公开(公告)号：US12284977B2

公开(公告)日：2025-04-29

申请号：US18163499

申请日：2023-02-02

Applicant: Altria Client Services LLC

Inventor： Jesse Frederick ,  Chengalrayan Kudithipudi ,  Dongmei Xu

IPC: A01H6/82 ,  A01H5/10 ,  A01H5/12 ,  C07K14/415 ,  C12N9/10 ,  C12N9/88 ,  C12N9/90 ,  C12N15/82

Abstract: The present disclosure provides metabolic signatures and genetic markers for tracking enhanced nitrogen utilization efficiency phenotypes in tobacco plants and for introgressing enhanced nitrogen utilization efficiency phenotypes into tobacco plants. The disclosure also provides tobacco plants comprising enhanced nitrogen utilization efficiency and methods to the creation of tobacco plants comprising enhanced nitrogen utilization efficiency. The disclosure also provides recombinant polynucleotides and polypeptides for enhancing nitrogen utilization efficiency in modified tobacco plants and tobacco plants comprising the provided recombinant polynucleotides and polypeptides.

公开(公告)号：US20250064011A1

公开(公告)日：2025-02-27

申请号：US18943128

申请日：2024-11-11

Applicant: Altria Client Services LLC

Inventor： Jesse Frederick ,  Yanxin Shen ,  Dongmei Xu ,  Ujwala Warek ,  James Arthur Strickland

IPC: A01H6/82 ,  A01H1/02 ,  A01H1/06 ,  A01H5/12 ,  A24B15/20 ,  C07K14/415 ,  C12N15/82 ,  C12Q1/6895 ,  G01N33/00

Abstract: This disclosure provides a number of sequences involved in the transport of alkaloids from the root to the leaf in tobacco, methods of using such sequences, tobacco plants carrying modifications to such sequences, and tobacco products made from such plants.

公开(公告)号：US12075746B2

公开(公告)日：2024-09-03

申请号：US16246281

申请日：2019-01-11

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Sreepriya Pramod ,  Marcos Fernando de Godoy Lusso ,  Jesse Frederick ,  Andrew Carl Adams ,  Dongmei Xu

IPC: A01H1/06 ,  A01H6/82 ,  A24B3/08 ,  A24B3/12 ,  A24B13/00 ,  A24B15/10 ,  A24B15/20 ,  A24B15/24 ,  C12N15/82

CPC classification number: A01H6/823 ,  A01H1/06 ,  A24B3/08 ,  A24B3/12 ,  A24B13/00 ,  A24B15/10 ,  A24B15/20 ,  A24B15/243 ,  C12N15/8218 ,  C12N15/8227

Abstract: The present disclosure provides tobacco Nic1b locus and associated genes. Also provided are tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants. Further provided are compositions and methods for producing tobacco plants having novel mutations or alleles to reduce nicotine levels. Further provided are sequence polymorphisms and molecular markers for breeding tobacco with reduced nicotine or alkaloids while maintaining tobacco leaf grade and tobacco product quality.

公开(公告)号：US11950563B2

公开(公告)日：2024-04-09

申请号：US16246308

申请日：2019-01-11

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Sreepriya Pramod ,  Marcos Fernando de Godoy Lusso ,  Jesse Frederick ,  Andrew Carl Adams ,  Dongmei Xu

IPC: C12N15/82 ,  A01H1/06 ,  A01H6/82 ,  A24B3/08 ,  A24B3/12 ,  A24B13/00 ,  A24B15/10 ,  A24B15/20 ,  A24B15/24

CPC classification number: A01H6/823 ,  A01H1/06 ,  A24B3/08 ,  A24B3/12 ,  A24B13/00 ,  A24B15/10 ,  A24B15/20 ,  A24B15/243 ,  C12N15/8218 ,  C12N15/8227

Abstract: The present disclosure provides tobacco Nic1b locus and associated genes (e.g., a group of ERF genes). Also provided are tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants. Further provided are compositions and methods for producing tobacco plants having novel mutations or alleles to reduce nicotine levels. Further provided are sequence polymorphisms and molecular markers for breeding tobacco with reduced nicotine or alkaloids while maintaining tobacco leaf grade and tobacco product quality.

