公开(公告)号：US11883294B2

公开(公告)日：2024-01-30

申请号：US17663626

申请日：2022-05-16

Applicant: Edwards Lifesciences Corporation

Inventor： Arie Tylis ,  Nikolai Gurovich ,  Eran Goldberg ,  Boaz Manash ,  Dan Rottenberg ,  Hagar Adika ,  Tal Regev ,  Dikla Kersh ,  Danny M. Garmahi ,  Hernan Altman ,  Amir Blumenfeld

IPC: A61F2/24 ,  A61B17/04 ,  A61B17/00 ,  A61B8/08 ,  A61B8/12 ,  A61B8/00

CPC classification number: A61F2/2487 ,  A61B8/085 ,  A61B8/0883 ,  A61B8/12 ,  A61B8/42 ,  A61B17/0401 ,  A61F2/2445 ,  A61B2017/00243 ,  A61B2017/00783 ,  A61B2017/042 ,  A61B2017/0409 ,  A61B2017/0419 ,  A61B2017/0464 ,  A61F2/2466

Abstract: An anchoring system and related methods are provided for treatment of dilated hearts and of functional valve regurgitation, the system comprising one or more self-expandable or manually expandable anchors and associated devices for fixating a valve splint within the heart. For example, a spade-shaped assembly may be configured to be deployed in a right ventricle of the heart and to stabilize a puncturing instrument to puncture the septum. Various puncturing instruments may also be part of the anchoring system, including one or more of a flexible needle having a multiplicity of slits disposed along the length of the needle, a trocar catheter with a retractable head, and a catheter needle having a blunt introducer to protect nearby tissue within the heart during advancing a guidewire. A cutter catheter and puncture location catheter may also be part of the system and be used during treatment.

公开(公告)号：US20230077068A1

公开(公告)日：2023-03-09

申请号：US17932654

申请日：2022-09-15

Applicant: Edwards Lifesciences Corporation

Inventor： Ilan Tamir ,  David Maimon ,  Hanoch Cohen-Tzemach ,  Adva Alon ,  Amir Keret ,  Eyal Leiba ,  Boaz Manash ,  Sean Chow ,  Ziv Yohanan ,  Shay Zarneger

IPC: A61F2/24 ,  A61B17/3205 ,  A61B18/14 ,  A61B17/32 ,  A61B17/34

Abstract: Methods and tools for implanting prosthetic heart valves and modifying leaflets of an existing valvular structure in a subject are disclosed herein. Prior to or during implantation of the prosthetic heart valve within the existing valvular structure, each tool can be provided in the ascending aorta (or equivalent thereof) of a subject and can be used to pierce, lacerate, slice, tear, cut or otherwise modify a leaflet or commissure of the existing valvular structure. The existing valvular structure can be a native aortic valve or other native heart valve, or a previously-implanted prosthetic heart valve. The modification can avoid, or at least reduce the likelihood of, issues that leaflets of the existing valvular structure might otherwise cause once the prosthetic heart valve has been fully installed, for example, obstruction of blood flow to the coronary arteries and/or improper valve mounting due to a non-circular cross-section.

公开(公告)号：US20220273438A1

公开(公告)日：2022-09-01

申请号：US17663626

申请日：2022-05-16

Applicant: Edwards Lifesciences Corporation

Inventor： Arie Tylis ,  Nikolay Gurovich ,  Eran Goldberg ,  Boaz Manash ,  Dan Rottenberg ,  Hagar Adika ,  Tal Regev ,  Dikla Kersh ,  Danny M. Garmahi ,  Hernan Altman ,  Amir Blumenfeld

IPC: A61F2/24 ,  A61B8/08 ,  A61B17/04 ,  A61B8/12 ,  A61B8/00

Abstract: An anchoring system and related methods are provided for treatment of dilated hearts and of functional valve regurgitation, the system comprising one or more self-expandable or manually expandable anchors and associated devices for fixating a valve splint within the heart. For example, a spade-shaped assembly may be configured to be deployed in a right ventricle of the heart and to stabilize a puncturing instrument to puncture the septum. Various puncturing instruments may also be part of the anchoring system, including one or more of a flexible needle having a multiplicity of slits disposed along the length of the needle, a trocar catheter with a retractable head, and a catheter needle having a blunt introducer to protect nearby tissue within the heart during advancing a guidewire. A cutter catheter and puncture location catheter may also be part of the system and be used during treatment.

公开(公告)号：US20210378818A1

公开(公告)日：2021-12-09

申请号：US17412211

申请日：2021-08-25

Applicant: Edwards Lifesciences Corporation

Inventor： Boaz Manash ,  Noa Axelrod Manela ,  David Linsky

IPC: A61F2/24

Abstract: Devices and methods for repairing a regurgitant heart valve are provided. A blocking component is fastened to a regurgitant valve such that the blocking component situates within the aperture of a regurgitant valve to mitigate the backflow across the valve. A variety of blocking components, fasteners, and delivery systems are described.

