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公开(公告)号：US11707280B2
公开(公告)日：2023-07-25
申请号：US17404931
申请日：2021-08-17
IPC分类号： A61B17/10 , A61B17/068 , A61B17/064 , A61B17/122 , A61B17/128
CPC分类号： A61B17/10 , A61B17/064 , A61B17/068 , A61B17/128 , A61B17/1222 , A61B17/105 , A61B2017/0645 , A61B2017/0649
摘要： Devices and methods for deploying self-cinching surgical clips. A device can access at least two layers of tissue or material from only one side of the tissue or material and puncture through the two layers of tissue or material. The various configurations of clips disclosed herein can be made of a superelastic material such as Nitinol, and have a constrained and a relaxed state, and no sharp edges or tips so as to reduce tissue irritation following deployment. The clip can be disposed within the housing of the delivery device and held in a constrained state until deployment wherein the clip assumes its relaxed state, where the ends of the clip can be brought into close approximation, thereby securing the layers of tissue or material together.
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公开(公告)号：US11571299B2
公开(公告)日：2023-02-07
申请号：US16921901
申请日：2020-07-06
发明人： Hengchu Cao , Brian S. Conklin , Paul A. Schmidt , Grace Myong Kim , James A. Davidson , Hoa Trinh Tran , Kristy Luong Tam
IPC分类号： A61F2/24
摘要： Disclosed prosthetic valves can comprise a sewing ring configured to secure the valve to an implantation site. Some disclosed valves comprise a resiliently collapsible frame having a neutral configuration and a collapsed deployment configuration. Some disclosed frames can self-expand to the neutral configuration when released from the collapsed deployment configuration. Collapsing a disclosed valve can provide convenient access to the sewing ring, such as for securing the valve to the implantation site, as well as for the insertion of the valve through relatively small surgical incisions.
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公开(公告)号：US20210369277A1
公开(公告)日：2021-12-02
申请号：US17404931
申请日：2021-08-17
IPC分类号： A61B17/10 , A61B17/068 , A61B17/064 , A61B17/122 , A61B17/128
摘要： Devices and methods for deploying self-cinching surgical clips. A device can access at least two layers of tissue or material from only one side of the tissue or material and puncture through the two layers of tissue or material. The various configurations of clips disclosed herein can be made of a superelastic material such as Nitinol, and have a constrained and a relaxed state, and no sharp edges or tips so as to reduce tissue irritation following deployment. The clip can be disposed within the housing of the delivery device and held in a constrained state until deployment wherein the clip assumes its relaxed state, where the ends of the clip can be brought into close approximation, thereby securing the layers of tissue or material together.
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公开(公告)号：US11090053B2
公开(公告)日：2021-08-17
申请号：US16356604
申请日：2019-03-18
IPC分类号： A61B17/10 , A61B17/068 , A61B17/064 , A61B17/122 , A61B17/128
摘要： Devices and methods for deploying self-cinching surgical clips. A device can access at least two layers of tissue or material from only one side of the tissue or material and puncture through the two layers of tissue or material. The various configurations of clips disclosed herein can be made of a superelastic material such as Nitinol, and have a constrained and a relaxed state, and no sharp edges or tips so as to reduce tissue irritation following deployment. The clip can be disposed within the housing of the delivery device and held in a constrained state until deployment wherein the clip assumes its relaxed state, where the ends of the clip can be brought into close approximation, thereby securing the layers of tissue or material together.
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公开(公告)号：US20200261222A1
公开(公告)日：2020-08-20
申请号：US16861171
申请日：2020-04-28
发明人： Bin Tian , James A. Davidson
摘要： A method of treating a biological tissue that enables dry storage of said tissue is disclosed. In one embodiment, the method comprises contacting the biological tissue with a non-aqueous treatment solution comprising a polyhydric alcohol and a C1-C3 alcohol and removing a portion of the treatment solution from the solution-treated biological tissue. Also disclosed is biological tissue prepared using the above process and prosthetic devices made with such tissue.
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公开(公告)号：US10188511B2
公开(公告)日：2019-01-29
申请号：US15138123
申请日：2016-04-25
摘要： A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to inhibit oxidation in dehydrated tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the oxidation and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. In one method, tissue leaflets in assembled bioprosthetic heart valves are pretreated with an aldehyde capping agent prior to dehydration and sterilization.
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公开(公告)号：US09320830B2
公开(公告)日：2016-04-26
申请号：US14707970
申请日：2015-05-08
CPC分类号： A61F2/2415 , A61F2/0095 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61L27/3604 , A61L27/3625 , A61L27/3629 , A61L27/3687 , A61L27/3691 , A61L27/507 , A61L2400/02 , A61L2430/20
摘要： A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to inhibit oxidation in dehydrated tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the oxidation and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. In one method, tissue leaflets in assembled bioprosthetic heart valves are pretreated with an aldehyde capping agent prior to dehydration and sterilization.
摘要翻译： 用于植入物或组装的生物假体心脏瓣膜中用于减少体内钙化的生物假体组织的治疗。 该方法包括将钙化缓解剂如封端剂或抗氧化剂施用于组织以特异性抑制组织中的氧化。 此外，该方法可用于抑制脱水组织中的氧化。 封端剂抑制由氧化暴露或产生的组织中的结合位点的形成，否则在植入时会吸引钙，磷酸盐，免疫原性因子或钙化的其它前体。 在一种方法中，组装的生物假体心脏瓣膜中的组织小叶在脱水和灭菌之前用醛封端剂预处理。
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38.发明申请公开(公告)号：US20150314042A1
公开(公告)日：2015-11-05
申请号：US14797449
申请日：2015-07-13
CPC分类号： A61L27/3625 , A61F2/2412 , A61F2210/0004 , A61F2210/0076 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/507 , A61L2400/02 , A61L2430/20 , A61L2430/40
摘要： A bioprosthetic tissue having a reduced propensity to calcify in vivo, the bioprosthetic tissue. The bioprosthetic tissue comprises an aldehyde cross-linked and stressed bioprosthetic tissue comprising exposed calcium, phosphate or immunogenic binding sites that have been reacted with a calcification mitigant. The bioprosthetic tissue has a reduced propensity to calcify in vivo as compared to aldehyde cross-linked bioprosthetic tissue that has not been stressed and reacted with the calcification mitigant.
摘要翻译： 生物假体组织具有降低的体内钙化倾向，生物假体组织。 生物假体组织包含醛交联和应激的生物假体组织，其包含与钙化缓解剂反应的暴露的钙，磷酸盐或免疫原性结合位点。 与醛交联的生物假体组织相比，生物假体组织在体内钙化的倾向降低，其未被压力并与钙化缓解剂反应。
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公开(公告)号：US20130150869A1
公开(公告)日：2013-06-13
申请号：US13693952
申请日：2012-12-04
IPC分类号： A61B17/068
CPC分类号： A61B17/10 , A61B17/064 , A61B17/068 , A61B17/105 , A61B2017/0645 , A61B2017/0649
摘要： A device and method for deploying self-cinching surgical clips. The device accesses at least two layers of tissue or material from only one side of the tissue or material and punctures through the two layers of tissue or material. The various configurations of clips disclosed herein are made of a superelastic material such as Nitinol, and have a constrained and a relaxed state, and no sharp edges or tips so as to reduce tissue irritation following deployment. The clip is disposed within the housing of the delivery device and held in a constrained state by a tube assembly until deployment wherein the clip assumes its relaxed state, where the ends of the clip are brought into close approximation, thereby securing the layers of tissue or material together.
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