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公开(公告)号：US20150005330A1
公开(公告)日：2015-01-01
申请号：US14485259
申请日：2014-09-12
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
IPC分类号： C07D471/20
CPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮羧酰胺氮杂茚衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20210403457A1
公开(公告)日：2021-12-30
申请号：US17347639
申请日：2021-06-15
发明人： Ashok Arasappan , Ian M. Bell , Christopher James Bungard , Christopher S. Burgey , Jason M. Cox , Michael J. Kelly, III , Mark E. Layton , Hong Liu , Jian Liu , James J. Perkins , Akshay A. Shah , Michael David VanHeyst , Zhe Wu
IPC分类号： C07D403/12 , C07D233/32 , C07D401/14 , C07D401/12 , C07D405/12 , C07D417/12 , C07D417/14 , C07D413/12 , C07D513/04 , C07D471/08 , C07D471/04
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.
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33.发明申请公开(公告)号：US20210196734A1
公开(公告)日：2021-07-01
申请号：US17193550
申请日：2021-03-05
发明人： Brendan M. Crowley , Ian M. Bell , Andrew John Harvey , Brian T. Campbell , Thomas J. Greshock , Vanessa L. Rada
IPC分类号： A61K31/695 , A61K31/198 , A61K31/4164 , A61K31/4196 , A61K31/4245 , A61K31/4418 , A61K31/4439 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/34 , C07D233/64 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/08 , C07D271/06 , C07D401/04 , C07D413/04 , C07F7/08
摘要： The present disclosure relates to compounds of formula I that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation
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公开(公告)号：US20210008055A1
公开(公告)日：2021-01-14
申请号：US16940943
申请日：2020-07-28
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
IPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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公开(公告)号：US20180092900A1
公开(公告)日：2018-04-05
申请号：US15830131
申请日：2017-12-04
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
IPC分类号： A61K31/4545 , C07D471/20 , A61K31/435 , A61K31/438 , C07D471/10
CPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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公开(公告)号：US09926285B2
公开(公告)日：2018-03-27
申请号：US15727982
申请日：2017-10-09
IPC分类号： C07D285/12 , C07D231/12 , C07D249/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/26 , C07D285/08 , A61K31/4192 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/433 , A61K31/415 , C07D271/107
CPC分类号： C07D285/12 , A61K31/415 , A61K31/4192 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/433 , C07D231/12 , C07D233/64 , C07D249/04 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/26 , C07D285/08 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/04 , C07D495/04
摘要： The present disclosure relates to compounds of formula I that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation
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公开(公告)号：US09833448B2
公开(公告)日：2017-12-05
申请号：US15293569
申请日：2016-10-14
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
IPC分类号： A01N43/42 , A61K31/44 , A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
CPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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公开(公告)号：US09227972B2
公开(公告)日：2016-01-05
申请号：US14399649
申请日：2013-05-03
发明人： Ian M. Bell , Mark Fraley , Tesfaye Biftu , Cheng Zhu , Anilkumar Nair , Helen Mitchell
IPC分类号： C07D471/20 , A61K31/45 , A61K31/451 , A61K31/4523 , A61K9/48
CPC分类号： C07D471/20 , A61K9/4858 , A61K31/45 , A61K31/451 , A61K31/4523
摘要： The present invention is directed to aliphatic spirolactam derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical\compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂并可用于治疗或预防涉及CGRP的疾病如偏头痛的脂族螺旋体衍生物。 本发明还涉及包含这些化合物的药物\组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US09409916B2
公开(公告)日：2016-08-09
申请号：US14005673
申请日：2012-03-14
申请人： Ian M. Bell , Justin Belardi
发明人： Ian M. Bell , Justin Belardi
IPC分类号： C07D487/10 , C07D471/10
CPC分类号： C07D487/10 , C07D471/10
摘要： The present invention is directed to piperidinone carboxamide spirohydantoin derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮甲酰胺螺乙内酰脲衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20120122900A1
公开(公告)日：2012-05-17
申请号：US13293177
申请日：2011-11-10
申请人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
IPC分类号： A61K31/437 , A61K31/527 , A61P25/06 , C07D471/20
CPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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