公开(公告)号：US10214594B2

公开(公告)日：2019-02-26

申请号：US15550097

申请日：2016-03-08

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Knarr ,  Robert B. Appell

IPC: A61K9/48 ,  A61K47/38 ,  C08B11/20 ,  C08B13/00 ,  A23L33/125

Abstract: An esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent hydrocarbon group, has the following properties: i) the degree of neutralization of the groups —C(O)—R—COOH is not more than 0.4, ii) the total degree of ester substitution is from 0.10 to 0.70, and iii) the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 2 C.

公开(公告)号：US20180134812A1

公开(公告)日：2018-05-17

申请号：US15574497

申请日：2016-05-26

Applicant: Dow Global Technologies LLC

Inventor： Roland Adden ,  Tirtha Chatterjee ,  Matthias Knarr ,  Meinolf Brackhagen

IPC: C08B11/20 ,  B01J2/04

CPC classification number: C08B11/20 ,  B01J2/04 ,  C08B11/02 ,  C08J3/122 ,  C08J3/14 ,  C08J2301/26

Abstract: Provided is a method of making methylcellulose-type ether in powder form, said method comprising (a) providing a solution of said methylcellulose-type ether in water, and (b) then separating said methylcellulose-type ether from said water to produce dried methylcellulose-type ether, with the proviso that either (i) step (b) produces said methylcellulose-type ether in powder form, or (ii) after step (b), said method additionally comprises a step (c) of subjecting said dried methylcellulose-type ether to mechanical stress to produce said methylcellulose-type ether in powder form.

公开(公告)号：US20180072820A1

公开(公告)日：2018-03-15

申请号：US15550109

申请日：2016-03-08

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Knarr

IPC: C08B13/00 ,  A61K47/38 ,  A61K9/48 ,  A61K9/10 ,  A23L33/125 ,  A23P10/30

Abstract: An esterified cellulose comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent hydrocarbon group, has the following properties: i) the degree of neutralization of the groups —C(O)—R—COOH is not more than 0.4, ii) the total degree of ester substitution is from 0.03 to 0.38, and iii) the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 20° C.

公开(公告)号：US20180072819A1

公开(公告)日：2018-03-15

申请号：US15550097

申请日：2016-03-08

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Knarr ,  Robert B. Appell

IPC: C08B13/00 ,  A61K9/48 ,  A23L33/125

CPC classification number: C08B13/00 ,  A23L33/125 ,  A23V2002/00 ,  A61K9/4816 ,  A61K9/4866 ,  A61K47/38 ,  C08B11/20

Abstract: An esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent hydrocarbon group, has the following properties: i) the degree of neutralization of the groups —C(O)—R—COOH is not more than 0.4, ii) the total degree of ester substitution is from 0.10 to 0.70, and iii) the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 2 C.

公开(公告)号：US20180030157A1

公开(公告)日：2018-02-01

申请号：US15549858

申请日：2016-03-08

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Knarr ,  Meinolf Brackhagen ,  Matthias Sprehe

IPC: C08B11/20 ,  C08B13/00 ,  C08L1/26

CPC classification number: C08B11/20 ,  A61K9/146 ,  C08B13/00 ,  C08L1/26

Abstract: A process for fractionating an esterified cellulose ether comprising groups of the formula —C(O)—R—COOH, wherein R is a divalent hydrocarbon group, comprises the steps of a) blending the esterified cellulose ether comprising groups of the formula —C(O)—R—COOH with an aqueous liquid and setting the temperature of the resulting blend to less than 10° C. to dissolve a portion of the esterified cellulose ether in the aqueous liquid, b) separating the non-dissolved portion of the esterified cellulose ether from the remainder of the blend, and c) recovering or disposing of the esterified cellulose ether that is dissolved in the aqueous liquid.

公开(公告)号：US20170240654A1

公开(公告)日：2017-08-24

申请号：US15503600

申请日：2015-08-18

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Knarr ,  Matthias Sprehe

IPC: C08B13/00 ,  C09D101/32 ,  A61K9/48

CPC classification number: C08B13/00 ,  A61K9/146 ,  A61K9/2054 ,  A61K9/4816 ,  A61K47/38 ,  C08L1/32 ,  C09D101/32

Abstract: Esterified cellulose ethers which have i) as ester groups aliphatic monovalent acyl groups or groups of the formula —C(O)—R—COOA or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and ii) a content of not more than 0.85 weight percent acetone-insoluble esterified cellulose ether particles, when the esterified cellulose ether is present in a mixture of 12.5 weight parts of esterified cellulose ether and 87.5 weight parts of acetone at 21° C., the weight percent acetone-insoluble esterified cellulose ether particles being based on the total weight of the esterified cellulose ether, wherein iii) not more than 14 percent of the acetone-insoluble esterified cellulose ether particles have a particle size of more than 90 micrometers.

