公开(公告)号：US12270037B2

公开(公告)日：2025-04-08

申请号：US17766786

申请日：2020-10-09

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Chengalrayan Kudithipudi ,  Rajanikanth Govindarajulu ,  Nazmul Bhuiyan ,  Raja Payyavula ,  Yanxin Shen ,  Dongmei Xu

IPC: C12N15/82 ,  C07K14/415 ,  C12N15/113

Abstract: The present disclosure provides composition and methods for improving leaf quality of low-alkaloid tobacco plants. Also provided are the identification and genetic engineering of target genes (Leaf Quality Genes) for producing tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.

公开(公告)号：US11999961B2

公开(公告)日：2024-06-04

申请号：US17830072

申请日：2022-06-01

Applicant: Altria Client Services LLC

Inventor： Chengalrayan Kudithipudi ,  Dongmei Xu ,  James Strickland ,  Yanxin Shen

IPC: C12N15/82 ,  A01H6/82 ,  A24B13/00 ,  A24B15/10 ,  A24B15/24

CPC classification number: C12N15/8243 ,  A01H6/823 ,  A24B13/00 ,  A24B15/10 ,  A24B15/245 ,  C12N15/8251 ,  C12Y402/01091

Abstract: The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radicle absorbance capacity (ORAC), increase phenylalanine, or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.

公开(公告)号：US11873500B2

公开(公告)日：2024-01-16

申请号：US17683227

申请日：2022-02-28

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Chengalrayan Kudithipudi ,  Alec J. Hayes ,  Robert Frank Hart ,  Yanxin Shen ,  Jesse Frederick ,  Dongmei Xu

IPC: A01H6/82 ,  A01H5/12 ,  A01H1/06 ,  A24B13/00 ,  C12N15/82 ,  A01H1/04 ,  C12Q1/6895

CPC classification number: C12N15/8261 ,  A01H1/045 ,  A01H1/06 ,  A01H5/12 ,  A01H6/823 ,  A24B13/00 ,  C12N15/8218 ,  C12N15/8243 ,  C12Q1/6895 ,  C12Q2600/13 ,  C12Q2600/156

Abstract: Provided herein are genetic markers and a coding sequence associated with a low- or ultra-low anatabine trait in tobacco.

公开(公告)号：US11845946B2

公开(公告)日：2023-12-19

申请号：US17518303

申请日：2021-11-03

Applicant: Altria Client Services LLC

Inventor： Yanxin Shen ,  Dongmei Xu

IPC: C12N15/82 ,  C07K14/415 ,  C12N9/02 ,  A01H1/06 ,  A01H5/12 ,  A24B13/00

CPC classification number: C12N15/8261 ,  A01H1/06 ,  A01H5/12 ,  A24B13/00 ,  C07K14/415 ,  C12N9/0073 ,  C12N15/825 ,  C12N15/8218 ,  C12N15/8251 ,  C12N15/8269 ,  C12Y114/13122 ,  Y02A40/146

Abstract: This disclosure provides tobacco plants that exhibit altered photosynthesis as well as methods of making and using such plants.

公开(公告)号：US11452275B2

公开(公告)日：2022-09-27

申请号：US17005942

申请日：2020-08-28

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Jesse Frederick ,  Yanxin Shen ,  Dongmei Xu ,  Ujwala Warek ,  James Arthur Strickland

IPC: A01H5/12 ,  A24B15/20 ,  C12N15/82 ,  A01H6/82 ,  C07K14/415 ,  A01H1/02 ,  A01H1/06 ,  C12Q1/6895 ,  G01N33/00

Abstract: This disclosure provides a number of sequences involved in the transport of alkaloids from the root to the leaf in tobacco, methods of using such sequences, tobacco plants carrying modifications to such sequences, and tobacco products made from such plants.

公开(公告)号：US20220267785A1

公开(公告)日：2022-08-25

申请号：US17684078

申请日：2022-03-01

Applicant: Altria Client Services LLC

Inventor： Chengalrayan KUDITHIPUDI ,  Jaemo Yang ,  Yanxin Shen ,  Dongmei Xu ,  Ujwala Warek ,  James Strickland ,  Jesse Frederick

IPC: C12N15/82

Abstract: The present disclosure provides the identification of promoters that are preferentially active in tobacco axillary buds. Also provided are tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing tobacco plants comprising reduced or no sucker growth.

公开(公告)号：US11174490B2

公开(公告)日：2021-11-16

申请号：US16579271

申请日：2019-09-23

Applicant: Altria Client Services LLC

Inventor： Yanxin Shen ,  Dongmei Xu

IPC: C12N15/82 ,  C07K14/415 ,  C12N9/02 ,  A01H1/06 ,  A01H5/12 ,  A24B13/00

Abstract: This disclosure provides tobacco plants that exhibit altered photosynthesis as well as methods of making and using such plants.

公开(公告)号：US11034969B2

公开(公告)日：2021-06-15

申请号：US16228035

申请日：2018-12-20

Applicant: Altria Client Services LLC

Inventor： Chengalrayan Kudithipudi ,  Raja Payyavula ,  Dong Qi ,  Yanxin Shen

IPC: C12N15/82 ,  C07K14/415

Abstract: The present specification provides for, and includes recombinant polynucleotides that encode plant-native, callus-preferred promoters operably linked to a coding region for a visual marker gene. The present specification also provides for, and includes plants comprising the recombinant nucleotides, methods to select callus comprising the disclosed recombinant nucleotides, and methods to create plants comprising the recombinant nucleotides.

公开(公告)号：US20200010845A1

公开(公告)日：2020-01-09

申请号：US16579271

申请日：2019-09-23

Applicant: Altria Client Services LLC

Inventor： Yanxin Shen ,  Dongmei Xu

IPC: C12N15/82 ,  A24B13/00

Abstract: This disclosure provides tobacco plants that exhibit altered photosynthesis as well as methods of making and using such plants.

公开(公告)号：US20250101447A1

公开(公告)日：2025-03-27

申请号：US18974011

申请日：2024-12-09

Applicant: Altria Client Services LLC

Inventor： Chengalrayan Kudithipudi ,  Yanxin Shen ,  Dongmei Xu ,  Jesse Frederick ,  Jaemo Yang

IPC: C12N15/82 ,  C07K14/415

Abstract: This disclosure provides a number of sequences involved in axillary bud growth in tobacco, methods of using such sequences, tobacco plants carrying modifications to such sequences or transgenes of such sequences, and tobacco products made from tobacco leaf harvested from such plants.