公开(公告)号：US07505814B2

公开(公告)日：2009-03-17

申请号：US10810437

申请日：2004-03-26

申请人： Gene A. Bornzin ,  Euljoon Park

发明人： Gene A. Bornzin ,  Euljoon Park

IPC分类号： A61N1/08 ,  A61B5/053

CPC分类号： A61N1/36521 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/0422 ,  A61B5/0464 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/4839 ,  A61B5/7207 ,  A61N1/3627

摘要： Briefly, values representative of ventricular end-diastolic volume (EDV) are detected using ventricular electrodes and then heart failure, if occurring within the patient, is evaluated based on ventricular EDV. In this manner, ventricular EDV is used as a proxy for ventricular end-diastolic pressure. By using ventricular EDV instead of ventricular end-diastolic pressure, heart failure is detected and evaluated without requiring sophisticated sensors or complex algorithms. Instead, ventricular EDV is easily and reliably measured using impedance signals sensed by implanted ventricular pacing/sensing electrodes. The severity of heart failure is also evaluated based on ventricular EDV values and heart failure progression is tracked based on changes, if any, in ventricular EDV values over time.

摘要翻译： 简而言之，使用心室电极检测代表心室舒张末期容积（EDV）的值，然后如果发生在患者体内，则基于心室EDV评估心力衰竭。 以这种方式，使用心室EDV作为心室舒张末期压力的代表。 通过使用心室EDV而不是心室舒张末期压力，可以检测和评估心力衰竭，而不需要复杂的传感器或复杂的算法。 相反，使用由植入式心室起搏/感测电极感测的阻抗信号容易且可靠地测量心室EDV。 还根据心室EDV值评估心力衰竭的严重程度，并且基于心室EDV值随时间的变化（如果有的话）跟踪心力衰竭进展。

公开(公告)号：US07283873B1

公开(公告)日：2007-10-16

申请号：US10838692

申请日：2004-05-03

申请人： Euljoon Park ,  Gene A. Bornzin

发明人： Euljoon Park ,  Gene A. Bornzin

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/3682

摘要： An implantable cardiac stimulation device is configured to measure selected ventricular contraction parameters and apply stimulation therapy based on an analysis of the ventricular contraction parameters. The ventricular contraction parameters may include impedance values that correspond to the volume of fluid in the right ventricle and the left ventricle. The ventricular contraction parameters may include motion values that correspond to heart sounds/motion in the right ventricle and the left ventricle. The ventricular contraction parameters can be used to form a ventricular parameter loop associated with one or more cardiac cycles. The total area within the resulting loop should be maintained below a threshold value through the application of applicable stimulation therapy and/or further physician assistance.

摘要翻译： 可植入心脏刺激装置被配置为测量所选择的心室收缩参数并且基于对心室收缩参数的分析来应用刺激疗法。 心室收缩参数可以包括对应于右心室和左心室中的流体体积的阻抗值。 心室收缩参数可以包括对应于右心室和左心室的心音/运动的运动值。 心室收缩参数可用于形成与一个或多个心动周期相关的心室参数循环。 通过应用适用的刺激疗法和/或进一步的医师帮助，所得环路内的总面积应保持在阈值以下。

公开(公告)号：US07212861B1

公开(公告)日：2007-05-01

申请号：US10838939

申请日：2004-05-03

申请人： Euljoon Park ,  Gene A. Bornzin ,  Robert G. Turcott

发明人： Euljoon Park ,  Gene A. Bornzin ,  Robert G. Turcott

IPC分类号： A61N1/00

CPC分类号： A61N1/36585 ,  A61N1/3627

摘要： An implantable cardiac stimulation device is configured to measure selected ventricular contraction parameters and possibly apply stimulation therapy based on the ventricular contraction parameters. In accordance with one aspect, the ventricular contraction parameters include impedance values that correspond to the volume of fluid in the right ventricle and the left ventricle. In accordance with another aspect, the ventricular contraction parameters include motion values that correspond to heart sounds/motion in the right ventricle and the left ventricle. The ventricular contraction parameters can be used to form pseudo P-V loop from which treatment decisions can be made.

摘要翻译： 可植入心脏刺激装置被配置为测量所选择的心室收缩参数，并且可以基于心室收缩参数应用刺激治疗。 根据一个方面，心室收缩参数包括对应于右心室和左心室中的流体体积的阻抗值。 根据另一方面，心室收缩参数包括对应于右心室和左心室中的心音/运动的运动值。 心室收缩参数可用于形成伪P-V循环，从中可以进行治疗决定。

公开(公告)号：US07085603B1

公开(公告)日：2006-08-01

申请号：US10353104

申请日：2003-01-27

申请人： Joseph J. Florio ,  Euljoon Park ,  Kerry Bradley ,  Gene A. Bornzin

发明人： Joseph J. Florio ,  Euljoon Park ,  Kerry Bradley ,  Gene A. Bornzin

IPC分类号： A61N1/365

CPC分类号： A61N1/3712 ,  A61N1/3627

摘要： A system and corresponding method are provided to reliably detect capture during multi-chamber stimulation, and to further monitor the progression of congestive heart failure. The system provides a method by which intracardiac electrogram (IEGM) characteristics representing single-chamber capture and bi-ventricular capture are stored in memory and displayed. The annotation of the displayed waveforms is such that events associated with loss of capture, single-chamber capture, and bi-ventricular capture are clearly marked for ready interpretation by the physician. In a first situation, a stimulation pulse is followed by a time delay window and a subsequent depolarization complex that represents intrinsic responses of the chambers that have not been captured. In a second situation, a stimulation pulse is followed almost immediately by an evoked response that represents capture of one chamber, and a subsequent depolarization complex that represents an intrinsic response of one chamber that has not been captured. In a third situation, a stimulation pulse is almost immediately followed by an evoked response that represents simultaneous capture of two chambers.

