公开(公告)号：US20160195486A1

公开(公告)日：2016-07-07

申请号：US14590950

申请日：2015-01-06

申请人： Mahmood Anvar ,  Louis Wong

发明人： Mahmood Anvar ,  Louis Wong

IPC分类号： G01N27/04 ,  G01N27/12

CPC分类号： G01N27/14 ,  G01N27/126 ,  G01N33/0031

摘要： A sensors reading when exposed to different chemical compounds changes if an operating condition of the sensor such as temperature, pressure, electromagnetic field intensity, light or radiation level is modified and the amount of change is different for different compounds. This invention uses this phenomenon to identify and quantify the concentration of the compound.

摘要翻译： 如果传感器的工作状态如温度，压力，电磁场强度，光或辐射水平被修改，并且不同化合物的变化量不同，则暴露于不同化学物质的传感器读数会发生变化。 本发明使用这种现象来鉴定和定量化合物的浓度。

公开(公告)号：US08306623B2

公开(公告)日：2012-11-06

申请号：US13149507

申请日：2011-05-31

申请人： Louis Wong ,  Cem Shaquer ,  Gene A. Bornzin ,  Euljoon Park ,  Andre Walker ,  Dorin Panescu ,  Jiong Xia ,  Shahrooz Shahparnia

发明人： Louis Wong ,  Cem Shaquer ,  Gene A. Bornzin ,  Euljoon Park ,  Andre Walker ,  Dorin Panescu ,  Jiong Xia ,  Shahrooz Shahparnia

IPC分类号： A61N1/18

CPC分类号： A61B5/02028 ,  A61B5/0031 ,  A61B5/029 ,  A61B5/0538 ,  A61B5/08 ,  A61B5/4878 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/3702

摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.

摘要翻译： 可植入系统采用可植入引线系统获得心内阻抗。 在一个实现中，该系统产生提供净零电荷和净零电压的富频率，低能量，多相波形。 当应用于身体组织时，具有多相波形的电流脉冲或电压脉冲在探测组织中提供增加的特异性和灵敏度。 所施加的脉冲的影响被感测为对应的波形。 施加和感测的脉冲的波形可以被积分，以获得表示频谱范围内的电流和电压的相应面积值。 可以比较这些区域以获得组织的可靠的阻抗值。 还可以测量频率响应，相位延迟和对调制脉冲宽度的响应，以确定组织的相对电容，指示梗死组织，血液与组织之比，水肿程度和其他生理参数。

公开(公告)号：US07945326B1

公开(公告)日：2011-05-17

申请号：US11684677

申请日：2007-03-12

申请人： Louis Wong ,  Cem Shaquer ,  Gene A. Bornzin ,  Euljoon Park ,  Andre Walker ,  Dorin Panescu

发明人： Louis Wong ,  Cem Shaquer ,  Gene A. Bornzin ,  Euljoon Park ,  Andre Walker ,  Dorin Panescu

IPC分类号： A61N1/18

CPC分类号： A61B5/02028 ,  A61B5/0031 ,  A61B5/029 ,  A61B5/0538 ,  A61B5/08 ,  A61B5/4878 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/3702

摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.

摘要翻译： 可植入系统采用可植入引线系统获得心内阻抗。 在一个实现中，该系统产生提供净零电荷和净零电压的富频率，低能量，多相波形。 当应用于身体组织时，具有多相波形的电流脉冲或电压脉冲在探测组织中提供增加的特异性和灵敏度。 所施加的脉冲的影响被感测为对应的波形。 施加和感测的脉冲的波形可以被积分，以获得表示频谱范围内的电流和电压的相应面积值。 可以比较这些区域以获得组织的可靠的阻抗值。 还可以测量频率响应，相位延迟和对调制脉冲宽度的响应，以确定组织的相对电容，指示梗死组织，血液与组织之比，水肿程度和其他生理参数。

公开(公告)号：US20080221477A1

公开(公告)日：2008-09-11

申请号：US12088996

申请日：2005-10-11

申请人： Allan Olson ,  Louis Wong

发明人： Allan Olson ,  Louis Wong

IPC分类号： A61B5/053

CPC分类号： A61B5/053 ,  A61B5/0538 ,  A61N1/36521

摘要： In a method and device for measuring an electrical bio-impedance of a patient at least one impedance measurement signal is generated by a current pulse generator, the signal having at least one asymmetric multiphasic impedance measurement waveform that is asymmetric in term of pulse amplitude and/or pulse width relative to the operating voltage of the current pulse generator. The waveform has a DC component that is substantially equal to zero, and is adapted to the available voltage headroom of an implantable device that contains the current pulse generator. The impedance measurement signal with the aforementioned waveform is applied to a patient and a resulting impedance signal is produced thereby, from which at least one impedance value is determined.

