公开(公告)号：US12203082B2

公开(公告)日：2025-01-21

申请号：US17551565

申请日：2021-12-15

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Chengalrayan Kudithipudi ,  Yanxin Shen ,  Dongmei Xu ,  Jesse Frederick ,  Jaemo Yang

IPC: C12N15/82 ,  C07K14/415

Abstract: This disclosure provides a number of sequences involved in axillary bud growth in tobacco, methods of using such sequences, tobacco plants carrying modifications to such sequences or transgenes of such sequences, and tobacco products made from tobacco leaf harvested from such plants.

公开(公告)号：US20240099257A1

公开(公告)日：2024-03-28

申请号：US18163499

申请日：2023-02-02

Applicant: Altria Client Services LLC

Inventor： Jesse Frederick ,  Chengalrayan Kudithipudi ,  Dongmei Xu

IPC: A01H6/82 ,  A01H5/10 ,  A01H5/12 ,  C07K14/415 ,  C12N9/10 ,  C12N9/88 ,  C12N9/90 ,  C12N15/82

CPC classification number: A01H6/823 ,  A01H5/10 ,  A01H5/12 ,  C07K14/415 ,  C12N9/1085 ,  C12N9/88 ,  C12N9/90 ,  C12N15/8227 ,  C12N15/8237 ,  C12N15/8261 ,  C12Y205/01054 ,  C12Y402/01033 ,  C12Y501/03015

Abstract: The present disclosure provides metabolic signatures and genetic markers for tracking enhanced nitrogen utilization efficiency phenotypes in tobacco plants and for introgressing enhanced nitrogen utilization efficiency phenotypes into tobacco plants. The disclosure also provides tobacco plants comprising enhanced nitrogen utilization efficiency and methods to the creation of tobacco plants comprising enhanced nitrogen utilization efficiency. The disclosure also provides recombinant polynucleotides and polypeptides for enhancing nitrogen utilization efficiency in modified tobacco plants and tobacco plants comprising the provided recombinant polynucleotides and polypeptides.

公开(公告)号：US11807860B2

公开(公告)日：2023-11-07

申请号：US16908891

申请日：2020-06-23

Applicant: Altria Client Services LLC

Inventor： Dongmei Xu ,  Chengalrayan Kudithipudi ,  Yanxin Shen ,  Jaemo Yang ,  Jesse Frederick ,  James Strickland

IPC: C12N15/82 ,  C07K14/415 ,  A24B13/00 ,  A24B15/10

CPC classification number: C12N15/8261 ,  A24B13/00 ,  A24B15/10 ,  C07K14/415 ,  C12N15/827 ,  Y02A40/146

Abstract: The present disclosure provides the identification of genes involved in sucker growth in tobacco. Also provided are promoters that are preferentially active in tobacco axillary buds. Also provided are modified tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing modified tobacco plants comprising reduced or no sucker growth.

公开(公告)号：US11767535B2

公开(公告)日：2023-09-26

申请号：US17684078

申请日：2022-03-01

Applicant: Altria Client Services LLC

Inventor： Chengalrayan Kudithipudi ,  Jaemo Yang ,  Yanxin Shen ,  Dongmei Xu ,  Ujwala Warek ,  James Strickland ,  Jesse Frederick

IPC: C12N15/82

CPC classification number: C12N15/8235 ,  C12N15/827

Abstract: The present disclosure provides the identification of promoters that are preferentially active in tobacco axillary buds. Also provided are tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing tobacco plants comprising reduced or no sucker growth.

公开(公告)号：US11299743B2

公开(公告)日：2022-04-12

申请号：US16825394

申请日：2020-03-20

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Chengalrayan Kudithipudi ,  Alec J. Hayes ,  Robert Frank Hart, III ,  Yanxin Shen ,  Jesse Frederick ,  Dongmei Xu

IPC: C12N15/82 ,  A24B13/00 ,  A01H1/04 ,  A01H6/82 ,  A01H1/02 ,  A01H1/06 ,  A01H5/12 ,  C12Q1/6895

Abstract: Provided herein are genetic markers and a coding sequence associated with a low- or ultra-low anatabine trait in tobacco.

公开(公告)号：US11236349B2

公开(公告)日：2022-02-01

申请号：US16589783

申请日：2019-10-01

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Chengalrayan Kudithipudi ,  Yanxin Shen ,  Dongmei Xu ,  Jesse Frederick ,  Jaemo Yang

IPC: C12N15/82 ,  C07K14/415

Abstract: This disclosure provides a number of sequences involved in axillary bud growth in tobacco, methods of using such sequences, tobacco plants carrying modifications to such sequences or transgenes of such sequences, and tobacco products made from tobacco leaf harvested from such plants.

公开(公告)号：US11220695B2

公开(公告)日：2022-01-11

申请号：US16291878

申请日：2019-03-04

Applicant: Altria Client Services LLC

Inventor： Marcos Fernando de Godoy Lusso ,  James A Strickland ,  Jesse Frederick ,  Dongmei Xu ,  Chengalrayan Kudithipudi

IPC: C12N15/82 ,  A24B13/00

Abstract: The present disclosure includes methods and compositions for improving leaf quality in low-alkaloid tobacco plants, e.g., by combining inducible promoters and non-coding RNAs for suppression of an ornithine decarboxylase (ODC) gene. Also provided are low alkaloid tobacco plants with normal, suppressed, or otherwise altered polyamine levels. Further provided are tobacco plants with altered total alkaloid, nicotine levels, commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.

公开(公告)号：US20200040350A1

公开(公告)日：2020-02-06

申请号：US16529365

申请日：2019-08-01

Applicant: Altria Client Services LLC

Inventor： Chengalrayan Kudithipudi ,  Jaemo Yang ,  Yanxin Shen ,  Dongmei Xu ,  Ujwala Warek ,  James Strickland ,  Jesse Frederick

IPC: C12N15/82

Abstract: The present disclosure provides the identification of promoters that are preferentially active in tobacco axillary buds. Also provided are tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing tobacco plants comprising reduced or no sucker growth.

公开(公告)号：US20190300893A1

公开(公告)日：2019-10-03

申请号：US16372833

申请日：2019-04-02

Applicant: Altria Client Services LLC

Inventor： Chengalrayan Kudithipudi ,  Dongmei Xu ,  James Strickland ,  Yanxin Shen

IPC: C12N15/82 ,  A24B15/10

Abstract: The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radical absorbance capacity (ORAC), increase phenylalanine, or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.

公开(公告)号：US20190281883A1

公开(公告)日：2019-09-19

申请号：US16427741

申请日：2019-05-31

Applicant: Altria Client Services LLC

Inventor： John KOTROLA ,  Ujwala Warek ,  James Arthur Strickland ,  Elisabeth Miller ,  Dongmei Xu

IPC: A24B15/12 ,  A24B3/14 ,  A24B15/28

Abstract: Methods of making reconstituted tobacco include contacting a mixture including tobacco pulp with one or more fluid streams including one or more peroxides (e.g., hydrogen peroxide), recovering one or more fluids from the tobacco pulp mixture, and reusing the recovered fluids in at least one subsequent tobacco pulp contacting step. In some cases, methods provided herein can recover one or more fluids including one or more peroxides, such that the at least one subsequent tobacco pulp contacting step includes contacting tobacco pulp with a fluid including one or more peroxides.