公开(公告)号：US20210361417A1

公开(公告)日：2021-11-25

申请号：US17397727

申请日：2021-08-09

Applicant: Edwards Lifesciences Corporation

Inventor： Boaz Manash ,  Khen Perlmutter ,  Adi Carmi ,  Noa Axelrod Manela ,  Nikolay Gurovich

IPC: A61F2/24

Abstract: A method of treating mitral valve stenosis in a human heart includes advancing a delivery apparatus through a right femoral vein, across a septal wall, and through a calcified mitral valve. A prosthetic heart valve is provided along a distal end portion of the delivery apparatus, wherein the prosthetic heart valve includes a metallic frame having a plurality of tissue-engaging elements positioned along an exterior surface and a leaflet structure for replacing the function of the calcified mitral valve. The prosthetic heart valve is radially expanded within an annulus of the calcified mitral valve such that at least some of the tissue-engaging elements of the prosthetic heart valve embed into the annulus. After radial expansion, the prosthetic heart valve is retained in position within the annulus via the tissue-engaging element and the leaflet structure replaces the function of the native mitral valve.

公开(公告)号：US11065111B2

公开(公告)日：2021-07-20

申请号：US15984678

申请日：2018-05-21

Applicant: Edwards Lifesciences Corporation

Inventor： Boaz Manash ,  Yoav Rozen ,  Eitan Atias

IPC: A61F2/24

Abstract: Systems and methods usable in delivering a docking device to a native valve of a patient's heart. A distal region of a delivery catheter can be positioned in an atrium of the heart and a distal tip can be positioned at or near a commissure of the native valve. The docking device can be located within the delivery catheter. A pusher, such as a pusher wire or tube, of a pusher tool can be advanced distally through the delivery catheter, wherein the pusher can push the docking device along within the delivery catheter. The docking device can be connected to the pusher tool by a line, such as a suture. A member of the pusher tool can be rotatable to change the amount of the suture extending from the pusher tool.

公开(公告)号：US20210068957A1

公开(公告)日：2021-03-11

申请号：US17100381

申请日：2020-11-20

Applicant: Edwards Lifesciences Corporation

Inventor： Yaron Keidar ,  Wesley V. Adzich ,  Dan Rottenberg ,  Boaz Manash ,  Alon Nahshon

IPC: A61F2/24

Abstract: An active annuloplasty ring holder having a template that can be folded or pivoted to the side allowing the template to align longitudinally with the handle and enter the patient's chest through a small incision. The holder may include a mechanism to remotely detach sutures fastening the ring to the holder, thereby detaching the ring while avoiding the risk associated with introducing a scalpel into the operating field. A detachment mechanism may include a movable pin actuated by a pull wire that releases a plurality of holding sutures, or a hot wire, knives, or pull wire that severs the sutures. The holder may have a built-in light source for better visualization of the ring inside the heart. The holder may also have an optical means of visualizing the inside of the heart from the proximal end of the handle.

公开(公告)号：US20210007842A1

公开(公告)日：2021-01-14

申请号：US17037451

申请日：2020-09-29

Applicant: Edwards Lifesciences Corporation

Inventor： Boaz Manash ,  Yoav Rozen ,  Eitan Atias

IPC: A61F2/24

Abstract: Systems and methods usable in delivering a docking device to a native valve of a patient's heart. A distal region of a delivery catheter can be positioned in an atrium of the heart and a distal tip can be positioned at or near a commissure of the native valve. The docking device can be located within the delivery catheter. A pusher, such as a pusher wire or tube, of a pusher tool can be advanced distally through the delivery catheter, wherein the pusher can push the docking device along within the delivery catheter. The docking device can be connected to the pusher tool by a line, such as a suture. A member of the pusher tool can be rotatable to change the amount of the suture extending from the pusher tool.

公开(公告)号：US20200306034A1

公开(公告)日：2020-10-01

申请号：US16902612

申请日：2020-06-16

Applicant: Edwards Lifesciences Corporation

Inventor： Darshin S. Patel ,  Hernan Altman ,  Boaz Manash ,  Tamir S. Levi ,  Dinesh L. Sirimanne

IPC: A61F2/24

Abstract: Methods of implanting docking devices for prosthetic valves at a native heart valve include positioning a distal end of a delivery catheter into a first chamber of a heart, advancing a tubular body of a docking device from within the delivery catheter so that the distal end of the tubular body is advanced between native valve leaflets and positioned in a second chamber of the heart. The methods further include inserting a coil into a lumen of the docking device so that the tubular body adopts a configuration, releasing a proximal end of the docking device in the first chamber, inserting a replacement valve in an inner space of the docking device, and radially expanding the replacement valve until there is a retention force between the replacement valve and the docking device to hold the replacement valve in a stable position in the native valve.

公开(公告)号：US10687938B2

公开(公告)日：2020-06-23

申请号：US15684836

申请日：2017-08-23

Applicant: Edwards Lifesciences Corporation

Inventor： Darshin S. Patel ,  Hernan Altman ,  Boaz Manash ,  Tamir S. Levi ,  Dinesh L. Sirimanne

IPC: A61F2/24 ,  A61B17/00 ,  A61B17/064

Abstract: Docking devices can be configured to be positioned at a native valve of a human heart to provide structural support for docking a prosthetic valve. The docking devices generally have coiled structures that define an inner space in which the prosthetic valve can be held. Some docking devices can be adjusted from a first wider configuration which facilitates easier advancement of the docking device around the valve anatomy, to a second narrower configuration after the docking device has been delivered to more securely hold the prosthetic valve. The docking device may also be better held in position at the native valve after adjustment to the narrower configuration. Some docking devices include a stabilization segment or double coil configuration, where a main coil region is configured to securely hold a prosthetic valve, while a stabilization coil region is configured to more stably hold the docking device at the native valve.