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公开(公告)号:US4806569A
公开(公告)日:1989-02-21
申请号:US45545
申请日:1987-05-04
Applicant: David F. Horrobin
Inventor: David F. Horrobin
IPC: A61K31/19 , A23D9/00 , A23L1/30 , A23L1/325 , A23L1/48 , A61K31/16 , A61K31/20 , A61K31/22 , A61K31/23 , A61K31/557 , A61K35/56 , A61K35/60 , A61K36/00 , A61K36/185 , A61K38/00 , A61P3/08 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/30 , A61P27/16 , A61P35/00 , A61P37/08
CPC classification number: A61K35/60 , A23D9/00 , A61K31/20 , A61K31/23 , A61K31/557 , A61K36/185 , Y10S514/861 , Y10S514/866
Abstract: A method of treatment of atopic disorders, including eczema, asthma, allergies (especially allergic rhinitis), migraine and disorders associated with atopy including Crohn's disease, ulcerative colitis, otitis media, nephrotic syndrome, or benign breast disease, or breast or other cancer, or diabetes, or alcoholism, with effective amounts of one or more of the metabolites of linoleic acid (GLA, DGLA, AA, 22:4n-6 or 22:5n-6) and one or more of the metabolites of .alpha.-linolenic acid (18:4n-3), 20:4n-3, 20:5n-3, 22:5n-3 or 22:6n-3) are administered as such or in the form of an ester, salt, amide or other derivative convertible in the body thereto along or in an acceptable pharmaceutical carrier or diluent.
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公开(公告)号:US4738853A
公开(公告)日:1988-04-19
申请号:US719953
申请日:1985-04-04
Applicant: David F. Horrobin
Inventor: David F. Horrobin
CPC classification number: A23K50/75 , A23K20/158 , Y10S426/807
Abstract: A method of maintaining hens or other domesticated birds for egg production, comprises giving the birds feed supplemented with .gamma.-linolenic acid or one or more higher acids in the n-6 series, in the form of the free acid or as an ester, amide, phospholipid, salt or other physiologically acceptable derivative convertible in the bird's body to, or having the effect of, the free acid.
Abstract translation: 维持母鸡或其他驯养的鸡用于产蛋的方法包括以游离酸形式或作为酯酰胺给予在n-6系列中补充有γ-亚麻酸或一种或多种高级酸的鸟饲料 ,磷脂,盐或其他生理学上可接受的衍生物在鸟体内转化为或具有游离酸的作用。
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公开(公告)号:US4302447A
公开(公告)日:1981-11-24
申请号:US89293
申请日:1979-10-30
Applicant: David F. Horrobin
Inventor: David F. Horrobin
IPC: A61K31/43 , A61K31/545 , A61K33/30 , A61K31/20 , A61K31/54
CPC classification number: A61K31/545 , A61K31/43 , A61K33/30 , Y10S514/825 , Y10S514/899 , Y10S514/909
Abstract: Compositions and use of .gamma.-linolenic acids and related materials alone or with zinc and or .beta.-lactam antibiotics to treat schizophrenia, obesity, menstrual disorders, skin disorders and other conditions, and .beta.-lactam antibiotics alone to treat schizophrenia.
Abstract translation: 单独或与锌和/或β-内酰胺抗生素一起使用γ-亚麻酸和相关材料来治疗精神分裂症,肥胖症,月经失调,皮肤病和其他病症,以及单独使用β-内酰胺类抗生素治疗精神分裂症。
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公开(公告)号:US4273763A
公开(公告)日:1981-06-16
申请号:US4924
申请日:1979-01-19
Applicant: David F. Horrobin
Inventor: David F. Horrobin
IPC: A61K31/43 , A61K31/545 , A61K33/30 , A61K31/20 , A61K31/315 , A61K31/54
CPC classification number: A61K31/545 , A61K31/43 , A61K33/30 , Y10S514/825 , Y10S514/899 , Y10S514/909
Abstract: Compositions and use of .gamma.-linolenic acids and related materials alone or with zinc and or .beta.-lactam antibiotics to treat schizophrenia, and .beta.-lactam antibiotics alone to treat schizophrenia.
Abstract translation: 单独或与锌和/或β-内酰胺抗生素一起使用γ-亚麻酸和相关材料来治疗精神分裂症,单独使用β-内酰胺类抗生素治疗精神分裂症。
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公开(公告)号:US06441038B1
公开(公告)日:2002-08-27
申请号:US09686629
申请日:2000-10-12
Applicant: Cari Loder , David F. Horrobin
Inventor: Cari Loder , David F. Horrobin
IPC: A61K31195
CPC classification number: A61K31/55 , A61K45/06 , A61K2300/00
Abstract: A method of treatment of disorders of neurological origin and drug formulations for use in the method are disclosed. These conditions comprise fatigue and associated syndromes of pain, weakness and depressed mood which are associated with chronic fatigue syndrome, brain injury and stroke, stress, fibromyalgia, and irritable bowel syndrome. The treatment comprises administering to a patient in need thereof a selective inhibitor of noradrenaline reuptake combined with either phenylalanine or tyrosine in the same dosage form or the same pack.# The noradrenergic drug may be selected from lofepramine, desipramine or reboxetine. The selective inhibitor may be a combined inhibitor of both noradrenaline and serotonin reuptake such as venlafaxine, duloxetine or milnacipran, or an inhibitor of both noradrenaline and dopamine reuptake such as bupropion.
