公开(公告)号：US20250017733A1

公开(公告)日：2025-01-16

申请号：US18901376

申请日：2024-09-30

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Tal Sheps ,  Yaron Herman ,  Aviv Galon ,  Meir Abucasis ,  Noam Nir

IPC: A61F2/24

Abstract: For repairing a valve situated between an atrium and a ventricle of a heart of a subject, and having a first leaflet and a second leaflet, apparatus is provided that includes an implant and a delivery tool. The implant includes a flexible patch defining slots along an edge of the patch; a first anchor; and a second anchor. The delivery tool is adapted to transluminally deliver the implant to the heart; and implant the implant in the ventricle by securing the patch against a ventricular surface of the first leaflet by anchoring the first anchor to the first leaflet, and against a ventricular surface of the second leaflet by anchoring the second anchor to the second leaflet, such that (i) chordae of the valve extend through the slots, and (ii) the patch bridges a gap between the first leaflet and the second leaflet. Other embodiments are also disclosed.

公开(公告)号：US12186185B2

公开(公告)日：2025-01-07

申请号：US17863195

申请日：2022-07-12

Applicant: Edwards Lifesciences Corporation

Inventor： Dikla Kersh ,  Michael Bukin ,  Tamir S. Levi ,  Noam Nir

IPC: A61F2/24

Abstract: A prosthetic valve assembly includes a radially expandable and compressible annular frame. The frame includes a plurality of interconnected struts, which include a plurality of inner struts and a plurality of outer struts. The inner struts overlap adjacent outer struts at a plurality of pivot joints. Radial expansion or compression of the annular frame causes the inner struts to pivot relative to the outer struts at the pivot joints. The assembly also includes a valvular structure having a plurality of leaflets, each leaflet having a cusp edge portion. The assembly further includes one or more leaflet-supporting cords, each having a plurality of anchoring portions and a plurality of suspended portions, each suspended portion extending between two adjacent anchoring portions. The anchoring portions are affixed to respective anchoring features of the frame adjacent the pivot joints. The cusp edge portions of the leaflets are connected to the suspended portions.

公开(公告)号：US20240173124A1

公开(公告)日：2024-05-30

申请号：US18422384

申请日：2024-01-25

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Noam Nir ,  Michael Bukin ,  Ofir Witzman ,  Oren Cohen

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2439 ,  A61F2250/0021

Abstract: This disclosure is directed to self-expanding prosthetic heart valves having resistance-based mechanisms to control the rate of self-expansion of the prosthetic heart valves. In some examples, the prosthetic heart valve can be configured to radially self-expand to a partially radially expanded state, and can then be further radially expanded to the radially expanded state and/or locked in the radially expanded state by pulling an actuation member of the expansion and locking assembly. In other examples, the prosthetic heart valve can be configured to self-expand from the radially compressed state to the fully radially expanded state without mechanical actuation. In some examples, the resistance-based expansion control mechanisms can be disposed between delivery system actuators and valve frame components. In other examples, the resistance-based expansion control mechanisms can be disposed between delivery system actuators and other components of the delivery system.

公开(公告)号：US20240091004A1

公开(公告)日：2024-03-21

申请号：US18526391

申请日：2023-12-01

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Noam Nir ,  Michael Bukin ,  Eran Goldberg

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/91 ,  A61F2220/0091 ,  A61F2250/001 ,  A61F2250/0018

Abstract: An implantable prosthetic device can include a hybrid frame movable between a radially compressed configuration and a radially expanded configuration. The hybrid frame can include a mechanically-expandable first sub-frame comprising a plurality of struts pivotably coupled to one another, and a plastically deformable second sub-frame coupled to the first sub-frame. When the hybrid frame is in the expanded configuration, the second sub-frame can be configured to resist radial compression of the frame.

公开(公告)号：US20240081985A1

公开(公告)日：2024-03-14

申请号：US18509778

申请日：2023-11-15

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Noam Miller ,  Noam Nir ,  Michael Bukin

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/243 ,  A61F2220/0091

Abstract: Various examples of prosthetic heart valves, delivery apparatus, and methods of using such are disclosed herein. The prosthetic heart valves comprise frames that are movable between a radially-compressed configuration and one or more radially-expanded configurations. The frames of the prosthetic heart valves include actuation members and locking mechanisms configured to secure the frame in one or more radially-expanded configurations. In some examples, the actuation members and locking members are integrally formed with the frame. The frames of the prosthetic heart valves can be coupled to one or more shafts of a delivery apparatus via a threaded connection or a non-threaded connection.

