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254 条记录 (耗时 0.053 秒)

    3,6-bicyclolides
    31.
    发明申请
    3,6-bicyclolides 有权
    3,6-双环氯化物

    公开(公告)号：US20060142214A1

    公开(公告)日：2006-06-29

    申请号：US11295736

    申请日：2005-12-06

    申请人： Yat Or ,  Datong Tang ,  Ying Sun ,  Yonghua Gai ,  Guoyou Xu ,  Zhe Wang

    发明人： Yat Or ,  Datong Tang ,  Ying Sun ,  Yonghua Gai ,  Guoyou Xu ,  Zhe Wang

    IPC分类号： C07H17/08 ,  A61K31/7052

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了具有抗菌性质的式（I）化合物或其药学上可接受的盐，酯或前药。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    Macrocyclic oximyl hepatitis C serine protease inhibitors
    33.
    发明授权
    Macrocyclic oximyl hepatitis C serine protease inhibitors 有权
    大环肟基丙型肝炎丝氨酸蛋白酶抑制剂

    公开(公告)号：US08222203B2

    公开(公告)日：2012-07-17

    申请号：US12333457

    申请日：2008-12-12

    申请人： Ying Sun ,  Yonghua Gai ,  Yat Sun Or ,  Zhe Wang

    发明人： Ying Sun ,  Yonghua Gai ,  Yat Sun Or ,  Zhe Wang

    IPC分类号： A61K38/00

    CPC分类号： C07K5/0812 ,  A61K38/00 ,  C07K5/06165

    摘要： The present invention relates to compounds of Formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising a compound of the present invention.

    摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，酯或前体药物：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

    MACROCYCLIC OXIMYL HEPATITIS C SERINE PROTEASE INHIBITORS
    34.
    发明申请
    MACROCYCLIC OXIMYL HEPATITIS C SERINE PROTEASE INHIBITORS 有权
    大环氧合酶抑制剂C丝氨酸蛋白酶抑制剂

    公开(公告)号：US20090180984A1

    公开(公告)日：2009-07-16

    申请号：US12333457

    申请日：2008-12-12

    申请人： Ying Sun ,  Yonghua Gai ,  Yat Sun Or ,  Zhe Wang

    发明人： Ying Sun ,  Yonghua Gai ,  Yat Sun Or ,  Zhe Wang

    IPC分类号： A61K38/21 ,  C07D225/04 ,  A61K31/40 ,  A61K31/708 ,  A61P35/00

    CPC分类号： C07K5/0812 ,  A61K38/00 ,  C07K5/06165

    摘要： The present invention relates to compounds of Formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising a compound of the present invention.

    摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，酯或前体药物：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

    OXIMYL HYDROXYAMIC ANALOGS AS HEPATITIS C VIRUS PROTEASE INHIBITOR
    35.
    发明申请
    OXIMYL HYDROXYAMIC ANALOGS AS HEPATITIS C VIRUS PROTEASE INHIBITOR 审中-公开
    OXIMYL羟肟酸类似物作为丙型肝炎病毒蛋白酶抑制剂

    公开(公告)号：US20080274082A1

    公开(公告)日：2008-11-06

    申请号：US12108653

    申请日：2008-04-24

    申请人： Yonghua Gai ,  Ying Sun ,  Yat Sun Or ,  Zhe Wang

    发明人： Yonghua Gai ,  Ying Sun ,  Yat Sun Or ,  Zhe Wang

    IPC分类号： A61K38/05 ,  C07D207/02 ,  C07D401/12 ,  A61K38/21 ,  A61P31/12 ,  C07D405/12 ,  C07D409/12

    CPC分类号： A61K31/7056 ,  A61K31/01 ,  A61K38/212 ,  A61K38/215 ,  A61K45/06 ,  C07K5/0808 ,  C07K5/0812 ,  A61K2300/00

    摘要： The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

    摘要翻译： 本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶活性的式I化合物或其药学上可接受的盐，酯或前药。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

