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公开(公告)号：US06531040B2
公开(公告)日：2003-03-11
申请号：US09731943
申请日：2000-12-08
IPC分类号： G01N2726
CPC分类号： C12Q1/001 , G01N27/3274
摘要： Disclosed is an electrochemical sensor for detecting the concentration of an analyte such as glucose in a fluid test sample. The sensor involves a base as flow path for the fluid test sample having a working and counter electrode on its surface. The base is mated with a cover to form a capillary space to capture the fluid and the counter electrode has a sub-element located upstream in the flow path. When there is detected electrical communication only between the sub-element and the working electrode the meter, with which the sensor is in electrical communication senses that the capillary space has not completely filled with test fluid.
摘要翻译： 公开了一种用于检测流体测试样品中诸如葡萄糖的分析物浓度的电化学传感器。 该传感器涉及一个流动测试样品的流动路径，其底部具有在其表面上的工作和反电极。 基座与盖子配合以形成毛细管空间以捕获流体，并且对电极具有位于流动路径上游的子元件。 当仅在子元件和工作电极之间检测到电气通信时，与传感器电连通的仪表可以检测到毛细管空间未完全充满测试流体。
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公开(公告)号：US08940153B2
公开(公告)日：2015-01-27
申请号：US12083952
申请日：2006-11-13
摘要： A test sensor reagent for measuring the concentration of analytes in body fluids includes cellulose polymers for improving the stability of the test sensor and reducing the total assay time. The test sensor reagent also includes an enzyme, an electron transfer mediator and a rheological additive.
摘要翻译： 用于测量体液中分析物浓度的测试传感器试剂包括用于改善测试传感器的稳定性并减少总测定时间的纤维素聚合物。 测试传感器试剂还包括酶，电子转移介体和流变添加剂。
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公开(公告)号：US07939019B2
公开(公告)日：2011-05-10
申请号：US11920301
申请日：2006-05-22
申请人： Andrew J. Edelbrock
发明人： Andrew J. Edelbrock
IPC分类号： G01N21/00
CPC分类号： G01N33/48771 , Y10T436/2575
摘要： An interim auto-calibration circuit or label adapted to be used with a sensor package. The sensor package is adapted to be used with first and second instruments to determine the analyte concentration of fluid sample. The instruments are different and include respective first and second plurality of pins that are in different patterns. The sensor package comprises a plurality of electrical connections that includes a plurality of contact areas. The contact areas have a first and second contact sections being shorted together. The first contact sections are adapted to contact a respective one of the first pins. The second contact sections are adapted to contact a respective one of the second pins. The electrical connections assist in conveying information corresponding to the test sensors. The information is adapted to be utilized by the first and the second instruments to auto-calibrate for the test sensors.
摘要翻译： 适用于传感器封装的临时自动校准电路或标签。 传感器组件适用于与第一和第二仪器一起使用以确定流体样品的分析物浓度。 仪器是不同的，并且包括处于不同图案的相应的第一和第二多个销。 传感器封装包括多个电连接，其包括多个接触区域。 接触区域具有短接在一起的第一和第二接触部分。 第一接触部分适于接触第一引脚中的相应一个。 第二接触部分适于接触相应的一个第二引脚。 电气连接有助于传送与测试传感器相对应的信息。 该信息适于由第一和第二仪器利用以自动校准测试传感器。
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34.发明申请Method of Defining Electrodes Using Laser-Ablation and Dielectric Material 审中-公开使用激光烧蚀和电介质材料定义电极的方法公开(公告)号：US20100227080A1
公开(公告)日：2010-09-09
申请号：US12679059
申请日：2008-10-02
申请人： Greg P. Beer , Andrew J. Edelbrock
发明人： Greg P. Beer , Andrew J. Edelbrock
IPC分类号： B05D3/06
CPC分类号： G01N27/3272
摘要： A method of forming an electrochemical test sensor includes providing a base. Electrochemically-active material is placed on the base. Dielectric material is applied over the electrochemically-active material. A first selected area of the dielectric material is laser-ablated to expose the electrochemically-active material. A second selected area of the dielectric material and the electrochemically-active material are laser-ablated to expose the base. The first selected area is different from the second selected area. A second layer is applied to assist in forming a channel in the test sensor. The channel assists in allowing a fluid sample to contact a reagent located therein. The dielectric material is located between the base and the second layer.
