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公开(公告)号：US08394846B2
公开(公告)日：2013-03-12
申请号：US13361099
申请日：2012-01-30
申请人： Seok-Ki Choi , Paul R. Fatheree , Ryan Hudson , Keith Jendza , Robert Murray McKinnell , Vivek Sasikumar
发明人： Seok-Ki Choi , Paul R. Fatheree , Ryan Hudson , Keith Jendza , Robert Murray McKinnell , Vivek Sasikumar
CPC分类号： C07C237/20 , C07C243/32 , C07C319/12 , C07C323/22 , C07C323/41 , C07C323/60 , C07C2601/14 , C07D257/04
摘要： The invention is directed to compounds of formula I: wherein Ar, r, R3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula I have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.
摘要翻译： 本发明涉及式I化合物：其中Ar，r，R 3，X和R 5-7如说明书中所定义，及其药学上可接受的盐。 式I的化合物具有AT1受体拮抗剂活性和去皮质激素抑制活性。 本发明还涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号：US08227497B2
公开(公告)日：2012-07-24
申请号：US13165975
申请日：2011-06-22
IPC分类号： A61K31/4164 , C07D233/54
CPC分类号： C07D233/68 , C07D233/60 , C07D233/70 , C07D233/84 , C07D233/90 , C07D409/12
摘要： The invention relates to compounds having the formula: wherein: Q, W, Y, Z, r, and Ar are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译： 本发明涉及具有下式的化合物：其中：Q，W，Y，Z，r和Ar如说明书中所定义，及其药学上可接受的盐。 这些化合物具有AT1受体拮抗剂活性和neprilysin抑制活性。 本发明还涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号：US08106082B2
公开(公告)日：2012-01-31
申请号：US12898999
申请日：2010-10-06
申请人： Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Vivek Sasikumar
发明人： Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Vivek Sasikumar
IPC分类号： A61K31/41 , C07D257/04
CPC分类号： C07C323/60 , C07C259/06 , C07D207/16 , C07D257/04 , C07D403/12
摘要： The invention relates to compounds having the formula: wherein: Ar, r, R3, Z, X, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
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公开(公告)号：US07851467B2
公开(公告)日：2010-12-14
申请号：US11999609
申请日：2007-12-06
IPC分类号： A61K31/439 , A61K31/541
CPC分类号： C07D451/04
摘要： The invention provides novel benzoimidazolone-carboxamide-derived carbamate 5-HT4 receptor agonist compounds of formula (I): wherein R1, R2, R3, R4, a, and b are defined in the disclosure. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供了新的苯并咪唑酮 - 甲酰胺衍生的氨基甲酸酯5-HT 4受体激动剂式（I）化合物：其中R 1，R 2，R 3，R 4，a和b在本公开内容中定义。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20100261716A1
公开(公告)日：2010-10-14
申请号：US12689763
申请日：2010-01-19
申请人： Daniel Marquess , Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Adam A. Goldblum , Daniel D. Long , S. Derek Turner , Jyanwei Liu
发明人： Daniel Marquess , Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Adam A. Goldblum , Daniel D. Long , S. Derek Turner , Jyanwei Liu
IPC分类号： A61K31/541 , A61P1/00 , A61K31/496 , A61K31/46
CPC分类号： G01N33/5044 , C07D451/04 , G01N33/5008 , G01N2333/70571
摘要： The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供了新的吲唑 - 甲酰胺5-HT4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20090093417A1
公开(公告)日：2009-04-09
申请号：US12231858
申请日：2008-09-05
申请人： Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Vivek Sasikumar
发明人： Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Vivek Sasikumar
IPC分类号： A61K38/05 , C07D257/04 , C07D403/12 , A61K31/4025
CPC分类号： C07C323/60 , C07C259/06 , C07D207/16 , C07D257/04 , C07D403/12
