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    Phosphocholine linked prodrug derivatives
    1.
    发明申请
    Phosphocholine linked prodrug derivatives 审中-公开
    磷酸胆碱连接的前药衍生物

    公开(公告)号：US20060166903A1

    公开(公告)日：2006-07-27

    申请号：US11386991

    申请日：2006-03-21

    Applicant: Bruce Morimoto ,  Peter Barker

    Inventor： Bruce Morimoto ,  Peter Barker

    IPC: C07J17/00 ,  A61K31/66 ,  C07J51/00

    CPC classification number: C07F9/091 ,  A61K9/0019 ,  A61K9/08 ,  A61K47/544

    Abstract: Disclosed are compounds of general formula (I) that function as prodrugs, thereby increasing bioavailabilities of the linked therapeutic agents, wherein the LINKER is (i) substituted or unsubstituted alkyl, (ii) substituted or unsubstituted alkenyl, (iii) substituted or unsubstituted alkanoyl, (iv) substituted or unsubstituted alkenoyl wherein the double bond is cis, and (v) (ortho or para) carbonyl-substituted aryl; and wherein the substituent is each an independent group or linked together thereby forming a ring; and wherein X is one or more substituted or unsubstituted group containing one or more O, N, or S atom and wherein the substituent is each an independent group or linked together thereby forming a ring; and wherein the therapeutic agent is an alcohol-containing water-insoluble steroids or another alcohol containing compounds and methods to prepare such compounds.

    Abstract translation: 公开了作为前药的通式（I）化合物，从而提高连接的治疗剂的生物利用度，其中LINKER是（i）取代或未取代的烷基，（ii）取代或未取代的烯基，（iii）取代或未取代的烷酰基 ，（iv）取代或未取代的链烯基，其中双键是顺式的，和（v）（邻或对）羰基取代的芳基; 并且其中所述取代基各自为独立基团或连接在一起形成环; 并且其中X是一个或多个取代或未取代的含有一个或多个O，N或S原子的基团，并且其中所述取代基各自为独立基团或连接在一起形成环; 并且其中所述治疗剂是含醇的水不溶性类固醇或其它含醇的化合物和制备所述化合物的方法。

    Intravascular catheter with heat exchange element having inner inflation element and methods of use
    7.
    发明授权
    Intravascular catheter with heat exchange element having inner inflation element and methods of use 有权
    具有内部充气元件的热交换元件和使用方法的血管内导管

    公开(公告)号：US06716236B1

    公开(公告)日：2004-04-06

    申请号：US10045936

    申请日：2001-10-19

    Applicant: Elbert Tzeng ,  Peter Barker ,  Scott M. Evans ,  Wayne A. Noda

    Inventor： Elbert Tzeng ,  Peter Barker ,  Scott M. Evans ,  Wayne A. Noda

    IPC: A61F700

    CPC classification number: A61F7/12 ,  A61M25/1011

    Abstract: An intravenous catheter system (apparatus and method) for controlling patient temperature includes a generally tubular elongate body, a heat exchange element through which a heat exchange fluid circulates, and an inflation element or irregular surface positioned within the heat exchange element for promoting mixing of the circulating heat exchange fluid. The heat exchange element and inflation element preferably include inflatable balloons. The catheter preferably has two to four balloons having a substantially straight configuration, each balloon containing an inner balloon inflation element having a substantially spiral configuration. The catheter also preferably has at least one infusion lumen for providing access to the patient's blood and a guidewire lumen to accommodate a guidewire. The catheter is used in conjunction with a heat/cool system to cool a hyperthermic patient as quickly as possible, to warm a hypothermic patient as quickly as possible or to maintain normothermia.

    Abstract translation: 用于控制患者体温的静脉内导管系统（装置和方法）包括大致管状的细长体，热交换流体循环通过的热交换元件和位于热交换元件内的充气元件或不规则表面，用于促进 循环热交换流体。 热交换元件和充气元件优选地包括可充气气球。 导管优选地具有两至四个具有基本上直的构造的气囊，每个球囊包含具有基本上螺旋形构造的内球囊膨胀元件。 导管还优选地具有至少一个用于提供对患者血液的通路和用于容纳导丝的导丝管腔的输液腔。 导管与热/冷系统一起使用以尽可能快地冷却高热患者，以尽可能快地温热低温患者或维持正常体温。

    Multiple Trade Matching Algorithms
    9.
    发明申请
    Multiple Trade Matching Algorithms 审中-公开
    多重贸易匹配算法