公开(公告)号：US11879130B2

公开(公告)日：2024-01-23

申请号：US17406829

申请日：2021-08-19

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Dongmei Xu ,  Jesse Frederick ,  Chengalrayan Kudithipudi ,  Yanxin Shen ,  James Strickland ,  Jaemo Yang

IPC: C12N15/82 ,  C07K14/415

CPC classification number: C12N15/8265 ,  C07K14/415 ,  C12N15/8213 ,  C12N15/8218 ,  C12N15/8225 ,  C12N15/8229 ,  C12N15/8261 ,  C12N15/8262 ,  C12N15/8294 ,  C12N2310/20

Abstract: The present disclosure provides the identification of genes involved in sucker growth in tobacco. Also provided are promoters that are preferentially active in tobacco axillary buds. Also provided are modified tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing modified tobacco plants comprising reduced or no sucker growth.

公开(公告)号：US11104912B2

公开(公告)日：2021-08-31

申请号：US16124941

申请日：2018-09-07

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Dongmei Xu ,  Jesse Frederick ,  Chengalrayan Kudithipudi ,  Yanxin Shen ,  James Strickland ,  Jaemo Yang

IPC: C12N15/82 ,  C07K14/415

Abstract: The present disclosure provides the identification of genes involved in sucker growth in tobacco. Also provided are promoters that are preferentially active in tobacco axillary buds. Also provided are modified tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing modified tobacco plants comprising reduced or no sucker growth.

公开(公告)号：US12234469B2

公开(公告)日：2025-02-25

申请号：US17337161

申请日：2021-06-02

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Sreepriya Pramod ,  Marcos Fernando de Godoy Lusso ,  Jesse Frederick ,  Andrew Adams ,  Dongmei Xu

IPC: C12N15/82

Abstract: The present disclosure provides tobacco having genetic modification(s) in a group of ERF genes. Also provided are tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants. Further provided are compositions and methods for producing tobacco plants having novel mutations or alleles to reduce nicotine levels. Further provided are sequence polymorphisms and molecular markers for breeding tobacco with reduced nicotine or alkaloids while maintaining tobacco leaf grade and tobacco product quality.

公开(公告)号：US20250051794A1

公开(公告)日：2025-02-13

申请号：US18928836

申请日：2024-10-28

Applicant: Altria Client Services LLC

Inventor： Jesse Frederick ,  Chengalrayan Kudithipudi ,  Dongmei Xu

IPC: C12N15/82 ,  A24B3/12 ,  A24B15/20 ,  A61K38/00 ,  C12N9/88 ,  C12N15/10 ,  C12N15/66

Abstract: This disclosure provides a number of sequences involved in nitrogen utilization, methods of using such sequences, tobacco plants carrying modifications to such sequences, tobacco plants transgenic for such sequences, and tobacco products made from such plants.

公开(公告)号：US11873500B2

公开(公告)日：2024-01-16

申请号：US17683227

申请日：2022-02-28

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Chengalrayan Kudithipudi ,  Alec J. Hayes ,  Robert Frank Hart ,  Yanxin Shen ,  Jesse Frederick ,  Dongmei Xu

IPC: A01H6/82 ,  A01H5/12 ,  A01H1/06 ,  A24B13/00 ,  C12N15/82 ,  A01H1/04 ,  C12Q1/6895

CPC classification number: C12N15/8261 ,  A01H1/045 ,  A01H1/06 ,  A01H5/12 ,  A01H6/823 ,  A24B13/00 ,  C12N15/8218 ,  C12N15/8243 ,  C12Q1/6895 ,  C12Q2600/13 ,  C12Q2600/156

Abstract: Provided herein are genetic markers and a coding sequence associated with a low- or ultra-low anatabine trait in tobacco.

公开(公告)号：US11452275B2

公开(公告)日：2022-09-27

申请号：US17005942

申请日：2020-08-28

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Jesse Frederick ,  Yanxin Shen ,  Dongmei Xu ,  Ujwala Warek ,  James Arthur Strickland

IPC: A01H5/12 ,  A24B15/20 ,  C12N15/82 ,  A01H6/82 ,  C07K14/415 ,  A01H1/02 ,  A01H1/06 ,  C12Q1/6895 ,  G01N33/00

Abstract: This disclosure provides a number of sequences involved in the transport of alkaloids from the root to the leaf in tobacco, methods of using such sequences, tobacco plants carrying modifications to such sequences, and tobacco products made from such plants.