公开(公告)号：US11723771B2

公开(公告)日：2023-08-15

申请号：US17150355

申请日：2021-01-15

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Noam Nir ,  Tomer Saar

IPC: A61F2/24

CPC classification number: A61F2/2454 ,  A61F2/243 ,  A61F2/2466 ,  A61F2/2487 ,  A61F2/2457 ,  A61F2002/249

Abstract: A method for improving leaflet prolapse and/or valve regurgitation associated with a heart valve involves delivering a spacer device into a ventricle of a heart using a delivery system comprising a catheter, fixing the spacer device to a wall of the ventricle, expanding the spacer device to reposition a papillary muscle disposed in the ventricle away from the wall, the papillary muscle being connected to a leaflet of an atrioventricular heart valve via chordae tendineae, and releasing the spacer device from the catheter.

公开(公告)号：US20230017301A1

公开(公告)日：2023-01-19

申请号：US17935891

申请日：2022-09-27

Applicant: Edwards Lifesciences Corporation

Inventor： Elena Sherman ,  Michael Bukin ,  Sandip Vasant Pawar ,  Shahram Zamani ,  Tamir S. Levi ,  Noam Nir ,  Yana Mayatskaya ,  Alexander Barash ,  Ziv Yohanan ,  Nikolay Gurovich ,  Itai Pelled

IPC: A61F2/24

Abstract: An implantable prosthetic device can include a frame movable between a radially compressed and a radially expanded configuration and a sealing member. The frame can include an inflow end portion, an outflow end portion, and a plurality of struts. The sealing member can be disposed around the frame and can include a cushioning layer comprising a plurality of texturized yarns extending along the longitudinal axis of the frame, and a base layer disposed between the cushioning layer and the frame.

公开(公告)号：US20220409368A1

公开(公告)日：2022-12-29

申请号：US17901662

申请日：2022-09-01

Applicant: Edwards Lifesciences Corporation

Inventor： Elena Sherman ,  Noam Nir

IPC: A61F2/24

Abstract: An assembly and associated method for a commissure of a prosthetic heart valve is disclosed. As one example, a method includes forming a plurality of commissures with the plurality of leaflets, wherein each commissure is formed by pairing a first commissure tab of a first leaflet with an adjacent, second commissure tab of a second leaflet, and coupling a support strip to the first and second commissure tabs via sutures forming stitches along the support strip, and, for each commissure, securing the commissure to a respective support of a frame by forming one or more suture loops around an external surface of the support strip and the respective support of the frame, the suture loops being formed by end portion extensions of the sutures.

公开(公告)号：US20220409367A1

公开(公告)日：2022-12-29

申请号：US17823466

申请日：2022-08-30

Applicant: Edwards Lifesciences Corporation

Inventor： Eran Goldberg ,  Noam Nir

IPC: A61F2/24

Abstract: Prosthetic valves can have a reinforcement member designed to protect various components of the valve and the surrounding tissues from damage. The reinforcement member can include a suture with a plurality of apertures. Sutures with apertures can be utilized within or as reinforcement members, which can be attached to a prosthetic valve to reinforce the prosthetic valve.

公开(公告)号：US20220370198A1

公开(公告)日：2022-11-24

申请号：US17881042

申请日：2022-08-04

Applicant: Edwards Lifesciences Corporation

Inventor： Noam Nir ,  Elena Sherman ,  Michael Bukin ,  Tamir S. Levi ,  Ziv Yohanan ,  David Maimon

IPC: A61F2/24

Abstract: An assembly and associated method for a commissure of a prosthetic heart valve is disclosed. As one example, a method includes forming a plurality of commissures with a plurality of leaflets of a prosthetic heart valve, wherein each commissure is formed by: folding each commissure tab of each leaflet into a series of overlapping layers, each folded commissure tab arranged outward of, in a lateral direction, a portion of a body of the leaflet that is directly connected to the commissure tab; pairing each folded commissure tab of each leaflet with a folded commissure tab of another leaflet; and securing at least a portion of the series of overlapping layers of each folded commissure tab in its folded configuration.