    公开(公告)号：US20140006243A1

    公开(公告)日：2014-01-02

    申请号：US13534399

    申请日：2012-06-27

    Applicant: James Boudreault ,  Frederick Storm ,  John Labuszewski ,  Daniel Grombacher ,  Jonathan Kronstein ,  Peter Barker ,  Suzanne Spain

    Inventor： James Boudreault ,  Frederick Storm ,  John Labuszewski ,  Daniel Grombacher ,  Jonathan Kronstein ,  Peter Barker ,  Suzanne Spain

    IPC: G06Q40/04

    CPC classification number: G06Q40/04

    Abstract: The disclosed embodiments relate to systems and methods which match/allocate an incoming order to trade with “resting,” i.e. previously received but not yet matched, orders, recognizing that the algorithm or rules by which the incoming order is matched may affect the operation of the market for the financial product being traded. In particular, the disclosed embodiments relate to an adaptive match engine which draws upon different matching algorithms, e.g. the rules which dictate how a given order should be allocated among qualifying resting orders, depending upon market conditions, to improve the operation of the market. Thereby, by conditionally switching among matching algorithms within the same financial product, as will be described, the disclosed match engine automatically adapts to the changing market conditions of a financial product, e.g. a limited life product, in a non-preferential manner, maintaining fair order allocation while improving market liquidity, e.g., over the life of the product.

    Abstract translation: 所公开的实施例涉及系统和方法，其匹配/分配进入的订单以“休息”交易，即先前接收但尚未匹配的订单，认识到输入订单匹配的算法或规则可能影响 金融产品交易市场。 特别地，所公开的实施例涉及一种自适应匹配引擎，其基于不同的匹配算法，例如， 规定如何根据市场条件在合格休息令中分配给定的订单以改善市场运作。 因此，如上所述，通过有条件地在相同的金融产品中的匹配算法之间切换，所公开的匹配引擎自动地适应金融产品的变化的市场状况，例如， 有限的生活产品以非优先的方式维持公平的订单分配，同时提高市场流动性，例如在产品的使用寿命内。

    COMPOUND OVERNIGHT BANK RATE ACCRUAL FUTURES CONTRACT AND COMPUTATION OF VARIATION MARGIN THEREFORE
    10.
    发明申请
    COMPOUND OVERNIGHT BANK RATE ACCRUAL FUTURES CONTRACT AND COMPUTATION OF VARIATION MARGIN THEREFORE 审中-公开
    化合物银行汇率变动后期合约及其变动计算

    公开(公告)号：US20130179319A1

    公开(公告)日：2013-07-11

    申请号：US13348251

    申请日：2012-01-11

    Applicant: Peter Barker ,  James Boudreault ,  Daniel Grombacher ,  Michael P. Kamradt ,  Frederick Sturm ,  John Labuszewski

    Inventor： Peter Barker ,  James Boudreault ,  Daniel Grombacher ,  Michael P. Kamradt ,  Frederick Sturm ,  John Labuszewski

    IPC: G06Q40/04

    CPC classification number: G06Q40/04

    Abstract: The disclosed embodiments relate to an exchange-traded futures contract, guaranteed by a clearing house, and characterized by an embedded price dynamic comprising a compound accrual of a periodic interest rate up to a date on which trading therein is terminated, as specified in the futures contract terms and conditions. A trader may be allowed and/or enabled to take a position in a futures contract with respect to an interest bearing underlier with a variable interest rate and, thereby, minimize the number of transactions and attendant costs with respect to monitoring and correcting for divergences between the futures position and the notional interest rate swap exposure for which the futures position is intended to serve as a proxy. Variation margin for the position is computed based on an underlying reference interest rate as opposed to being computed solely on the basis of the end-of-business day price of the futures contract.

    Abstract translation: 所披露的实施例涉及由结算所担保的交易所交易期货合约，其特征在于嵌入式价格动态，其包括在期货交易截止日期之前应计的定期利率的复合，如期货 合同条款和条件。 交易者可能被允许和/或能够在具有可变利率的利率低于期权的期货合约中担任职位，从而最大限度地减少交易数量和伴随成本，以监测和纠正两者之间的差异 期货头寸和期货头寸旨在作为代理人的名义利率掉期敞口。 基于相关参考利率计算头寸的变动幅度，而不是仅根据期货合约的工作结束日价格计算。

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