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10 条记录 (耗时 0.049 秒)

    Method for inhibiting expression of inducible nitric oxide synthase with tetracycline
    8.
    发明授权
    Method for inhibiting expression of inducible nitric oxide synthase with tetracycline 失效
    用四环素抑制诱导型一氧化氮合酶表达的方法

    公开(公告)号：US5919775A

    公开(公告)日：1999-07-06

    申请号：US61286

    申请日：1998-04-16

    申请人： Ashok R. Amin ,  Steven B. Abramson ,  Lorne M. Golub ,  Nungavaram S. Ramamurthy ,  Thomas F. McNamara ,  Robert A. Greenwald ,  Howard Trachtman

    发明人： Ashok R. Amin ,  Steven B. Abramson ,  Lorne M. Golub ,  Nungavaram S. Ramamurthy ,  Thomas F. McNamara ,  Robert A. Greenwald ,  Howard Trachtman

    IPC分类号： A61K31/65 ,  A61P13/12 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00

    CPC分类号： A61K31/65

    摘要： The invention is a method of inhibiting the production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo biological system. The method employs a tetracycline compound to inhibit the production of NO and/or to inhibit the expression or activity of an inducible isoform of nitric oxide synthase (iNOS). Preferably, the tetracycline compound has inhibitory activity for metalloproteinases. Also it is preferred that the tetracycline compound is provided to the biological system in an amount which has little or no antibacterial activity in the system. Accordingly, preferred tetracycline compounds are tetracycline compounds which have be modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions.

    摘要翻译： 本发明是一种在体内，体外或离体生物体系中抑制一氧化氮（NO）的产生的方法。 该方法采用四环素化合物抑制NO的产生和/或抑制一氧化氮合酶（iNOS）的诱导型异构体的表达或活性。 优选地，四环素化合物对金属蛋白酶具有抑制活性。 此外，优选的是，四环素化合物以系统中几乎没有或没有抗菌活性的量提供给生物系统。 因此，优选的四环素化合物是四环素化合物，其被修饰以降低或消除其抗微生物活性。 该方法可用于治疗以iNOS介导的NO产生为特征的哺乳动物的医疗状况，包括例如炎性病症。

    Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
    9.
    发明授权
    Method of using tetracycline compounds for inhibition of endogenous nitric oxide production 失效
    使用四环素化合物抑制内源性一氧化氮产生的方法

    公开(公告)号：US5789395A

    公开(公告)日：1998-08-04

    申请号：US697815

    申请日：1996-08-30

    申请人： Ashok R. Amin ,  Steven B. Abramson ,  Lorne M. Golub ,  Nungavaram S. Ramamurthy ,  Thomas F. McNamara ,  Robert A. Greenwald ,  Howard Trachtman

    发明人： Ashok R. Amin ,  Steven B. Abramson ,  Lorne M. Golub ,  Nungavaram S. Ramamurthy ,  Thomas F. McNamara ,  Robert A. Greenwald ,  Howard Trachtman

    IPC分类号： A61K31/65 ,  A61P13/12 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00 ,  C12N9/99 ,  C12N9/04 ,  C12N9/06

    CPC分类号： A61K31/65

    摘要： A method is disclosed for inhibiting endogenous production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo mammalian system. The method employs a tetracycline compound to inhibit production of NO and/or to inhibit the expression or activity of an inducible isoform of nitric oxide synthase (iNOS). Preferably, the tetracycline compound has inhibitory activity for metalloproteinases. Also it is preferred that the tetracycline compound is provided to the mammalian system in an amount which has little or no antibacterial activity in the system. Accordingly, preferred tetracycline compounds are tetracycline compounds which have be modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions.

    摘要翻译： 公开了用于抑制体内，体外或离体哺乳动物系统中一氧化氮（NO）的内源性产生的方法。 该方法采用四环素化合物抑制NO的产生和/或抑制一氧化氮合酶（iNOS）的诱导型亚型的表达或活性。 优选地，四环素化合物对金属蛋白酶具有抑制活性。 此外，优选的是，四系环化合物以系统中几乎没有或没有抗菌活性的量提供给哺乳动物系统。 因此，优选的四环素化合物是四环素化合物，其被修饰以降低或消除其抗微生物活性。 该方法可用于治疗以iNOS介导的NO产生为特征的哺乳动物的医疗状况，包括例如炎性病症。