摘要翻译： 形成电化学测试传感器的方法包括提供基底。 将电化学活性材料放置在基底上。 介电材料涂覆在电化学活性材料上。 电介质材料的第一选择区域被激光烧蚀以暴露电化学活性材料。 电介质材料和电化学活性材料的第二选择区域被激光烧蚀以露出基底。 第一选区与第二选区不同。 施加第二层以辅助在测试传感器中形成通道。 该通道有助于允许流体样品与位于其中的试剂接触。 介电材料位于基底和第二层之间。
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公开(公告)号：US20090159197A1
公开(公告)日：2009-06-25
申请号：US12086240
申请日：2006-12-21
申请人： Andrew J. Edelbrock
发明人： Andrew J. Edelbrock
CPC分类号： C12Q1/001 , B23K26/38 , B23K2101/18 , B23K2101/20 , G01N27/3272 , Y10T156/1052 , Y10T156/1056 , Y10T156/1057 , Y10T156/1062 , Y10T156/1064
摘要： A method of forming an electrochemical multilayer test sensor that includes a base, a second layer and a reactive layer. The reactive area includes an enzyme. The test sensor is adapted to be used in a meter and assist in determining the concentration of an analyte. A plurality of electrodes and their respective conductive leads are partially defined on the base. After partially defining the plurality of electrodes and their respective conductive leads on the base, the base is attached to a second layer to define a reaction zone in which the plurality of electrodes are fully defined. After attaching the base to the second layer, the plurality of conductive leads on the base of the test sensor are fully defined.
摘要翻译： 一种形成电化学多层测试传感器的方法，其包括基底，第二层和反应层。 反应性区域包括酶。 测试传感器适用于仪表，有助于确定分析物的浓度。 多个电极及其各自的导电引线部分地限定在基座上。 在基底部分地限定多个电极及其各自的导电引线之后，将基座附接到第二层以限定其中多个电极被完全限定在其中的反应区域。 在将基座安装到第二层之后，在测试传感器的底部上的多个导电引线被完全限定。
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公开(公告)号：US07118668B1
公开(公告)日：2006-10-10
申请号：US10978889
申请日：2004-11-01
IPC分类号： G01N27/327 , G01N27/333
CPC分类号： C12Q1/004 , A61M2230/201 , C12Q1/001 , G01N27/3274
摘要： Disclosed is an electrochemical sensor for the determination of analytes in body fluids, e.g. glucose in blood. The sensor involves a non-conductive base which provides a flow path for the body fluid with the base having a working and counter electrode on its surface which are in electrical communication with a detector of current. The base and a cover therefore provide a capillary space containing the electrodes into which the body fluid is drawn by capillary action. The counter electrode has a sub-element which contains an electroactive material and is configured in the system (sensor and meter) to provide an error signal when insufficient body fluid is drawn into the capillary.
摘要翻译： 公开了用于测定体液中的分析物的电化学传感器，例如， 葡萄糖在血液中 传感器包括非导电基座，其提供用于体液的流动路径，其中底座在其表面上具有与电流检测器电连通的工作电极和对电极。 因此，底座和盖子提供包含电极的毛细管空间，通过毛细管作用吸引体液。 对电极具有含有电活性材料的子元件，并且被配置在系统（传感器和仪表）中，以在不足的体液被吸入毛细管时提供错误信号。
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公开(公告)号：US08083884B2
公开(公告)日：2011-12-27
申请号：US12086240
申请日：2006-12-21
申请人： Andrew J. Edelbrock
发明人： Andrew J. Edelbrock
CPC分类号： C12Q1/001 , B23K26/38 , B23K2101/18 , B23K2101/20 , G01N27/3272 , Y10T156/1052 , Y10T156/1056 , Y10T156/1057 , Y10T156/1062 , Y10T156/1064
摘要： A method of forming an electrochemical multilayer test sensor that includes a base, a second layer and a reactive layer. The reactive area includes an enzyme. The test sensor is adapted to be used in a meter and assist in determining the concentration of an analyte. A plurality of electrodes and their respective conductive leads are partially defined on the base. After partially defining the plurality of electrodes and their respective conductive leads on the base, the base is attached to a second layer to define a reaction zone in which the plurality of electrodes are fully defined. After attaching the base to the second layer, the plurality of conductive leads on the base of the test sensor are fully defined.
