公开(公告)号：US20180162835A1

公开(公告)日：2018-06-14

申请号：US15837393

申请日：2017-12-11

Applicant: FORMA Therapeutics, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell ,  David R. Lancia, JR.

IPC: C07D401/06 ,  C07D487/04 ,  C07D471/04 ,  C07D239/88

CPC classification number: C07D401/06 ,  C07D239/88 ,  C07D471/04 ,  C07D487/04

Abstract: The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.

公开(公告)号：US09938300B2

公开(公告)日：2018-04-10

申请号：US15015566

申请日：2016-02-04

Applicant: Forma Therapeutics, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell

IPC: A01N43/90 ,  A61K31/519 ,  C07D471/00 ,  C07D487/00 ,  C07D513/04 ,  C07D487/04

CPC classification number: C07D513/04 ,  C07D487/04

Abstract: The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, X1, X2, X3, n, and m are described herein.

公开(公告)号：US12043623B2

公开(公告)日：2024-07-23

申请号：US17490482

申请日：2021-09-30

Applicant: Forma Therapeutics, Inc.

Inventor： Alexandre Joseph Buckmelter ,  Stephanos Ioannidis ,  Bruce Follows ,  Gary Gustafson ,  Minghua Wang ,  Justin Andrew Caravella ,  Zhongguo Wang ,  Edward L. Fritzen ,  Jian Lin

IPC: C07D473/00 ,  A61K31/522

CPC classification number: C07D473/00 ,  A61K31/522

Abstract: The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula:




where R1, R2, R3, R3′, R4, R5, X1, X2, X3, X4, and n are described herein.

公开(公告)号：US10519127B2

公开(公告)日：2019-12-31

申请号：US16179071

申请日：2018-11-02

Applicant: FORMA Therapeutics, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell ,  David R. Lancia, Jr.

IPC: C07D401/06 ,  C07D239/88 ,  C07D487/04 ,  C07D471/04

Abstract: The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.

公开(公告)号：US20190308980A1

公开(公告)日：2019-10-10

申请号：US16449599

申请日：2019-06-24

Applicant: FORMA Therapeutics, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell

IPC: C07D487/04

Abstract: The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, R6, X1, X2, m, and n are described herein.

公开(公告)号：US10399980B2

公开(公告)日：2019-09-03

申请号：US16051879

申请日：2018-08-01

Applicant: FORMA Therapeutics, Inc.

Inventor： Alexandre Joseph Buckmelter ,  Stephanos Ioannidis ,  Bruce Follows ,  Gary Gustafson ,  Minghua Wang ,  Justin A. Caravella ,  Zhongguo Wang ,  Edward L. Fritzen ,  Jian Lin

IPC: C07D473/00 ,  A61K31/522

Abstract: The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: where R1, R2, R3, R3′, R4, R5, X1, X2, X3, X4, and n are described herein.

公开(公告)号：US10351571B2

公开(公告)日：2019-07-16

申请号：US15988790

申请日：2018-05-24

Applicant: FORMA Therapeutics, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell

IPC: C07D487/04

Abstract: The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, R6, X1, X2, m, and n are described herein.

公开(公告)号：US20190071422A1

公开(公告)日：2019-03-07

申请号：US16179117

申请日：2018-11-02

Applicant: FORMA Therapeutics, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell ,  David R. Lancia, JR.

IPC: C07D401/06 ,  C07D487/04 ,  C07D471/04 ,  C07D239/88

CPC classification number: C07D401/06 ,  C07D239/88 ,  C07D471/04 ,  C07D487/04

Abstract: The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.

公开(公告)号：US20180346485A1

公开(公告)日：2018-12-06

申请号：US15907007

申请日：2018-02-27

Applicant: FORMA Therapeutics, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell

IPC: C07D513/04 ,  C07D487/04

CPC classification number: C07D513/04 ,  C07D487/04

Abstract: The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, X1, X2, X3, n, and m are described herein.

公开(公告)号：US20180346480A1

公开(公告)日：2018-12-06

申请号：US15909200

申请日：2018-03-01

Applicant: FORMA Therapeutics, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell ,  David R. Lancia, Jr.

IPC: C07D495/04 ,  A61K31/519

CPC classification number: C07D495/04 ,  A61K31/519 ,  Y02A50/463

Abstract: The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R5, R5′, X1, X2, n, and m are described herein.