公开(公告)号：US06351672B1

公开(公告)日：2002-02-26

申请号：US09359025

申请日：1999-07-22

申请人： Euljoon Park ,  Gene A. Bornzin ,  Junyu Mai

发明人： Euljoon Park ,  Gene A. Bornzin ,  Junyu Mai

IPC分类号： A61N1365

CPC分类号： A61N1/36542

摘要： A system and method are provided for compensating for the drop in blood pressure upon standing. Upon transition from prolonged sitting, lying down, or standing position, the pacemaker abruptly increasing its pacing rate upon postural transition. The pacing rate is abruptly increased to about 80-100 bpm in 20 seconds-one minute. The pacing rate then decreases slowly to another high rate in two or three minutes and then follows the metabolically indicated rate. This pacing rate is triggered whenever a patient stands after a prolonged reclined or supine/prone position as indicated by activity variance measurements.

摘要翻译： 提供了一种用于补偿静置时血压下降的系统和方法。 从长时间的坐姿，躺下或站姿转移时，起搏器在姿势转换时突然增加起搏速度。 起搏速度在20秒内突然增加到约80-100 bpm（一分钟）。 然后起搏速度在两分钟或三分钟内缓慢下降到另一个高速率，然后遵循代谢指示的速率。 如果患者在经过长时间倾斜或仰卧/俯卧位置后站立时进行起搏速度，如活动方差测量所示。

公开(公告)号：US06275733B1

公开(公告)日：2001-08-14

申请号：US09334861

申请日：1999-06-16

申请人： Euljoon Park ,  Gene A. Bornzin ,  Joseph J. Florio ,  Saul E. Greenhut

发明人： Euljoon Park ,  Gene A. Bornzin ,  Joseph J. Florio ,  Saul E. Greenhut

IPC分类号： A61N1365

CPC分类号： A61N1/36585

摘要： A pacing system which determines a dual indicated rate (DIR) corresponding to a desired pacing rate of the heart of the patient by selecting the maximum between an activity indicated rate (AIR) and a metabolic indicated rate (MIR). The activity indicated rate is a pacing rate that is determined based upon a well-known acceleration-based sensor. The metabolic indicated rate is a desired pacing rate of the heart as determined based upon a well-known metabolic sensor, such as a minute ventilation sensor. Determining the dual indicated rate by selecting between the two rates provided by these two sensors results in the advantageous use of the activity indicated rate during periods of low-level and brisk activity and the use of the metabolic indicated rate during periods of high exertion.

摘要翻译： 一种起搏系统，其通过选择活动指示速率（AIR）和代谢指示速率（MIR）之间的最大值来确定对应于患者心脏的期望起搏速率的双指示速率（DIR）。 活动指示率是基于众所周知的基于加速度的传感器确定的起搏速率。 代谢指示速率是基于众所周知的代谢传感器（例如分钟通气传感器）确定的心脏的期望起搏速率。 通过在这两个传感器提供的两个速率之间进行选择来确定双指示率导致在低水平和轻快活动期间有利地使用活动指示速率，并且在高消耗期间使用代谢指示速率。

公开(公告)号：US6044294A

公开(公告)日：2000-03-28

申请号：US766636

申请日：1996-12-13

申请人： Said Mortazavi ,  Euljoon Park ,  Gene A. Bornzin ,  Joseph J. Florio ,  Jason A. Sholder ,  Robert R. Weyant

发明人： Said Mortazavi ,  Euljoon Park ,  Gene A. Bornzin ,  Joseph J. Florio ,  Jason A. Sholder ,  Robert R. Weyant

IPC分类号： A61N1/365 ,  A61B5/05

CPC分类号： A61N1/36521

摘要： Methods and apparatus are provided for measuring the impedance of a patient's body. Pulse generating circuitry within a rate-responsive pacemaker is used to generate an impedance measurement signal that is applied to the body of the patient with conventional pacemaker leads. The impedance measurement signal contains a series of multiphasic impedance measurement waveforms, which have no net DC value and zero value after second integration. The impedance measurement signal allows the impedance of the body to be measured without interfering with external cardiac monitoring equipment such as electrocardiogram machines.

