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公开(公告)号:US06638980B1
公开(公告)日:2003-10-28
申请号:US09576633
申请日:2000-05-24
IPC分类号: A61K31165
CPC分类号: C07D213/40 , C07C311/16 , C07C311/46 , C07D217/22 , C07D295/192 , C07D295/26 , C07D307/52 , C07D401/12
摘要: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号:US06245743B1
公开(公告)日:2001-06-12
申请号:US09077001
申请日:1998-05-15
IPC分类号: A61K3800
CPC分类号: C07K5/0202 , A61K38/00 , C07K5/06086 , C07K5/06095 , C07K5/0817
摘要: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译: 公开了与哺乳动物因子Xa具有活性的新型化合物,其盐和与其相关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号:US06211183B1
公开(公告)日:2001-04-03
申请号:US09058564
申请日:1998-04-13
IPC分类号: A61K3169
CPC分类号: C07D295/205 , C07D211/26 , C07D241/08 , C07D243/08 , C07D295/15 , C07D401/06 , C07D401/12 , C07D417/12 , C07D417/14
摘要: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号:US6046169A
公开(公告)日:2000-04-04
申请号:US486386
申请日:1995-06-07
CPC分类号: C07K5/06191 , A61K38/00
摘要: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译: 公开了与哺乳动物因子Xa具有活性的新型化合物,其盐和与其相关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号:US07312235B2
公开(公告)日:2007-12-25
申请号:US10115135
申请日:2002-04-01
申请人: Bing-Yan Zhu , Penglie Zhang , Erick A. Goldman , Zhaozhong Jon Jia , Shawn Bauer , Wenrong Huang , John Woolfrey , Robert M. Scarborough
发明人: Bing-Yan Zhu , Penglie Zhang , Erick A. Goldman , Zhaozhong Jon Jia , Shawn Bauer , Wenrong Huang , John Woolfrey , Robert M. Scarborough
IPC分类号: A61K31/497 , A61K31/445 , A61K31/44 , A61K31/00
CPC分类号: C07D213/75 , C07C237/42 , C07C255/57 , C07C257/18 , C07D205/04 , C07D211/22 , C07D211/26 , C07D211/34 , C07D211/62 , C07D233/22 , C07D233/64 , C07D295/13 , C07D295/195 , C07D307/54 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , G02B6/2746
摘要: Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian Factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译: 公开了与哺乳动物因子Xa具有活性的新型苯甲酰胺化合物,其盐和与其有关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号:US06211154B1
公开(公告)日:2001-04-03
申请号:US08480491
申请日:1995-06-07
IPC分类号: C07K508
CPC分类号: C07K5/06095 , A61K38/00
摘要: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译: 公开了与哺乳动物因子Xa具有活性的新型化合物,其盐和与其相关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号:US06197748B1
公开(公告)日:2001-03-06
申请号:US09077002
申请日:1998-05-15
IPC分类号: A61K3700
CPC分类号: C07K5/06 , A61K38/00 , C07K5/06078 , C07K5/06095 , C07K5/06139
摘要: Ketoheterocyclic compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are usefull in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译: 公开了具有针对哺乳动物因子Xa的活性的酮类杂环化合物,其盐和与其相关的组合物。 这些化合物在体外或体内是有用的用于预防或治疗凝血障碍。
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公开(公告)号:US06022861A
公开(公告)日:2000-02-08
申请号:US486213
申请日:1995-06-07
CPC分类号: C07K5/06086 , A61K38/00
摘要: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号:US20060160821A1
公开(公告)日:2006-07-20
申请号:US11298317
申请日:2005-12-07
申请人: Yonghong Song , Bing-Yan Zhu , Shumei Wang , Chhaya Bhakta , Robert Scarborough
发明人: Yonghong Song , Bing-Yan Zhu , Shumei Wang , Chhaya Bhakta , Robert Scarborough
IPC分类号: A61K31/496 , A61K31/4709 , A61K31/454 , A61K31/4015 , C07D403/02 , C07D401/02
CPC分类号: C07D213/40 , C07C275/30 , C07D211/26 , C07D211/58 , C07D213/64 , C07D213/74 , C07D213/89 , C07D215/227 , C07D233/24 , C07D233/64 , C07D243/08 , C07D263/04 , C07D265/32 , C07D277/04 , C07D295/195 , C07D333/22 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04
摘要: The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译: 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐,溶剂合物,水合物和前药。 本发明还涉及用于制备这种化合物的中间体,含有这些化合物的药物组合物,预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号:US20060020039A1
公开(公告)日:2006-01-26
申请号:US11035767
申请日:2005-01-14
申请人: Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert Scarborough
发明人: Bing-Yan Zhu , Penglie Zhang , Lingyan Wang , Wenrong Huang , Erick Goldman , Wenhao Li , Jingmei Zuckett , Yonghong Song , Robert Scarborough
IPC分类号: A61K31/54 , A61K31/537 , A61K31/445 , A61K31/4172 , A61K31/40 , A61K31/397
CPC分类号: C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要: Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译: 公开了与哺乳动物因子Xa有活性的新型苯甲酰胺化合物,其盐和与其有关的组合物。 该化合物在体外或体内可用于预防或治疗凝血障碍。
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