EXPANDABLE MEDICAL ACCESS SHEATH
    31.
    发明申请
    EXPANDABLE MEDICAL ACCESS SHEATH 有权
    可扩展医疗通道

    公开(公告)号:US20080200943A1

    公开(公告)日:2008-08-21

    申请号:US11952883

    申请日:2007-12-07

    IPC分类号: A61M29/00

    CPC分类号: A61B17/3439 A61B17/3431

    摘要: An expandable medical sheath is configured to be introduced into a body in a first, low cross-sectional area configuration, and expanded to a second, enlarged cross-sectional configuration. The sheath is maintained in the first, low cross-sectional configuration by structures or elements within the sheath wall that maintain a collapsed shape. Upon expansion with a dilator, the sheath maintains a second, enlarged cross-sectional configuration by elements or structures within the sheath tubing wall that resist re-collapse. The sheath includes a nose cone or tapered fairing to deflect tissue from entering the collapsed distal end of the sheath during introduction. The fairing collapses following expansion and subsequent deflation of the dilator, thus allowing the tapered fairing to be withdrawn proximally through the central lumen of the sheath. In one application, the sheath is utilized to provide access for a diagnostic or therapeutic procedure such as percutaneous nephrostomy or urinary bladder access.

    摘要翻译: 可扩张医疗护套被构造成以第一低截面区域构造被引入体内,并且扩张到第二扩大横截面构型。 护套通过保护塌陷形状的护套壁内的结构或元件保持在第一低截面形状。 在用扩张器膨胀时,护套通过护套管壁内的元件或结构保持第二,扩大的横截面构型,抵抗再崩溃。 护套包括鼻锥体或锥形整流罩,以在引入期间使组织偏转进入护套的塌陷的远端。 整流罩在扩张器膨胀和随后放气之后塌陷,从而允许锥形整流罩通过护套的中心内腔向近侧撤回。 在一个应用中,护套用于提供用于诊断或治疗程序的通路,例如经皮肾造瘘术或膀胱通路。

    Phosphocholine linked prodrug derivatives
    32.
    发明申请
    Phosphocholine linked prodrug derivatives 审中-公开
    磷酸胆碱连接的前药衍生物

    公开(公告)号:US20060166903A1

    公开(公告)日:2006-07-27

    申请号:US11386991

    申请日:2006-03-21

    IPC分类号: C07J17/00 A61K31/66 C07J51/00

    摘要: Disclosed are compounds of general formula (I) that function as prodrugs, thereby increasing bioavailabilities of the linked therapeutic agents, wherein the LINKER is (i) substituted or unsubstituted alkyl, (ii) substituted or unsubstituted alkenyl, (iii) substituted or unsubstituted alkanoyl, (iv) substituted or unsubstituted alkenoyl wherein the double bond is cis, and (v) (ortho or para) carbonyl-substituted aryl; and wherein the substituent is each an independent group or linked together thereby forming a ring; and wherein X is one or more substituted or unsubstituted group containing one or more O, N, or S atom and wherein the substituent is each an independent group or linked together thereby forming a ring; and wherein the therapeutic agent is an alcohol-containing water-insoluble steroids or another alcohol containing compounds and methods to prepare such compounds.

    摘要翻译: 公开了作为前药的通式(I)化合物,从而提高连接的治疗剂的生物利用度,其中LINKER是(i)取代或未取代的烷基,(ii)取代或未取代的烯基,(iii)取代或未取代的烷酰基 ,(iv)取代或未取代的链烯基,其中双键是顺式的,和(v)(邻或对)羰基取代的芳基; 并且其中所述取代基各自为独立基团或连接在一起形成环; 并且其中X是一个或多个取代或未取代的含有一个或多个O,N或S原子的基团,并且其中所述取代基各自为独立基团或连接在一起形成环; 并且其中所述治疗剂是含醇的水不溶性类固醇或其它含醇的化合物和制备所述化合物的方法。

    Electronic content publication management system and method
    33.
    发明申请
    Electronic content publication management system and method 审中-公开
    电子内容出版管理系统及方法

    公开(公告)号:US20060107198A1

    公开(公告)日:2006-05-18

    申请号:US10521414

    申请日:2003-07-11

    IPC分类号: G06F17/21 G06F17/30

    CPC分类号: G06F16/958

    摘要: An electronic content publication management system (1) for publishing content to one or more electronically accessible sites, each site including at least one electronic page (40), the system comprising content database means (2) for storing a plurality of content objects (3); content management database means (4) for storing a data structure (5) identifying each electronic page, one or more content pools (52, 59) within each page and one or more content objects (57, 58, 63, 64) within each page, wherein the data structure identifies one or more nested content pools or content objects within each content pool; and electronic page assembly means (10, 11, 12) for generating one or more completed electronic pages for each site using the stored data structure and stored content objects.

    摘要翻译: 一种用于将内容发布到一个或多个电子可访问站点的电子内容发布管理系统(1),每个站点包括至少一个电子页面(40),所述系统包括用于存储多个内容对象(3)的内容数据库装置(2) ); 内容管理数据库装置(4),用于存储识别每个电子页面的数据结构(5),每个页面内的一个或多个内容池(52,59)和每个页面内的一个或多个内容对象(57,58,63,64) 页面,其中所述数据结构标识每个内容池中的一个或多个嵌套内容池或内容对象; 以及用于使用所存储的数据结构和存储的内容对象为每个站点生成一个或多个完成的电子页面的电子页面组装装置(10,11,12)。