摘要： The invention relates to compounds having the formula: wherein: Ar, r, R3, Z, X, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译： 本发明涉及具有下式的化合物：其中：Ar，r，R3，Z，X和R5-7如说明书中所定义，或其药学上可接受的盐。 这些化合物具有AT1受体拮抗剂活性和neprilysin抑制活性。 本发明还涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号：US07419989B2
公开(公告)日：2008-09-02
申请号：US11314591
申请日：2005-12-21
申请人： Paul Fatheree , Roland Gendron , Adam A Goldblum , Daniel D Long , Daniel Marquess , S. Derek Turner , Seok-Ki Choi
发明人： Paul Fatheree , Roland Gendron , Adam A Goldblum , Daniel D Long , Daniel Marquess , S. Derek Turner , Seok-Ki Choi
IPC分类号： C07D401/14
CPC分类号： C07D451/04
摘要： The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供了新的吲唑 - 甲酰胺5-HT 4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT 4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US07351704B2
公开(公告)日：2008-04-01
申请号：US11060195
申请日：2005-02-17
申请人： Daniel Marquess , Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Adam A. Goldblum , Daniel D. Long , S. Derek Turner , Jyanwei Liu
发明人： Daniel Marquess , Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Adam A. Goldblum , Daniel D. Long , S. Derek Turner , Jyanwei Liu
IPC分类号： A61K31/54 , A61K31/497 , A01N43/42 , C07D401/00 , C07D417/00
CPC分类号： G01N33/5044 , C07D451/04 , G01N33/5008 , G01N2333/70571
摘要： The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
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公开(公告)号：US07226950B2
公开(公告)日：2007-06-05
申请号：US11500078
申请日：2006-08-07
IPC分类号： A61K31/135 , C07C211/03
CPC分类号： C07D213/30 , A61K31/135 , A61K31/401 , A61K31/4152 , A61K31/417 , A61K31/4184 , A61K31/4402 , A61K31/4465 , A61K31/5375 , C07C217/08 , C07C217/30 , C07C217/36 , C07C217/76 , C07C217/84 , C07C255/54 , C07C2601/18 , C07C2602/10 , C07D207/09 , C07D211/26 , C07D213/38 , C07D213/65 , C07D215/20 , C07D233/56 , C07D233/64 , C07D235/06 , C07D295/13 , C07D317/54 , C07D333/16
摘要： The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the present invention, as well as therapeutic methods comprising administering such a compound or salt to a mammal (e.g. a human).
摘要翻译： 本发明提供了钠通道调节化合物，其可用于治疗与钠通道活性相关的疾病或病症，例如神经性疼痛。 本发明还提供包含本发明化合物的药物组合物，以及包括向哺乳动物（例如人）施用此类化合物或盐的治疗方法。
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公开(公告)号：US20060276467A1
公开(公告)日：2006-12-07
申请号：US11500078
申请日：2006-08-07
申请人： Seok-Ki Choi , Paul Fatheree , David Green , Daniel Marquess
发明人： Seok-Ki Choi , Paul Fatheree , David Green , Daniel Marquess
IPC分类号： A61K31/5377 , A61K31/445 , A61K31/40 , C07D207/04 , C07D211/20 , A61K31/138
CPC分类号： C07D213/30 , A61K31/135 , A61K31/401 , A61K31/4152 , A61K31/417 , A61K31/4184 , A61K31/4402 , A61K31/4465 , A61K31/5375 , C07C217/08 , C07C217/30 , C07C217/36 , C07C217/76 , C07C217/84 , C07C255/54 , C07C2601/18 , C07C2602/10 , C07D207/09 , C07D211/26 , C07D213/38 , C07D213/65 , C07D215/20 , C07D233/56 , C07D233/64 , C07D235/06 , C07D295/13 , C07D317/54 , C07D333/16
摘要： The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the present invention, as well as therapeutic methods comprising administering such a compound or salt to a mammal (e.g. a human).
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