Abstract translation: 公开了一种治疗神经源性疾病的方法和用于该方法的药物制剂。 这些病症包括与慢性疲劳综合征,脑损伤和中风,压力,纤维肌痛和肠易激综合征相关的疲劳和相关的疼痛,虚弱和抑郁情绪综合征。 该治疗包括向有需要的患者施用去甲肾上腺素再摄取的选择性抑制剂与相同剂型或相同包装中的苯丙氨酸或酪氨酸组合。#去甲肾上腺素能药可以选自洛哌匹灵,地昔帕明或瑞波西汀。 选择性抑制剂可以是去甲肾上腺素和5-羟色胺再摄取的组合抑制剂,如文拉法辛,度洛西汀或米那普仑,或去甲肾上腺素和多巴胺再摄入如安非他酮的抑制剂。
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公开(公告)号:US5888541A
公开(公告)日:1999-03-30
申请号:US784105
申请日:1997-01-15
Applicant: David F. Horrobin , Brenda E. Reynolds
Inventor: David F. Horrobin , Brenda E. Reynolds
IPC: A61K31/201 , A61K35/78 , A61K9/20
CPC classification number: A61K31/201
Abstract: Increase gut calcium absorption in humans or animals by the administration of GLA, DGLA or LA as such or in salt or other pharmacologically acceptable form, optionally in association with EPA, DHA or other EFA in similar forms, specifically useful in the treatment of osteoporosis.
Abstract translation: 通过施用GLA,DGLA或LA本身或以盐或其他药理学上可接受的形式,任选地与EPA,DHA或其他类似形式的EFA相关联地增加对人或动物的肠吸收钙吸收,特别可用于治疗骨质疏松症。
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公开(公告)号:US5866703A
公开(公告)日:1999-02-02
申请号:US543799
申请日:1995-10-16
Applicant: David F. Horrobin , Austin McMordie , Mehar Singh Manku , Philip Knowles
Inventor: David F. Horrobin , Austin McMordie , Mehar Singh Manku , Philip Knowles
IPC: A23D9/00 , A23L1/30 , A61K8/11 , A61K8/30 , A61K8/37 , A61K31/23 , A61K31/232 , A61P17/00 , A61P25/28 , A61P29/00 , A61P37/08 , C07C69/52 , C07C69/587 , C11C3/00 , C07C57/00
CPC classification number: A61K31/232 , A23L33/12 , A61K31/23 , C07C69/52 , C07C69/587
Abstract: Triglycerides with at least two different acids chosen from 6-desaturated essential fatty acids and oleic acid, useful in nutrition and in medicine.
Abstract translation: 具有至少两种选自6-去饱和必需脂肪酸和油酸的不同酸的甘油三酸酯,可用于营养和医学。
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公开(公告)号:US5620701A
公开(公告)日:1997-04-15
申请号:US600005
申请日:1996-02-14
Applicant: David F. Horrobin , Yung-Sheng Huang
Inventor: David F. Horrobin , Yung-Sheng Huang
IPC: A61K31/23 , A23D9/00 , A23L1/30 , A61K8/00 , A61K8/30 , A61K8/37 , A61K8/96 , A61P13/02 , A61P15/00 , A61P17/00 , A61P25/04 , A61Q5/00 , A61Q19/00 , C07C69/587 , C11B3/10 , C11B7/00 , C11D3/06 , A61K9/70 , A61K9/14 , A61K31/20 , A61K47/12
CPC classification number: A23D9/00 , A61K31/23 , C07C69/587
Abstract: Atopic eczema, breast pain or premenstrual syndrome are treated by administering to a person in need of same a composition containing at least 20% di-linoleoyl-mono-gamma-linolenyl glycerol by weight.
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公开(公告)号:US5264217A
公开(公告)日:1993-11-23
申请号:US959472
申请日:1992-10-09
Applicant: David F. Horrobin
Inventor: David F. Horrobin
IPC: A61K31/20
CPC classification number: A61K31/20 , Y10S514/922
Abstract: Methods for increasing the total fat and therefore energy content of mammalian and particularly human milk, the essential fatty acid content of that milk and the flow of that milk during lactation, or for preventing or reducing the normal decrease in milk fat content that occurs during prolonged lactation, by administering gamma linolenic acid, dihomo-gamma-linolenic acid or their mixture, alone or a physiologically acceptable diluent or carrier, in a form administrable to the lactating female.
Abstract translation: 增加哺乳动物和特别是人乳的总脂肪,因此能量含量的方法,该乳的必需脂肪酸含量和哺乳期间该奶的流动,或用于预防或减少在长时间内发生的乳脂含量的正常降低 通过以可施用于哺乳期雌性的形式单独或单独或生理上可接受的稀释剂或载体施用γ-亚麻酸,二亚非 - γ-亚麻酸或其混合物。
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公开(公告)号:US5262174A
公开(公告)日:1993-11-16
申请号:US732492
申请日:1991-07-18
Applicant: David F. Horrobin
Inventor: David F. Horrobin
IPC: A61K31/19 , A61K31/505 , A61K33/14 , A61K38/21 , A61K31/70
CPC classification number: A61K31/70 , A61K31/19 , A61K31/505 , A61K33/14 , A61K38/21
Abstract: The treatment of viral infections with a lithium salt and one of cytarabine or idoxuridine.
Abstract translation: 用盐酸盐治疗病毒感染,阿糖尿病或阿托脲治疗。
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