公开(公告)号：US20230419488A1

公开(公告)日：2023-12-28

申请号：US18457050

申请日：2023-08-28

Applicant: Cleerly, Inc.

Inventor： James K. Min ,  James P. Earls ,  Shant Malkasian ,  Hugo Miguel Rodrigues Marques ,  Chung Chan ,  Shai Ronen

IPC: G06T7/00 ,  G06T7/62 ,  A61B5/00

CPC classification number: G06T7/0012 ,  G06T7/62 ,  A61B5/7275 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/10081 ,  G06T2207/20081 ,  G06T2207/10116 ,  G06T2207/10048 ,  G06T2207/30101 ,  G06T2207/10132 ,  G06T2207/10101

Abstract: Systems and methods of facilitating determination of risk of coronary artery disease (CAD) based at least in part on one or more measurements derived from non-invasive medical image analysis. The methods can include accessing a non-invasive generated medical image, identifying one or more arteries, identifying, regions of plaque within an artery, analyzing the regions of plaque to identify low density non-calcified plaque, non-calcified plaque, or calcified plaque based at least in part on density, determining a distance from identified regions of low density non-calcified plaque to one or more of a lumen wall or vessel wall, determining embeddedness of the regions of low density non-calcified plaque by one or more of non-calcified plaque or calcified plaque, determining a shape of the more regions of low density non-calcified plaque, and generating a display of the analysis to facilitate determination of one or more of a risk of CAD of the subject.

公开(公告)号：US20230401710A1

公开(公告)日：2023-12-14

申请号：US18456329

申请日：2023-08-25

Applicant: Cleerly, Inc.

Inventor： James K. Min ,  James P. Earls ,  Shant Malkasian ,  Hugo Miguel Rodrigues Marques ,  Chung Chan ,  Shai Ronen

IPC: G06T7/00 ,  G06T7/62 ,  A61B5/00

CPC classification number: G06T7/0012 ,  G06T7/62 ,  A61B5/7275 ,  G06T2207/10081 ,  G06T2207/10108 ,  G06T2207/10101 ,  G06T2207/30101 ,  G06T2207/10132 ,  G06T2207/10048 ,  G06T2207/20081 ,  G06T2207/10104 ,  G06T2207/10116

Abstract: Systems and methods of facilitating determination of risk of coronary artery disease (CAD) based at least in part on one or more measurements derived from non-invasive medical image analysis. The methods can include accessing a non-invasive generated medical image, identifying one or more arteries, identifying, regions of plaque within an artery, analyzing the regions of plaque to identify low density non-calcified plaque, non-calcified plaque, or calcified plaque based at least in part on density, determining a distance from identified regions of low density non-calcified plaque to one or more of a lumen wall or vessel wall, determining embeddedness of the regions of low density non-calcified plaque by one or more of non-calcified plaque or calcified plaque, determining a shape of the more regions of low density non-calcified plaque, and generating a display of the analysis to facilitate determination of one or more of a risk of CAD of the subject.

公开(公告)号：US20230147995A1

公开(公告)日：2023-05-11

申请号：US18149006

申请日：2022-12-30

Applicant: CLEERLY, INC.

Inventor： James K. Min ,  James P. Earls ,  Hugo Miguel Rodrigues Marques ,  Shant Malkasian ,  Ben Hootnick

IPC: G06T7/00 ,  A61B8/14 ,  A61B6/00 ,  A61B6/03 ,  A61B5/00 ,  A61B8/12 ,  A61B5/055 ,  A61K49/04 ,  G06F18/10

CPC classification number: G06T7/0012 ,  A61B8/14 ,  A61B6/481 ,  A61B6/037 ,  A61B6/5205 ,  A61B5/0066 ,  A61B6/032 ,  A61B8/12 ,  A61B5/7267 ,  A61B5/7475 ,  A61B6/504 ,  A61B5/055 ,  A61B5/742 ,  A61B5/0075 ,  A61K49/04 ,  G06F18/10 ,  G06T2207/10081 ,  G06T2207/10101 ,  G06T2207/30101 ,  G06T2207/30048 ,  G06T2207/20081 ,  G06T2207/10088 ,  G06T2207/10132

Abstract: The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.