公开(公告)号：US20170173159A1

公开(公告)日：2017-06-22

申请号：US15129505

申请日：2015-03-03

Applicant: Dow Global Technologies LLC

Inventor： Neal J. Fetner ,  David L. Malotky ,  Jin Zhao ,  Matthias Knarr ,  Michael J. Devon ,  Roland Adden

IPC: A61K47/38 ,  A61J3/07 ,  A61K9/48 ,  A61K9/28 ,  C08L1/32 ,  C08B13/00

CPC classification number: A61K47/38 ,  A61J3/07 ,  A61K9/2866 ,  A61K9/4816 ,  C08B13/00 ,  C08L1/32

Abstract: An aqueous composition useful for producing capsules shells comprises a) at least one dispersed esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and b) from 0.05 to 20 percent of at least one salt of a fatty acid, based on the weight of the dispersed esterified cellulose ether, wherein the median particle size, d50, of the dispersed esterified cellulose ether particles is up to 7 micrometers, such median particle size (d50) being the size at which 50 mass percent of the particles have a smaller equivalent diameter and 50 mass percent have a larger equivalent diameter.

公开(公告)号：US20160235682A1

公开(公告)日：2016-08-18

申请号：US15023856

申请日：2014-09-15

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Meinolf Brackhagen ,  Matthias Knarr ,  Roland Adden

IPC: A61K9/48 ,  A61K9/10 ,  A61K47/38

CPC classification number: A61K9/4866 ,  A61K9/08 ,  A61K9/10 ,  A61K9/4808 ,  A61K9/4816 ,  A61K9/4891 ,  A61K47/10 ,  A61K47/38 ,  C08L1/284

Abstract: A liquid composition which comprises an organic liquid diluent and a hydroxyalkyl methylcellulose which has a certain distribution of substituted hydroxyalkoxyl groups and unsubstituted hydroxyalkoxyl groups is stable over an extended time period. In the hydroxyalkyl methylcellulose hydroxyalkoxyl groups are classified into a fraction (A) and a fraction (B), wherein fraction (A) represents the sum of all molar fractions of substituted hydroxyalkoxyl groups having hydroxyl groups substituted further with methoxyl groups and fraction (B) represents the sum of all molar fractions of unsubstituted hydroxyalkoxyl groups having hydroxyl groups not substituted further with methoxyl groups and wherein the ratio fraction (A)/fraction (B) is at least 0.30. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one hydroxypropyl methylcellulose by spray-drying.

Abstract translation: 包含有机液体稀释剂和羟烷基甲基纤维素的液体组合物，其具有取代的羟基烷氧基和未取代的羟基烷氧基的一定分布在延长的时间段内是稳定的。 在羟烷基甲基纤维素中，羟基烷氧基分为级分（A）和级分（B），其中级分（A）代表具有被甲氧基进一步取代的羟基的取代的羟基烷氧基的所有摩尔分数和级分（B） 表示具有未被甲氧基进一步取代的羟基的未取代的羟基烷氧基的所有摩尔分数的总和，并且其中所述比例分数（A）/分数（B）为至少0.30。 液体组合物可用于通过喷雾干燥制备包含至少一种羟丙基甲基纤维素中的至少一种活性成分的固体分散体。

公开(公告)号：US20160114047A1

公开(公告)日：2016-04-28

申请号：US14890617

申请日：2014-07-16

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Jaime Curtis-Fisk ,  Susan L. Jordan ,  True L. Rogers ,  Matthias Knarr ,  Meinolf Brackhagen ,  Roland Adden

IPC: A61K47/38 ,  A61K47/02 ,  A61K31/167 ,  A61K9/00

CPC classification number: A61K47/38 ,  A61K9/0043 ,  A61K31/167 ,  A61K47/02

Abstract: A composition designed for application to a mucosa comprises a tonicity-adjusting agent, a methylcellulose, and a liquid diluent, wherein the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups.

Abstract translation: 设计用于粘膜的组合物包括张力调节剂，甲基纤维素和液体稀释剂，其中甲基纤维素具有通过1-4键连接的脱水葡萄糖单元，其中脱水葡萄糖单元的羟基被甲基取代，使得s23 / s26为0.36以下，其中s23是脱水葡萄糖单元的摩尔分数，其中脱水葡萄糖单元的2-和3-位中的两个羟基仅被甲基取代，并且其中s26是脱水葡萄糖单元的摩尔分数，其中仅 脱水葡萄糖单元的2-和6-位上的两个羟基被甲基取代。