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公开(公告)号：US20160015690A1
公开(公告)日：2016-01-21
申请号：US14615333
申请日：2015-02-05
Applicant: Gilead Sciences, Inc.
Inventor： Kerim Babaoglu , Gediminas Brizgys , Jake Cha , Xiaowu Chen , Hongyan Guo , Randall L. Halcomb , Xiaochun Han , Richard Huang , Hongtao Liu , Ryan McFadden , Michael L. Mitchell , Yingmei Qi , Paul A. Roethle , Lianhong Xu , Hong Yang
IPC: A61K31/428 , A61K31/497 , A61K31/496 , A61K45/06 , A61K31/444 , A61K31/4439 , A61K31/437 , A61K31/5377 , A61K31/513 , A61K31/436 , A61K31/5383 , A61K31/4375 , A61K31/501 , A61K31/538 , A61K31/551 , A61K31/506
CPC classification number: C07D277/82 , A61K31/428 , A61K31/436 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/4741 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/551 , A61K31/553 , A61K45/06 , C07D277/66 , C07D277/68 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/06 , C07D498/04 , A61K2300/00
Abstract: Compounds disclosed herein including compounds of formula I′: and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.
Abstract translation: 提供本文公开的化合物，包括式I'化合物及其盐。 还提供了包含本文公开的化合物的药物组合物，用于制备本文公开的化合物的方法，用于制备本文公开的化合物的中间体和使用本文公开的化合物治疗HIV感染的治疗方法。
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公开(公告)号：US12060351B2
公开(公告)日：2024-08-13
申请号：US17268245
申请日：2019-08-13
Applicant: Gilead Sciences, Inc.
Inventor： Stephen Ammann , Elizabeth M. Bacon , Gediminas Brizgys , Elbert Chin , Chienhung Chou , Jeromy J. Cottell , Marilyn Ndukwe , Marina Shatskikh , James G. Taylor , Nathan E. Wright , Zheng-Yu Yang , Sheila M. Zipfel
IPC: C07D471/04 , C07D487/04 , C07D519/00
CPC classification number: C07D471/04 , C07D487/04 , C07D519/00
Abstract: A compound of Formula (I):
pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.-
![Pyrrolo[1,2-b] pyridazine derivatives](/abs-image/US/2022/12/27/US11535622B2/abs.jpg.150x150.jpg)
公开(公告)号：US11535622B2
公开(公告)日：2022-12-27
申请号：US17110734
申请日：2020-12-03
Applicant: Gilead Sciences, Inc.
Inventor： Stephen Ammann , Elizabeth M. Bacon , Gediminas Brizgys , Elbert Chin , Chienhung Chou , Jeromy J. Cottell , Marilyn Ndukwe , James G. Taylor , Nathan E. Wright , Zheng-Yu Yang , Sheila M. Zipfel
IPC: A61K31/5025 , C07D487/04
Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof, wherein the variable substituents are disclosed herein.
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公开(公告)号：US20220402910A1
公开(公告)日：2022-12-22
申请号：US17204463
申请日：2021-03-17
Applicant: Gilead Sciences, Inc.
Inventor： Stephen Ammann , Elizabeth M. Bacon , Gediminas Brizgys , Elbert Chin , Chienhung Chou , Jeromy J. Cottell , Marilyn Ndukwe , Marina Shatskikh , James G. Taylor , Nathan E. Wright , Zheng-Yu Yang , Sheila M. Zipfel
IPC: C07D471/04 , C07D487/04
Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.
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公开(公告)号：US11267801B2
公开(公告)日：2022-03-08
申请号：US17062676
申请日：2020-10-05
Applicant: Gilead Sciences, Inc.
Inventor： Gediminas Brizgys , Eda Canales , Chienhung Chou , Michael Graupe , Jiayao Li , Roland D. Saito , Scott D. Schroeder , Winston C. Tse , Qiaoyin Wu , Jennifer R. Zhang
IPC: C07D401/14 , A61P31/18 , C07D405/14 , C07D413/14
Abstract: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.
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Patent Agency Ranking
公开(公告)号：US11117886B2
公开(公告)日：2021-09-14
申请号：US16869653
申请日：2020-05-08
Applicant: Gilead Sciences, Inc.
Inventor： Amanda Lynn Vandehey , Gediminas Brizgys , Vinh Xuan Ngo , Brian Michael O'Keefe , Trevor James Rainey , Bing Shi , Winston C. Tse , Anna Michelle Wagner , Xianghong Wang , Scott Alan Wolckenhauer , Jennifer R. Zhang
IPC: C07D401/14 , C07D401/12 , C07D495/10 , C07D339/06 , C07C59/50 , C07D231/56 , C07C45/67 , C07D213/61 , C07D231/54
Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.
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公开(公告)号：US20210171498A1
公开(公告)日：2021-06-10
申请号：US17062676
申请日：2020-10-05
Applicant: Gilead Sciences, Inc.
Inventor： Gediminas Brizgys , Eda Canales , Chienhung Chou , Michael Graupe , Jiayao Li , Roland D. Saito , Scott D. Schroeder , Winston C. Tse , Qiaoyin Wu , Jennifer R. Zhang
IPC: C07D401/14 , A61P31/18 , C07D405/14 , C07D413/14
Abstract: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.
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公开(公告)号：US20200079769A1
公开(公告)日：2020-03-12
申请号：US16539834
申请日：2019-08-13
Applicant: Gilead Sciences, Inc.
Inventor： Stephen Ammann , Elizabeth M. Bacon , Gediminas Brizgys , Elbert Chin , Chienhung Chou , Jeromy J. Cottell , Marilyn Ndukwe , Marina Shatskikh , James G. Taylor , Nathan E. Wright , Zheng-Yu Yang , Sheila M. Zipfel
IPC: C07D471/04 , C07D487/04
Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.
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![PYRROLO[1,2-b]PYRIDAZINE DERIVATIVES](/abs-image/US/2020/02/13/US20200048261A1/abs.jpg.150x150.jpg)
公开(公告)号：US20200048261A1
公开(公告)日：2020-02-13
申请号：US16537385
申请日：2019-08-09
Applicant: Gilead Sciences, Inc.
Inventor： Stephen Ammann , Elizabeth M. Bacon , Gediminas Brizgys , Elbert Chin , Chienhung Chou , Jeromy J. Cottell , Marilyn Ndukwe , James G. Taylor , Nathan E. Wright , Zheng-Yu Yang , Sheila M. Zipfel
IPC: C07D487/04
Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.
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公开(公告)号：US20190300505A1
公开(公告)日：2019-10-03
申请号：US16277552
申请日：2019-02-15
Applicant: Gilead Sciences, Inc.
Inventor： Kevin McCormack Allan , Amanda Lynn Batten , Gediminas Brizgys , Sachin Dhar , Ian James Doxsee , Alex Goldberg , Lars V. Heumann , Zilin Huang , Nathaniel Thomas Kadunce , Shahrokh Kazerani , Willard Lew , Vinh Xuan Ngo , Brian Michael O'Keefe , Trevor James Rainey , Benjamin James Roberts , Bing Shi , Dietrich P. Steinhuebel , Winston C. Tse , Anna Michelle Wagner , Xianghong Wang , Scott Alan Wolckenhauer , Chloe Yuyi Wong , Jennifer R. Zhang
IPC: C07D401/14
Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.
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