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31.发明申请Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins 审中-公开使用非抗菌四环素类似物及其制剂用于治疗细菌外毒素公开(公告)号：US20080233151A1
公开(公告)日：2008-09-25
申请号：US11890546
申请日：2007-08-06
申请人： Lorne M. Golub , Stephen G. Walker
发明人： Lorne M. Golub , Stephen G. Walker
CPC分类号： A61K45/06 , A61K31/165 , A61K31/65 , A61K39/02 , A61K2300/00
摘要： The invention relates to methods for protecting and/or treating a mammal at risk of acquiring a condition associated with bacteria that produce a calmodulin exotoxin, a metalloproteinase exotoxin, or both, by administering a non-antibacterial tetracycline formulation.
摘要翻译： 本发明涉及通过施用非抗菌四环素制剂来保护和/或治疗有风险获得与产生钙调素外毒素，金属蛋白酶外毒素或两者的细菌相关的病症的哺乳动物的方法。
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公开(公告)号：US06914057B1
公开(公告)日：2005-07-05
申请号：US09787866
申请日：1999-09-28
IPC分类号： A61K31/65
CPC分类号： A61K31/65
摘要： Methods of reducing the risk of cataract development in a mammal are provided and include administering to the mammal an effective amount of a tetracycline derivative. A preferred tetracycline derivative administered according to the methods of the present invention is 6α-deoxy 5-hydroxy-4-dedimethylaminotetracycline.
摘要翻译： 提供降低哺乳动物白内障发展风险的方法，包括向哺乳动物施用有效量的四环素衍生物。 根据本发明方法施用的优选的四环素衍生物是6α-脱氧-5-羟基-4-脱二甲基氨基四环素。
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公开(公告)号：US06280687B1
公开(公告)日：2001-08-28
申请号：US09642380
申请日：2000-08-21
IPC分类号： G01N2100
CPC分类号： G01N33/573 , G01N2333/96486 , Y10S435/975
摘要： The invention relates to methods and test kits for diagnosis of periodontal disease activity in mammals, especially in human. The methods of the invention provide for rapid chair-side diagnosis of periodontitis, peri-implantitis and HIV (+)-infection/AIDS-disease related periodontal diseases. Especially, the methods of the invention provide for rapid chair-side diagnosis of the loss of bone density associated with periodontal diseases.
摘要翻译： 本发明涉及用于诊断哺乳动物，特别是人类中牙周病活动的方法和测试试剂盒。 本发明的方法提供牙周炎，植入周围炎和HIV（+） - 感染/ AIDS相关牙周病的快速椅子诊断。 特别地，本发明的方法提供了与牙周疾病相关的骨密度损失的快速的椅子侧诊断。
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公开(公告)号：US5998390A
公开(公告)日：1999-12-07
申请号：US161804
申请日：1998-09-28
IPC分类号： C12N9/64 , A61K31/65 , A61K31/66 , A61K31/663 , A61P1/02 , A61P1/04 , A61P9/00 , A61P11/00 , A61P11/06 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P31/18 , A61P35/00 , C12N9/99 , A01N52/00
CPC分类号： A61K31/66 , Y10S514/825 , Y10S514/826 , Y10S514/866 , Y10S514/90 , Y10S514/902 , Y10S514/903 , Y10S514/912 , Y10S514/914 , Y10S514/925
摘要： Tissue-destructive conditions related to excess proteinase activity in a biological system are treated or prevented by administering to the system a composition which combines a tetracycline and a bisphosphonate in synergistic proteinase inhibiting amounts.