摘要翻译： 提供了用于测量患者身体阻抗的方法和装置。 速率响应起搏器内的脉冲发生电路用于产生用常规起搏器引线施加到患者身体的阻抗测量信号。 阻抗测量信号包含一系列多相阻抗测量波形，其在第二次积分后不具有净DC值和零值。 阻抗测量信号允许测量身体的阻抗，而不会干扰外部心脏监测设备，如心电图仪。

公开(公告)号：US08306623B2

公开(公告)日：2012-11-06

申请号：US13149507

申请日：2011-05-31

申请人： Louis Wong ,  Cem Shaquer ,  Gene A. Bornzin ,  Euljoon Park ,  Andre Walker ,  Dorin Panescu ,  Jiong Xia ,  Shahrooz Shahparnia

发明人： Louis Wong ,  Cem Shaquer ,  Gene A. Bornzin ,  Euljoon Park ,  Andre Walker ,  Dorin Panescu ,  Jiong Xia ,  Shahrooz Shahparnia

IPC分类号： A61N1/18

CPC分类号： A61B5/02028 ,  A61B5/0031 ,  A61B5/029 ,  A61B5/0538 ,  A61B5/08 ,  A61B5/4878 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/3702

摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.

摘要翻译： 可植入系统采用可植入引线系统获得心内阻抗。 在一个实现中，该系统产生提供净零电荷和净零电压的富频率，低能量，多相波形。 当应用于身体组织时，具有多相波形的电流脉冲或电压脉冲在探测组织中提供增加的特异性和灵敏度。 所施加的脉冲的影响被感测为对应的波形。 施加和感测的脉冲的波形可以被积分，以获得表示频谱范围内的电流和电压的相应面积值。 可以比较这些区域以获得组织的可靠的阻抗值。 还可以测量频率响应，相位延迟和对调制脉冲宽度的响应，以确定组织的相对电容，指示梗死组织，血液与组织之比，水肿程度和其他生理参数。

公开(公告)号：US20110282226A1

公开(公告)日：2011-11-17

申请号：US12820879

申请日：2010-06-22

申请人： Michael E. Benser ,  Gene A. Bornzin ,  Euljoon Park ,  Kyungmoo Ryu ,  Michael Hardage

发明人： Michael E. Benser ,  Gene A. Bornzin ,  Euljoon Park ,  Kyungmoo Ryu ,  Michael Hardage

IPC分类号： A61B5/04

CPC分类号： A61B5/0422 ,  A61B5/0031 ,  A61B5/0464 ,  A61B18/1492 ,  A61N1/3621

摘要： A cardiac analysis system is provided that includes an implantable medical device (IMD), at least one sensor, and an external device. The IMD has electrodes positioned proximate to a heart that sense first cardiac signals of the heart and associated with a clinical ventricular tachycardia (VT) event and second cardiac signals associated with an induced VT event. The sensor measures first and second cardiac parameters of the heart associated with the clinical and induced VT events, respectively. The external device is configured to receive the first and second cardiac signals associated with the clinical and the induced VT events and the first and second cardiac parameters associated with the clinical and the induced VT events. The external device compares the first and second cardiac signals and compares the first and second cardiac parameters to determine if the clinical and induced VT events are a common type of VT event.

摘要翻译： 提供了包括可植入医疗装置（IMD），至少一个传感器和外部装置的心脏分析系统。 IMD具有位于心脏附近的电极，其感测心脏的第一心脏信号并与临床心室性心动过速（VT）事件和与诱导的VT事件相关联的第二心脏信号相关联。 该传感器分别测量与临床和诱导VT事件相关的心脏的第一和第二心脏参数。 外部设备被配置为接收与临床和诱导的VT事件相关联的第一和第二心脏信号以及与临床和诱导的VT事件相关联的第一和第二心脏参数。 外部设备比较第一和第二心脏信号，并比较第一和第二心脏参数以确定临床和诱导的VT事件是否是常见类型的VT事件。

公开(公告)号：US07945326B1

公开(公告)日：2011-05-17

申请号：US11684677

申请日：2007-03-12

申请人： Louis Wong ,  Cem Shaquer ,  Gene A. Bornzin ,  Euljoon Park ,  Andre Walker ,  Dorin Panescu

发明人： Louis Wong ,  Cem Shaquer ,  Gene A. Bornzin ,  Euljoon Park ,  Andre Walker ,  Dorin Panescu

IPC分类号： A61N1/18

CPC分类号： A61B5/02028 ,  A61B5/0031 ,  A61B5/029 ,  A61B5/0538 ,  A61B5/08 ,  A61B5/4878 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/3702

摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.

摘要翻译： 可植入系统采用可植入引线系统获得心内阻抗。 在一个实现中，该系统产生提供净零电荷和净零电压的富频率，低能量，多相波形。 当应用于身体组织时，具有多相波形的电流脉冲或电压脉冲在探测组织中提供增加的特异性和灵敏度。 所施加的脉冲的影响被感测为对应的波形。 施加和感测的脉冲的波形可以被积分，以获得表示频谱范围内的电流和电压的相应面积值。 可以比较这些区域以获得组织的可靠的阻抗值。 还可以测量频率响应，相位延迟和对调制脉冲宽度的响应，以确定组织的相对电容，指示梗死组织，血液与组织之比，水肿程度和其他生理参数。