公开(公告)号：US06265401B1

公开(公告)日：2001-07-24

申请号：US09085292

申请日：1998-05-27

申请人： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Ashok Channaveerappa Bajji ,  Shivaramayya Kalchar ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

发明人： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Ashok Channaveerappa Bajji ,  Shivaramayya Kalchar ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

IPC分类号： A61K31538

CPC分类号： C07D265/36 ,  A61K31/5415 ,  C07D279/16

摘要： Compounds of formula (I) its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates can be used to prevent or treat diabetes caused by insulin resistance or impaired glucose tolerance or complications of diabetes caused by insulin resistance or impaired glucose tolerance. The compounds can also be used to reduce cholesterol, body weight, blood glucose, triglycerides and free fatty acids in the blood.

摘要翻译： 式（I）化合物其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐或其药学上可接受的溶剂化物可用于预防或治疗由胰岛素抵抗或糖耐量受损或由胰岛素抵抗引起的糖尿病并发症引起的糖尿病， 葡萄糖耐量降低。 该化合物也可用于降低血液中的胆固醇，体重，血糖，甘油三酯和游离脂肪酸。

公开(公告)号：US6030973A

公开(公告)日：2000-02-29

申请号：US135566

申请日：1998-08-17

申请人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

发明人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

IPC分类号： C07D265/22 ,  C07D277/20 ,  C07D277/34 ,  C07D413/12 ,  C07D417/12 ,  A61K31/505 ,  C07D239/91 ,  C07D239/92 ,  C07D279/08

CPC分类号： C07D417/12 ,  C07D265/22 ,  C07D277/20 ,  C07D277/34 ,  C07D413/12

摘要： The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their analogues, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinediones of the general formula (I), their analogues, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. ##STR1##

摘要翻译： 本发明涉及新型抗糖尿病化合物，其互变异构形式，其衍生物，其类似物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和含有它们的药学上可接受的组合物。 本发明特别涉及通式（I）的新型氮杂二醇，其类似物，其衍生物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，药学上可接受的溶剂合物和含有它们的药物组合物。

公开(公告)号：US5985884A

公开(公告)日：1999-11-16

申请号：US884816

申请日：1997-06-30

申请人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Ranga Madhavan Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Sarma K. S. Pakala

发明人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Ranga Madhavan Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Sarma K. S. Pakala

IPC分类号： A61K31/417 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/497 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61P3/00 ,  A61P3/06 ,  A61P3/10 ,  C07D239/00 ,  C07D239/36 ,  C07D239/46 ,  C07D239/88 ,  C07D263/00 ,  C07D271/00 ,  C07D277/00 ,  C07D277/34 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  A61K31/505 ,  C07D239/02 ,  C07D241/00

CPC分类号： C07D239/36 ,  C07D239/47 ,  C07D239/88 ,  C07D277/34 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04

摘要： The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. ##STR1##

公开(公告)号：US5919782A

公开(公告)日：1999-07-06

申请号：US851447

申请日：1997-05-05

申请人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Paraselli Bheema Rao ,  Sekar Reddy Alla ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

发明人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Paraselli Bheema Rao ,  Sekar Reddy Alla ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

IPC分类号： C07D417/14 ,  C07D417/12 ,  A61K31/425

CPC分类号： C07D417/14

摘要： Novel antidiabetic compounds, their tautomeric forms, their derivatives, their steroisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceuticals acceptable compositions containing them; methods for preparing the antidiabetic compounds and their uses.

摘要翻译： 新型抗糖尿病化合物，其互变异构形式，其衍生物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和药物可接受的组合物含有它们; 制备抗糖尿病化合物的方法及其用途。

公开(公告)号：US5801173A

公开(公告)日：1998-09-01

申请号：US687840

申请日：1996-07-26

申请人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Sekar Reddy Alla ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

发明人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Sekar Reddy Alla ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

IPC分类号： C07D417/14 ,  C07D417/12 ,  A61K31/425

CPC分类号： C07D417/14

摘要： Novel antidiabetic compounds, their tautomeric forms, their derivatives, their steroisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceuticaly acceptable compositions containing them; methods for preparing the antidiabetic compounds and their uses.