摘要翻译： 通过向系统施用组合四环素和双膦酸盐的协同蛋白酶抑制量的组合物来治疗或预防与生物系统中过量蛋白酶活性相关的组织破坏性条件。
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35.发明授权Method for inhibiting expression of inducible nitric oxide synthase with tetracycline 失效用四环素抑制诱导型一氧化氮合酶表达的方法
公开(公告)号：US5919775A
公开(公告)日：1999-07-06
申请号：US61286
申请日：1998-04-16
申请人： Ashok R. Amin , Steven B. Abramson , Lorne M. Golub , Nungavaram S. Ramamurthy , Thomas F. McNamara , Robert A. Greenwald , Howard Trachtman
发明人： Ashok R. Amin , Steven B. Abramson , Lorne M. Golub , Nungavaram S. Ramamurthy , Thomas F. McNamara , Robert A. Greenwald , Howard Trachtman
CPC分类号： A61K31/65
摘要： The invention is a method of inhibiting the production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo biological system. The method employs a tetracycline compound to inhibit the production of NO and/or to inhibit the expression or activity of an inducible isoform of nitric oxide synthase (iNOS). Preferably, the tetracycline compound has inhibitory activity for metalloproteinases. Also it is preferred that the tetracycline compound is provided to the biological system in an amount which has little or no antibacterial activity in the system. Accordingly, preferred tetracycline compounds are tetracycline compounds which have be modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions.
摘要翻译： 本发明是一种在体内，体外或离体生物体系中抑制一氧化氮（NO）的产生的方法。 该方法采用四环素化合物抑制NO的产生和/或抑制一氧化氮合酶（iNOS）的诱导型异构体的表达或活性。 优选地，四环素化合物对金属蛋白酶具有抑制活性。 此外，优选的是，四环素化合物以系统中几乎没有或没有抗菌活性的量提供给生物系统。 因此，优选的四环素化合物是四环素化合物，其被修饰以降低或消除其抗微生物活性。 该方法可用于治疗以iNOS介导的NO产生为特征的哺乳动物的医疗状况，包括例如炎性病症。
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36.发明授权Method of using tetracycline compounds for inhibition of endogenous nitric oxide production 失效使用四环素化合物抑制内源性一氧化氮产生的方法
公开(公告)号：US5789395A
公开(公告)日：1998-08-04
申请号：US697815
申请日：1996-08-30
申请人： Ashok R. Amin , Steven B. Abramson , Lorne M. Golub , Nungavaram S. Ramamurthy , Thomas F. McNamara , Robert A. Greenwald , Howard Trachtman
发明人： Ashok R. Amin , Steven B. Abramson , Lorne M. Golub , Nungavaram S. Ramamurthy , Thomas F. McNamara , Robert A. Greenwald , Howard Trachtman
CPC分类号： A61K31/65
摘要： A method is disclosed for inhibiting endogenous production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo mammalian system. The method employs a tetracycline compound to inhibit production of NO and/or to inhibit the expression or activity of an inducible isoform of nitric oxide synthase (iNOS). Preferably, the tetracycline compound has inhibitory activity for metalloproteinases. Also it is preferred that the tetracycline compound is provided to the mammalian system in an amount which has little or no antibacterial activity in the system. Accordingly, preferred tetracycline compounds are tetracycline compounds which have be modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions.
摘要翻译： 公开了用于抑制体内，体外或离体哺乳动物系统中一氧化氮（NO）的内源性产生的方法。 该方法采用四环素化合物抑制NO的产生和/或抑制一氧化氮合酶（iNOS）的诱导型亚型的表达或活性。 优选地，四环素化合物对金属蛋白酶具有抑制活性。 此外，优选的是，四系环化合物以系统中几乎没有或没有抗菌活性的量提供给哺乳动物系统。 因此，优选的四环素化合物是四环素化合物，其被修饰以降低或消除其抗微生物活性。 该方法可用于治疗以iNOS介导的NO产生为特征的哺乳动物的医疗状况，包括例如炎性病症。
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37.发明授权Tetracyclines including non-antimicrobial chemically-modified tetracyclines inhibit excessive glycosylation of different types of collagen and other proteins during diabetes 失效四环素包括非抗微生物化学修饰的四环素抑制糖尿病期间不同类型胶原蛋白和其他蛋白质的过度糖基化
公开(公告)号：US5532227A
公开(公告)日：1996-07-02
申请号：US361116
申请日：1994-12-21
CPC分类号： A61K31/65 , Y10S514/866 , Y10S514/912
摘要： A method for treating mammals suffering from excessive extracellular protein glycosylation which is associated with diabetes, scleroderma and progeria by administering to the mammal a tetracycline which effectively inhibits excessive protein glycosylation.
