  Chengalrayan Kudithipudi

IPC: C12N15/82 ,  A24B13/00

CPC classification number: C12N15/8225 ,  A24B13/00 ,  C12N15/8218 ,  C12N15/8243 ,  C12N15/8261

Abstract: The present disclosure includes methods and compositions for improving leaf quality in low-alkaloid tobacco plants, e.g., by combining inducible promoters and non-coding RNAs for suppression of an ornithine decarboxylase (ODC) gene. Also provided are low alkaloid tobacco plants with normal, suppressed, or otherwise altered polyamine levels. Further provided are tobacco plants with altered total alkaloid, nicotine levels, commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.

公开(公告)号：US11827893B2

公开(公告)日：2023-11-28

申请号：US17067289

申请日：2020-10-09

Applicant: Altria Client Services LLC

Inventor： Sreepriya Pramod ,  Andrew C. Adams ,  Marcos Fernando de Godoy Lusso ,  Gregory A. Davis ,  Jerry W. Morris ,  Dongmei Xu ,  Jesse Frederick

IPC: C12N15/82 ,  A01H6/82

CPC classification number: C12N15/8243

Abstract: The present disclosure relates to tobacco plants, tobacco seeds, compositions, and methods related to the identification and introgression of the Pale Yellow locus in tobacco. It also relates to generating novel mutations within the PY locus in tobacco.

公开(公告)号：US20220267787A1

公开(公告)日：2022-08-25

申请号：US17683227

申请日：2022-02-28

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Chengalrayan Kudiputhi ,  Alec J. Hayes ,  Robert Frank Hart ,  Yanxin Shen ,  Jesse Frederick ,  Dongmei Xu

IPC: C12N15/82 ,  A01H1/04 ,  A01H6/82 ,  A01H1/02 ,  A01H1/06 ,  A01H5/12 ,  A24B13/00 ,  C12Q1/6895

Abstract: Provided herein are genetic markers and a coding sequence associated with a low- or ultra-low anatabine trait in tobacco.

公开(公告)号：US11266174B2

公开(公告)日：2022-03-08

申请号：US15727418

申请日：2017-10-06

Applicant: Altria Client Services LLC

Inventor： Jesse Frederick ,  Chengalrayan Kudithipudi ,  Dongmei Xu

IPC: C12N15/82 ,  A24B3/12 ,  A24B15/20 ,  C12N9/88 ,  C12N15/10 ,  C12N15/66 ,  A61K38/00

Abstract: This disclosure provides a number of sequences involved in nitrogen utilization, methods of using such sequences, tobacco plants carrying modifications to such sequences, tobacco plants transgenic for such sequences, and tobacco products made from such plants.

公开(公告)号：US10813318B2

公开(公告)日：2020-10-27

申请号：US15914033

申请日：2018-03-07

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Jesse Frederick ,  Yanxin Shen ,  Dongmei Xu ,  Ujwala Warek ,  James Arthur Strickland

IPC: A01H5/12 ,  C07K14/415 ,  A01H1/02 ,  A24B15/20 ,  C12N15/82 ,  A01H1/06 ,  C12Q1/6895 ,  G01N33/00

Abstract: This disclosure provides a number of sequences involved in the transport of alkaloids from the root to the leaf in tobacco, methods of using such sequences, tobacco plants carrying modifications to such sequences, and tobacco products made from such plants.

公开(公告)号：US20190069506A1

公开(公告)日：2019-03-07

申请号：US16119366

申请日：2018-08-31

Applicant: Altria Client Services LLC

Inventor： Jesse Frederick ,  Chengalrayan Kudithipudi ,  Dongmei Xu

IPC: A01H6/82 ,  A01H5/10 ,  C12N15/82

Abstract: The present disclosure provides metabolic signatures and genetic markers for tracking enhanced nitrogen utilization efficiency phenotypes in tobacco plants and for introgressing enhanced nitrogen utilization efficiency phenotypes into tobacco plants. The disclosure also provides tobacco plants comprising enhanced nitrogen utilization efficiency and methods to the creation of tobacco plants comprising enhanced nitrogen utilization efficiency. The disclosure also provides recombinant polynucleotides and polypeptides for enhancing nitrogen utilization efficiency in modified tobacco plants and tobacco plants comprising the provided recombinant polynucleotides and polypeptides.

公开(公告)号：US20180199532A1

公开(公告)日：2018-07-19

申请号：US15914033

申请日：2018-03-07

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Jesse Frederick ,  Yanxin Shen ,  Dongmei Xu ,  Ujwala Warek ,  James Arthur Strickland

IPC: A01H5/12 ,  G01N33/00 ,  A01H1/02 ,  A01H1/06 ,  A24B15/20 ,  C12Q1/6895 ,  C12N15/82 ,  C07K14/415

Abstract: This disclosure provides a number of sequences involved in the transport of alkaloids from the root to the leaf in tobacco, methods of using such sequences, tobacco plants carrying modifications to such sequences, and tobacco products made from such plants.