摘要翻译： 新型抗糖尿病化合物，其互变异构形式，其衍生物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物; 制备抗糖尿病化合物的方法及其用途。

公开(公告)号：US08030345B2

公开(公告)日：2011-10-04

申请号：US11632236

申请日：2005-07-08

申请人： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Brijesh Srivastava

发明人： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Brijesh Srivastava

IPC分类号： A61K31/38 ,  C07D495/02

CPC分类号： C07D495/14 ,  C07D495/04

摘要： The present invention relates to novel compounds of general formula (I), their regioisomers, tautomeric forms, novel intermediates involved in their synthesis. The present invention also relates to a process of preparing compounds of general formula (I), their regioisomers, their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

摘要翻译： 本发明涉及通式（I）的新型化合物，其区域异构体，互变异构体，涉及其合成的新型中间体。 本发明还涉及制备通式（I）的化合物，其区域异构体，其互变异构形式，其药学上可接受的盐，含有它们的药物组合物以及参与其合成的新中间体的方法。

公开(公告)号：US08022217B2

公开(公告)日：2011-09-20

申请号：US12374089

申请日：2007-07-27

申请人： Pravin S. Thombare ,  Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Pankaj Ramanbhai Patl

发明人： Pravin S. Thombare ,  Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Pankaj Ramanbhai Patl

IPC分类号： C07D215/38

CPC分类号： C07C237/30 ,  C07C2601/14 ,  C07D215/48 ,  C07D405/12

摘要： Disclosed herein in the embodiments of the present invention are the compounds suitable as modulators of HDL having general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

摘要翻译： 在本发明的实施方案中公开的是适合作为具有通式（1）的HDL的调节剂的化合物，涉及其合成的新中间体，其药学上可接受的盐和含有它们的药物组合物。 本发明还涉及制备通式（1）的化合物，其互变异构形式，其药学上可接受的盐，含有它们的药物组合物和参与其合成的新中间体的方法。

公开(公告)号：US20100240709A1

公开(公告)日：2010-09-23

申请号：US12086282

申请日：2006-12-11

申请人： Shanker Jayram Shetty ,  Gautam D. Patel ,  Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Ganes Chakrabarti ,  Abhijit Chatterjee ,  Mukul R. Jain ,  Pankaj Ramanbhai Patel

发明人： Shanker Jayram Shetty ,  Gautam D. Patel ,  Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Ganes Chakrabarti ,  Abhijit Chatterjee ,  Mukul R. Jain ,  Pankaj Ramanbhai Patel

IPC分类号： A61K31/4439 ,  C07D417/04 ,  C07D417/14 ,  A61P29/00

CPC分类号： C07D417/04

摘要： The present invention relates to novel compounds of general formula (I), their regioisomers, tautomeric forms, novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (I), their regioisomers, their tautomeric forms, their pharmaceutically acceptable salts pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

摘要翻译： 本发明涉及通式（I）的新型化合物，其区域异构体，互变异构形式，涉及其合成的新中间体，其药学上可接受的盐和含有它们的药物组合物。 本发明还涉及制备通式（I）的化合物，其区域异构体，其互变异构形式，其药学上可接受的盐含有它们的药物组合物和涉及其合成的新中间体的方法。

公开(公告)号：US07348426B1

公开(公告)日：2008-03-25

申请号：US09959093

申请日：2000-04-25

申请人： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Ashok Channaveerappa Bajji ,  Shivaramayya Kalchar ,  Ranga Madhavan Gurram ,  Ramanujam Rajagopalan ,  Chakrabarti Ranjan

发明人： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Ashok Channaveerappa Bajji ,  Shivaramayya Kalchar ,  Ranga Madhavan Gurram ,  Ramanujam Rajagopalan ,  Chakrabarti Ranjan

IPC分类号： A61K31/538 ,  C07D265/36 ,  C07D279/16 ,  A61P3/06

CPC分类号： C07D413/06 ,  C07D265/36 ,  C07D279/16 ,  C07D417/06

摘要： The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel β-aryl-α-oxysubstituted alkylcarboxylic acids of general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them

摘要翻译： 本发明涉及新型抗肥胖和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 更具体地，本发明涉及通式（I）的新型β-芳基-α-氧代取代的烷基羧酸，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物 和含有它们的药学上可接受的组合物

公开(公告)号：US06780992B2

公开(公告)日：2004-08-24

申请号：US10032846

申请日：2001-12-26

申请人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Ranga Madhavan Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Sarma K.S. Pakala

发明人： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Ranga Madhavan Gurram ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti ,  Sarma K.S. Pakala

IPC分类号： C07D23510

CPC分类号： C07D239/36 ,  C07D239/47 ,  C07D239/88 ,  C07D277/34 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04

摘要： The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them.

摘要翻译： 本发明涉及新的抗糖尿病化合物，其互变异构形式，其衍生物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 本发明特别涉及通式（I）的新的唑来二酮衍生物及其药学上可接受的盐，药学上可接受的溶剂合物和含有它们的药物组合物。