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公开(公告)号:US20220267302A1
公开(公告)日:2022-08-25
申请号:US17584643
申请日:2022-01-26
发明人: Gediminas Brizgys , Eda Canales , Chienhung Chou , Michael Graupe , Jiayao Li , Roland D. Saito , Scott D. Schroeder , Winston C. Tse , Qiaoyin Wu , Jennifer R. Zhang
IPC分类号: C07D401/14 , A61P31/18 , C07D405/14 , C07D413/14
摘要: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.
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公开(公告)号:US20210009555A1
公开(公告)日:2021-01-14
申请号:US16882804
申请日:2020-05-26
发明人: Gediminas Brizgys , Eda Canales , Chien-Hung Chou , Michael Graupe , Randall L. Halcomb , Yunfeng Eric Hu , Scott E. Lazerwith , John O. Link , Qi Liu , Yafan Lu , Roland D. Saito , Scott D. Schroeder , John R. Somoza , Winston C. Tse , Jennifer R. Zhang
IPC分类号: C07D401/12 , C07D401/14 , C07D403/14 , C07D471/04 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D491/052 , C07D401/04 , C07D413/14 , C07D417/14 , C07D487/04
摘要: Compounds of formula (I) or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
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公开(公告)号:US20200262815A1
公开(公告)日:2020-08-20
申请号:US16694332
申请日:2019-11-25
发明人: Michael Graupe , Steven J. Henry , John O. Link , Charles William Rowe , Roland D. Saito , Scott D. Schroeder , Dimitrios Stefanidis , Winston C. Tse , Jennifer R. Zhang
IPC分类号: C07D401/14 , A61K31/4439 , A61K31/537 , A61K31/675 , A61K31/7076 , A61K45/06 , C07F5/02 , C07C317/08 , C07D231/54
摘要: The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.
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公开(公告)号:US10316017B2
公开(公告)日:2019-06-11
申请号:US15697755
申请日:2017-09-07
发明人: Elizabeth M. Bacon , Gayatri Balan , Chien-Hung Chou , Christopher T. Clark , Jeromy J. Cottell , Musong Kim , Thorsten A. Kirschberg , John O. Link , Gary Phillips , Scott D. Schroeder , Neil H. Squires , Kirk L. Stevens , James G. Taylor , William J. Watkins , Nathan E. Wright , Sheila M. Zipfel
IPC分类号: C07D401/12 , C07D453/02 , C07D417/14 , C07D413/14 , C07D413/12 , C07D409/14 , C07D405/14 , C07D401/14 , C07F7/08
摘要: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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公开(公告)号:US20180194746A1
公开(公告)日:2018-07-12
申请号:US15902883
申请日:2018-02-22
发明人: Steven S. Bondy , Carina E. Cannizzaro , Chien-Hung Chou , Randall L. Halcomb , Yunfeng Eric Hu , John O. Link , Qi Liu , Scott D. Schroeder , Winston C. Tse , Jennifer R. Zhang
IPC分类号: C07D401/12 , A61K31/4545 , C07D213/40 , C07D409/14 , C07D413/14 , A61K31/4439 , A61K31/444 , C07D491/052 , A61K31/4709 , A61K31/4985 , A61K31/50 , A61K31/506 , A61K31/5377 , C07D495/04 , C07D491/04 , C07D487/04 , C07D471/06 , C07D471/04 , C07D405/12 , C07D403/14 , C07D403/12 , C07D401/14 , A61K45/06
CPC分类号: C07D401/12 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4985 , A61K31/50 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/40 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/06 , C07D487/04 , C07D491/04 , C07D491/052 , C07D495/04
摘要: The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
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公开(公告)号:US08822430B2
公开(公告)日:2014-09-02
申请号:US13956195
申请日:2013-07-31
发明人: Elizabeth M. Bacon , Eda Canales , Aesop Cho , Jeromy J. Cottell , Manoj C. Desai , Michael Graupe , Hongyan Guo , Randall L. Halcomb , Darryl Kato , Choung U. Kim , Thorsten A. Kirschberg , Evan S. Krygowski , Scott E. Lazerwith , John O. Link , Hongtao Liu , Qi Liu , Richard L. Mackman , Michael L. Mitchell , Jay P. Parrish , Hyung-Jung Pyun , Joseph H. Saugier , Scott D. Schroeder , Jianyu Sun , James G. Taylor , James D. Trenkle , Winston C. Tse , Randall W. Vivian , William J. Watkins , Lianhong Xu
IPC分类号: C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D495/04 , A61K31/4178 , A61K31/7068 , A61K31/7052 , A61K31/4184 , A61P1/16 , A61P31/14
CPC分类号: C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
摘要: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号:US20230012449A1
公开(公告)日:2023-01-12
申请号:US17241138
申请日:2021-04-27
发明人: Steven S. Bondy , Carina E. Cannizzaro , Chien-Hung Chou , Randall L. Halcomb , Yunfeng E. Hu , John O. Link , Qi Liu , Scott D. Schroeder , Winston C. Tse , Jennifer R. Zhang
IPC分类号: C07D401/12 , C07D213/40 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D471/04 , C07D471/06 , C07D487/04 , C07D491/04 , C07D495/04 , C07C403/14 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4985 , A61K31/50 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D409/14 , C07D413/14 , C07D491/052
摘要: The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
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公开(公告)号:US20220306614A1
公开(公告)日:2022-09-29
申请号:US17690851
申请日:2022-03-09
发明人: Gediminas J. Brizgys , Chienhung Chou , Jeromy J. Cottell , Chao-I Hung , Michael L. Mitchell , Scott D. Schroeder , Nathan D. Shapiro , Suzanne M. Szewczyk , James G. Taylor , Nathan E. Wright , Sheila M. Zipfel
IPC分类号: C07D405/14 , A61K31/4545 , A61K45/06 , C07D401/14 , A61K31/4725 , C07D413/14 , C07D417/14
摘要: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.
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公开(公告)号:US11267801B2
公开(公告)日:2022-03-08
申请号:US17062676
申请日:2020-10-05
发明人: Gediminas Brizgys , Eda Canales , Chienhung Chou , Michael Graupe , Jiayao Li , Roland D. Saito , Scott D. Schroeder , Winston C. Tse , Qiaoyin Wu , Jennifer R. Zhang
IPC分类号: C07D401/14 , A61P31/18 , C07D405/14 , C07D413/14
摘要: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.
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公开(公告)号:US20210171498A1
公开(公告)日:2021-06-10
申请号:US17062676
申请日:2020-10-05
发明人: Gediminas Brizgys , Eda Canales , Chienhung Chou , Michael Graupe , Jiayao Li , Roland D. Saito , Scott D. Schroeder , Winston C. Tse , Qiaoyin Wu , Jennifer R. Zhang
IPC分类号: C07D401/14 , A61P31/18 , C07D405/14 , C07D413/14
摘要: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.
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