摘要翻译： 通过向哺乳动物施用有效抑制过量蛋白质糖基化的四环素来治疗患有与糖尿病，硬皮病和原发性相关的过度细胞外蛋白质糖基化的哺乳动物的方法。
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38.发明授权Composition comprising indomethacin [non-steroidal anti-inflammatory agent] and effectively non-antibacterial tetracycline to reduce bone loss 失效包含吲哚美辛[非甾体抗炎剂]和有效的非抗菌四环素以减少骨丢失的组合物
公开(公告)号：US5459135A
公开(公告)日：1995-10-17
申请号：US200415
申请日：1994-02-23
IPC分类号： A61K31/19 , A61K31/215 , A61K31/54 , A61K31/60 , A61K31/65 , A61K45/06 , A61P1/02 , A61P3/00 , A61P17/00 , A61P19/10 , A61P27/02 , A61P29/00 , A61P43/00 , A61K31/40
CPC分类号： A61K31/65 , Y10S514/825
摘要： A method for treating mammals suffering from rheumatoid arthritis and other tissue-destructive (chronic inflammatory or other) conditions associated with excess metalloproteinase activity comprising administering to the mammal an amount of a tetracycline that is effectively anti-metalloproteinase, but that is not effectively antimicrobial, and an amount of non-steroidal anti-inflammatory agent which, when combined with the effectively anti-metalloproteinase amount of tetracycline, results in a significant reduction of tissue destruction and/or bone loss.
摘要翻译： 用于治疗患有类风湿性关节炎和与过量金属蛋白酶活性相关的其它组织破坏性（慢性炎症或其他）病症的哺乳动物的方法，包括向哺乳动物施用一定量的有效抗金属蛋白酶的四环素，但不能有效地抗微生物， 和一定量的非甾体抗炎剂，当与有效的抗金属蛋白酶量的四环素组合时，导致组织破坏和/或骨丢失的显着减少。
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39.再颁专利Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency 失效使用四环素来增强骨骼蛋白的合成和/或治疗骨缺损
公开(公告)号：USRE34656E
公开(公告)日：1994-07-05
申请号：US878172
申请日：1992-05-04
IPC分类号： A61K31/65
CPC分类号： A61K31/65
摘要： Tetracyclines, antibacterial and non-antibacterial tetracyclines, have been found to be useful in the treatment of osteoporosis in humans by administering to the human suffering from osteoporosis an effective amount of a tetracycline to enhance bone protein synthesis. Tetracyclines which have been found to be effective in the treatment of osteoporosis in humans include minocycline, doxycycline and dedimethylaminotetracyline.
摘要翻译： 已经发现四环素类抗生素和非抗菌四环素通过对患有骨质疏松症的人施用有效量的四环素来增强骨蛋白质合成，可用于治疗人类的骨质疏松症。 已发现在人类骨质疏松症治疗中有效的四环素包括米诺环素，多西环素和去二甲基氨基四环素。
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公开(公告)号：US5258371A
公开(公告)日：1993-11-02
申请号：US891554
申请日：1992-05-29
申请人： Lorne M. Golub , Nangavarum S. Ramamurthy , Thomas F. McNamara , Robert A. Greenwald , Tsutomu Kawai , Takashi Hamasaki , Michiya Shimamura , Goro Kobayashi , Tetsuo Takigawa , Hisashi Iwata
发明人： Lorne M. Golub , Nangavarum S. Ramamurthy , Thomas F. McNamara , Robert A. Greenwald , Tsutomu Kawai , Takashi Hamasaki , Michiya Shimamura , Goro Kobayashi , Tetsuo Takigawa , Hisashi Iwata
IPC分类号： A61K31/65 , A61P19/02 , A61P29/00 , A61P43/00 , C07C235/40 , C07C237/26
CPC分类号： A61K31/65 , Y10S514/825
摘要： Provided is a method of treating humans or animals suffering from a condition or disease characterized by excessive collagen destruction, which comprises administering to said human or animal an effective amount of a 12a-deoxytetracycline represented by the following general formula ##STR1## The method is effective in the treatment of various articular diseases characterized by excessive collagen destruction.
摘要翻译： 本发明提供一种治疗患有特征在于过度胶原破坏的病症或疾病的人或动物的方法，其包括向所述人或动物施用有效量的由以下通式表示的12a-脱氧四环素：该方法是有效的 用于治疗以胶原蛋白破坏过多为特征的各种关节疾病。
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