    Triazolyl macrocyclic hepatitis C serine protease inhibitors
    36.
    发明授权
    Triazolyl macrocyclic hepatitis C serine protease inhibitors 失效
    三唑基大环丙型肝炎丝氨酸蛋白酶抑制剂

    公开(公告)号：US07662779B2

    公开(公告)日：2010-02-16

    申请号：US11835657

    申请日：2007-08-08

    申请人： Ying Sun ,  Deqiang Niu ,  Yat Sun Or ,  Zhe Wang

    发明人： Ying Sun ,  Deqiang Niu ,  Yat Sun Or ,  Zhe Wang

    IPC分类号： A61K38/12 ,  C07K5/12

    CPC分类号： C07D487/04 ,  A61K31/4192 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/7056 ,  A61K38/21 ,  C07D471/04 ,  A61K2300/00

    摘要： The present invention relates to compounds of Formula I or II, or pharmaceutically acceptable salts, esters or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering to the subject a pharmaceutical composition comprising a compound of the present invention.

    摘要翻译： 本发明涉及式I或II的化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过向受试者施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

    Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
    37.
    发明授权
    Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors 有权
    喹喔啉基大环丙型肝炎丝氨酸蛋白酶抑制剂

    公开(公告)号：US07368452B2

    公开(公告)日：2008-05-06

    申请号：US11489011

    申请日：2006-07-18

    申请人： Suanne Nakajima ,  Zhenwei Miao ,  Ying Sun ,  Datong Tang ,  Gouyou Xu ,  Brian Porter ,  Yat Sun Or ,  Zhe Wang

    发明人： Suanne Nakajima ,  Zhenwei Miao ,  Ying Sun ,  Datong Tang ,  Gouyou Xu ,  Brian Porter ,  Yat Sun Or ,  Zhe Wang

    IPC分类号： A61P31/12

    CPC分类号： C07K5/0802 ,  A61K38/212 ,  A61K38/215 ,  C07D487/04 ,  C07K5/0804 ,  A61K2300/00

    摘要： The present invention relates to compounds of Formula I or II, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

    摘要翻译： 本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶活性的式I或II化合物或其药学上可接受的盐，酯或前药。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

    Tri-peptide hepatitis C serine protease inhibitors
    38.
    发明授权
    Tri-peptide hepatitis C serine protease inhibitors 有权
    三肽丙型肝炎丝氨酸蛋白酶抑制剂

    公开(公告)号：US07718769B2

    公开(公告)日：2010-05-18

    申请号：US11602586

    申请日：2006-11-20

    申请人： Zhenwei Miao ,  Ying Sun ,  Suanne Nakajima ,  Datong Tang ,  Zhe Wang ,  Yat Sun Or

    发明人： Zhenwei Miao ,  Ying Sun ,  Suanne Nakajima ,  Datong Tang ,  Zhe Wang ,  Yat Sun Or

    IPC分类号： A61K38/00

    CPC分类号： C07K5/0808 ,  A61K38/00

    摘要： The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

    摘要翻译： 本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶活性的式I化合物或其药学上可接受的盐，酯或前药。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

    6-11 Bicyclic erythromycin derivatives
    39.
    发明授权
    6-11 Bicyclic erythromycin derivatives 失效
    6-11双环红霉素衍生物

    公开(公告)号：US07414030B2

    公开(公告)日：2008-08-19

    申请号：US11029640

    申请日：2005-01-05

    申请人： Nha Huu Vo ,  Guoqiang Wang ,  Guoyou Xu ,  Ying Hou ,  Ying Sun ,  Ly Tam Phan ,  Zhe Wang ,  Yat Sun Or

    发明人： Nha Huu Vo ,  Guoqiang Wang ,  Guoyou Xu ,  Ying Hou ,  Ying Sun ,  Ly Tam Phan ,  Zhe Wang ,  Yat Sun Or

    IPC分类号： A61K31/70 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formulaes I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I，II，III或IV的化合物或其外消旋体，对映异构体，区域异构体，盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。