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公开(公告)号：US20170056388A1
公开(公告)日：2017-03-02
申请号：US15257275
申请日：2016-09-06
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: A61K31/4545
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
Abstract translation: 本文提供了用于调节甲基修饰酶的组合物及其用途。
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公开(公告)号：US09522920B2
公开(公告)日：2016-12-20
申请号：US14313148
申请日：2014-06-24
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Victor S. Gehling , Jean-Christophe Harmange , Michael Charles Hewitt , Yves Leblanc , Christopher G. Nasveschuk , Alexander M. Taylor , Rishi G. Vaswani
IPC: A61K31/55 , C07D498/04 , C07D498/14 , C07D498/20 , C07D498/22 , C07K14/47 , A61K31/424
CPC classification number: C07D498/04 , A61K31/424 , A61K31/55 , C07D498/14 , C07D498/20 , C07D498/22 , C07K14/4702
Abstract: The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US20160333016A1
公开(公告)日：2016-11-17
申请号：US15155749
申请日：2016-05-16
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D487/04 , C07D405/14 , C07D401/14 , C07D401/12 , C07D471/04
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号：US09371331B2
公开(公告)日：2016-06-21
申请号：US14661797
申请日：2015-03-18
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew S. Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: A61K31/535 , C07D401/00 , C07D487/04 , C07D401/14 , C07D401/12 , C07D417/04 , C07D417/14 , C07D405/14 , C07D409/06 , C07D471/04
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号：US20240116905A1
公开(公告)日：2024-04-11
申请号：US18140730
申请日：2023-04-28
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Alexandre Côté , Victor S. Gehling , Avinash Khanna , Ludivine Moine , Jacob I. Stuckey
IPC: C07D405/14 , A61P35/00 , C07D405/12
CPC classification number: C07D405/14 , A61P35/00 , C07D405/12
Abstract: Provided are novel compounds of Formula (I):
and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.-
Patent Agency Ranking
公开(公告)号：US20220079917A1
公开(公告)日：2022-03-17
申请号：US17241315
申请日：2021-04-27
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Francois Brucelle , Victor S. Gehling , Avinash Khanna
IPC: A61K31/397 , A61P31/22 , A61P31/18 , A61P35/02 , A61K31/438 , C07D205/12 , C07D221/20 , A61P35/00
Abstract: Provided are novel compounds of Formula (I or Ia′): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I or Ia′), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.
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公开(公告)号：US20200306223A1
公开(公告)日：2020-10-01
申请号：US16671559
申请日：2019-11-01
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Francois Brucelle , Victor S. Gehling , Avinash Khanna
IPC: A61K31/397 , A61P31/22 , A61P31/18 , A61P35/02 , A61K31/438 , C07D205/12 , C07D221/20 , A61P35/00
Abstract: Provided are novel compounds of Formula (I or Ia′): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I or Ia′), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.
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公开(公告)号：US10517849B2
公开(公告)日：2019-12-31
申请号：US16345011
申请日：2017-10-26
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Francois Brucelle , Victor S. Gehling , Avinash Khanna
IPC: C07D221/20 , C07D205/12 , A61K31/397 , A61K31/438 , A61P35/02 , A61P31/22 , A61P31/18
Abstract: Provided are novel compounds of Formula (I or Ia′): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I or Ia′), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.
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公开(公告)号：US20190274998A1
公开(公告)日：2019-09-12
申请号：US16345011
申请日：2017-10-26
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Francois Brucelle , Victor S. Gehling , Avinash Khanna
IPC: A61K31/397 , A61K31/438 , A61P31/18 , A61P31/22 , A61P35/02
Abstract: Provided are novel compounds of Formula (I or Ia′): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I or Ia′), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.
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公开(公告)号：USRE47428E1
公开(公告)日：2019-06-11
申请号：US15878663
申请日：2018-01-24
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Les A. Dakin , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D401/12 , C07D401/14 , C07D487/04 , C07D417/04 , C07D417/14 , C07D405/14 , C07D471/04 , C07D409/06 , A61K31/4545
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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