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公开(公告)号：US09402840B2
公开(公告)日：2016-08-02
申请号：US14816237
申请日：2015-08-03
IPC分类号： A61K31/46 , C07D451/02
CPC分类号： A61K31/46 , C07D451/04
摘要： The invention provides a crystalline hydrochloride salt of 1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid {(1S,3R,5R)-8-[(R)-2-hydroxy-3-(methanesulfonyl-methyl-amino)propyl]-8-azabicyclo[3.2.1]oct-3-yl}amide or a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with 5-HT4 receptor activity, and processes useful for preparing such crystalline salt forms.
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公开(公告)号：US20140163063A1
公开(公告)日：2014-06-12
申请号：US14043585
申请日：2013-10-01
申请人： Daniel Marquess , Paul R. Fatheree , S. Derek Turner , Daniel D. Long , Seok-Ki Choi , Adam A. Goldblum , Daniel Genov
发明人： Daniel Marquess , Paul R. Fatheree , S. Derek Turner , Daniel D. Long , Seok-Ki Choi , Adam A. Goldblum , Daniel Genov
IPC分类号： C07D451/02
CPC分类号： C07D451/02 , C07D451/04
摘要： The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供新的喹啉酮 - 甲酰胺5-HT 4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US07875629B2
公开(公告)日：2011-01-25
申请号：US12234906
申请日：2008-09-22
申请人： Adam A. Goldblum , Seok-ki Choi , Paul R. Fatheree , Roland Gendron , Lan Jiang , Daniel D. Long , Daniel Marquess , S. Derek Turner
发明人： Adam A. Goldblum , Seok-ki Choi , Paul R. Fatheree , Roland Gendron , Lan Jiang , Daniel D. Long , Daniel Marquess , S. Derek Turner
IPC分类号： A61K31/46
CPC分类号： C07D451/04 , C07D453/02
摘要： The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供新的喹啉酮 - 甲酰胺5-HT 4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20100292223A1
公开(公告)日：2010-11-18
申请号：US12842389
申请日：2010-07-23
申请人： Paul FATHEREE , Roland GENDRON , Adam A. GOLDBLUM , Daniel D. LONG , Daniel MARQUESS , S. Derek TURNER , Seok-Ki CHOI
发明人： Paul FATHEREE , Roland GENDRON , Adam A. GOLDBLUM , Daniel D. LONG , Daniel MARQUESS , S. Derek TURNER , Seok-Ki CHOI
IPC分类号： A61K31/551 , A61K31/46 , A61K31/497 , A61K31/5377 , A61P1/00 , A61P1/04 , A61P1/10
CPC分类号： C07D451/04
摘要： The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供了新的吲唑 - 甲酰胺5-HT4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20080176895A1
公开(公告)日：2008-07-24
申请号：US12075669
申请日：2008-03-13
申请人： Daniel Marquess , Paul R. Fatheree , S. Derek Turner , Daniel D. Long , Seok-Ki Choi , Adam A. Goldblum , Daniel Genov
发明人： Daniel Marquess , Paul R. Fatheree , S. Derek Turner , Daniel D. Long , Seok-Ki Choi , Adam A. Goldblum , Daniel Genov
CPC分类号： C07D451/02 , C07D451/04
摘要： The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供新颖的喹啉酮 - 甲酰胺5-HT 4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT 4受体活性相关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20080132491A1
公开(公告)日：2008-06-05
申请号：US12008840
申请日：2008-01-15
申请人： Paul Fatheree , Roland Gendron , Adam A. Goldblum , Daniel D. Long , Daniel Marquess , S.Derek Turner , Seok-Ki Choi
发明人： Paul Fatheree , Roland Gendron , Adam A. Goldblum , Daniel D. Long , Daniel Marquess , S.Derek Turner , Seok-Ki Choi
IPC分类号： A61K31/551 , A61P1/00 , C07D471/08 , A61K31/439 , A61K31/496 , A61K31/5377
CPC分类号： C07D451/04
摘要： The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
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公开(公告)号：US07329752B2
公开(公告)日：2008-02-12
申请号：US11602888
申请日：2006-11-21
IPC分类号： A61K31/439 , A61K31/541 , C07D401/12 , C07D417/14
CPC分类号： C07D451/04
摘要： The invention provides novel benzoimidazolone-carboxamide-derived carbamate 5-HT4 receptor agonist compounds of formula (I): wherein R1, R2, R3, R4, a, and b are defined in the disclosure. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供新的苯并咪唑酮 - 甲酰胺衍生的氨基甲酸酯5-HT 4受体激动剂式（I）化合物：其中R 1，R 2， 在本公开中限定了R 3，R 4，R 4，a和b。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT 4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20150291580A1
公开(公告)日：2015-10-15
申请号：US14595492
申请日：2015-01-13
申请人： DANIEL MARQUESS , PAUL R. FATHEREE , S. DEREK TURNER , DANIEL D. LONG , SEOK-KI CHOI , ADAM A. GOLDBLUM
发明人： DANIEL MARQUESS , PAUL R. FATHEREE , S. DEREK TURNER , DANIEL D. LONG , SEOK-KI CHOI , ADAM A. GOLDBLUM
IPC分类号： C07D451/04
CPC分类号： C07D451/02 , C07D451/04
摘要： The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供新的喹啉酮 - 甲酰胺5-HT 4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20120058989A1
公开(公告)日：2012-03-08
申请号：US13082269
申请日：2011-04-07
申请人： Allan S. Wagman , Heinz E. Moser , Glenn A. McEnroe , James B. Aggen , Martin S. Linsell , Adam A. Goldblum , John H. Griffin , Lloyd J. Simons , Thomas R. Belliotti , Christina R. Harris , Toni-Jo Poel , Michael J. Melnick , Ricky D. Gaston
发明人： Allan S. Wagman , Heinz E. Moser , Glenn A. McEnroe , James B. Aggen , Martin S. Linsell , Adam A. Goldblum , John H. Griffin , Lloyd J. Simons , Thomas R. Belliotti , Christina R. Harris , Toni-Jo Poel , Michael J. Melnick , Ricky D. Gaston
IPC分类号： A61K31/553 , A61P31/04 , C07D498/14 , C07D471/14 , A61K31/55 , A61K31/5517
CPC分类号： C07D471/14 , C07D498/14 , C07D513/14
摘要： Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, D, E, G, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 公开了具有抗菌活性的化合物。 该化合物具有以下结构（I）：包括其立体异构体，药学上可接受的盐和前药，其中A，B，D，E，G，R 1，R 2，R 3，R 4，R 5，R 6和R 7如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。
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10.发明授权公开(公告)号：US07772239B2
公开(公告)日：2010-08-10
申请号：US11986212
申请日：2007-11-20
申请人： Roland Gendron , Seok-ki Choi , Paul R. Fatheree , Adam A. Goldblum , Daniel D. Long , Daniel Marquess , S. Derek Turner
发明人： Roland Gendron , Seok-ki Choi , Paul R. Fatheree , Adam A. Goldblum , Daniel D. Long , Daniel Marquess , S. Derek Turner
IPC分类号： A61K31/46 , A61K31/496 , A61P1/00
CPC分类号： C07D451/04 , A61K31/46 , A61K31/496
摘要： The invention provides novel benzoimidazolone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供新的苯并咪唑酮 - 甲酰胺5-HT4受体激动剂化合物。 本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与5-HT4受体活性有关的疾病的方法，以及可用于制备这些化合物的方法和中间体。
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