摘要翻译： 一种形成电化学多层测试传感器的方法，其包括基底，第二层和反应层。 反应性区域包括酶。 测试传感器适用于仪表，有助于确定分析物的浓度。 多个电极及其各自的导电引线部分地限定在基座上。 在基底部分地限定多个电极及其各自的导电引线之后，将基座附接到第二层以限定其中多个电极被完全限定在其中的反应区域。 在将基座安装到第二层之后，在测试传感器的底部上的多个导电引线被完全限定。
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38.发明申请Process of Making Electrolessly Plated Auto-Calibration Circuits for Test Sensors 审中-公开制造无电镀自动校准电路的测试传感器的过程公开(公告)号：US20090142483A1
公开(公告)日：2009-06-04
申请号：US12086281
申请日：2006-12-21
申请人： Andrew J. Edelbrock
发明人： Andrew J. Edelbrock
IPC分类号： B05D5/12
CPC分类号： G01N33/48771
摘要： A method of forming an auto-calibration circuit to be used with a sensor package. The sensor package includes at least one test sensor and is adapted to be used with an instrument or meter. A substrate is provided. Catalytic ink or catalytic polymeric solution is applied to at least one side of the substrate to assist in defining electrical connections on the substrate. The substrate is electrolessly plated with the catalytic ink or catalytic polymeric solution to form the electrical connections of the substrate. The electrical connections convey auto-calibration information for the at least one test sensor to the instrument.
摘要翻译： 一种形成与传感器封装一起使用的自动校准电路的方法。 传感器封装包括至少一个测试传感器，并且适于与仪器或仪表一起使用。 提供基板。 将催化油墨或催化聚合物溶液施加到基材的至少一侧，以帮助限定基材上的电连接。 用催化油墨或催化聚合物溶液无电镀上基材以形成基材的电连接。 电气连接将至少一个测试传感器的自动校准信息传送到仪器。
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公开(公告)号：US20090038489A1
公开(公告)日：2009-02-12
申请号：US12084439
申请日：2006-11-27
申请人： Andrew J. Edelbrock
发明人： Andrew J. Edelbrock
IPC分类号： B41M1/12
CPC分类号： B41M1/12
摘要： A method of screen printing on a substrate comprises providing a screen including a first portion with an emulsion and a second portion formed without an emulsion. An ink solution is supplied on the screen. The ink solution comprises a solid and a liquid. The ink solution includes an enzyme to assist in determining an analyte concentration of a fluid sample. The ink solution contacts the substrate via the second portion of the screen. The ink solution is mechanically replenished in semi-continuous intervals from an ink-solution reservoir.
摘要翻译： 一种在基片上进行丝网印刷的方法包括提供包括具有乳液的第一部分和不具有乳液的第二部分的筛网。 在屏幕上提供墨水解决方案。 油墨溶液包括固体和液体。 油墨溶液包括有助于确定流体样品的分析物浓度的酶。 墨溶液经由屏幕的第二部分接触基板。 油墨溶液以半连续间隔从墨水储存器机械补充。
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公开(公告)号：US07125481B2
公开(公告)日：2006-10-24
申请号：US10864011
申请日：2004-06-09
IPC分类号： G01N27/327 , G01N27/333
CPC分类号： C12Q1/001 , G01N27/3274
摘要： An electrochemical test sensor adapted to assist in determining the concentration of analyte in a fluid sample is disclosed. The sensor comprises a base that assists in forming an opening for introducing the fluid sample, a working electrode being coupled to the base, and a counter electrode being coupled to the base, the counter electrode and the working electrode being adapted to be in electrical communication with a detector of electrical current, and a sub-element being coupled to the base. A major portion of the counter electrode is located downstream relative to the opening and at least a portion of the working electrode. The sub-element is located upstream relative to the working electrode such that when electrical communication occurs between only the sub-element and the working electrode there is insufficient flow of electrical current through the detector to determine the concentration of the analyte in the fluid sample.
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