摘要翻译： 在用于测量患者的电生物阻抗的方法和装置中，至少一个阻抗测量信号由电流脉冲发生器产生，所述信号具有至少一个不对称的多个非对称多相阻抗测量波形，其在脉冲幅度和/ 或相对于电流脉冲发生器的工作电压的脉冲宽度。 该波形具有基本上等于零的直流分量，并且适用于包含电流脉冲发生器的可植入装置的可用电压余量。 将具有上述波形的阻抗测量信号施加到患者，并且由此产生所得到的阻抗信号，从该阻抗信号确定至少一个阻抗值。

公开(公告)号：US20070288186A1

公开(公告)日：2007-12-13

申请号：US11702404

申请日：2007-02-05

申请人： Saswati Datta ,  William Belcher ,  Sandra Murawski ,  Mannie Clapp ,  Steven Page ,  Magda El-Nokaly ,  Richard Tweddell ,  Sohini Paldey ,  Louis Wong ,  Ronald Warner ,  Kerstin Nolkrantz ,  Chitra Laxmanan ,  Brian Ranade ,  Jianjun Li ,  Randall Marsh ,  Maria Sanchez Pena

发明人： Saswati Datta ,  William Belcher ,  Sandra Murawski ,  Mannie Clapp ,  Steven Page ,  Magda El-Nokaly ,  Richard Tweddell ,  Sohini Paldey ,  Louis Wong ,  Ronald Warner ,  Kerstin Nolkrantz ,  Chitra Laxmanan ,  Brian Ranade ,  Jianjun Li ,  Randall Marsh ,  Maria Sanchez Pena

IPC分类号： G01N33/48 ,  G01M19/00 ,  G06G7/58 ,  G01N19/02

CPC分类号： G01N19/02 ,  G01N2030/025 ,  G01N2203/0246

摘要： Method of product evaluation comprising the steps of applying at least one substance to a surface of an artificial substrate to form a substance-coated surface, wherein the substrate surface demonstrates at least one physical property selected from the group consisting of a total surface energy of from about 15 mJ/m2 to about 50 mJ/m2, a polar component of the total surface energy of from about 0 mJ/m2 to about 15 mJ/m2, a zeta-potential at a pH of about 5.0 of from about −30 mV to about 30 mV, and combinations thereof, and performing at least one analysis of the substance-coated surface.

摘要翻译： 产品评估方法包括以下步骤：将至少一种物质施加到人造基底的表面以形成物质涂覆的表面，其中所述基底表面显示出至少一种物理性质，所述物理性质选自以下物质的总表面能： 约15mJ / m 2至约50mJ / m 2，总表面能的极性分量为约0mJ / m 2 / >约15mJ / m 2，pH约为5.0，约-30mV至约30mV的ζ电位及其组合，并进行至少一种物质分析 涂层表面。

公开(公告)号：US08600497B1

公开(公告)日：2013-12-03

申请号：US11558088

申请日：2006-11-09

申请人： Weiqun Yang ,  Malin Ohlander ,  Louis Wong ,  Nils Holmstrom ,  Cem Shaquer ,  Euljoon Park ,  Dorin Panescu ,  Shahrooz Shahparnia ,  Andre Walker ,  Ajit Pillai ,  Mihir Naware

发明人： Weiqun Yang ,  Malin Ohlander ,  Louis Wong ,  Nils Holmstrom ,  Cem Shaquer ,  Euljoon Park ,  Dorin Panescu ,  Shahrooz Shahparnia ,  Andre Walker ,  Ajit Pillai ,  Mihir Naware

IPC分类号： A61B5/05 ,  A61N1/00

CPC分类号： A61B5/02028 ,  A61B5/0031 ,  A61B5/029 ,  A61B5/0538 ,  A61B5/08 ,  A61B5/4878 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/3702

摘要： An implantable device monitors and treats heart failure, pulmonary edema, and hemodynamic conditions and in some cases applies therapy. In one implementation, the implantable device applies a high-frequency multi-phasic pulse waveform over multiple-vectors through tissue. The waveform has a duration less than the charging time constant of electrode-electrolyte interfaces in vivo to reduce intrusiveness while increasing sensitivity and specificity for trending parameters. The waveform can be multiplexed over multiple vectors and the results cross-correlated or subjected to probabilistic analysis or thresholding schemata to stage heart failure or pulmonary edema. In one implementation, a fractionation morphology of a sensed impedance waveform is used to trend intracardiac pressure to stage heart failure and to regulate cardiac resynchronization therapy. The waveform also provides unintrusive electrode integrity checks and 3-D impedancegrams.

摘要翻译： 植入式装置监测和治疗心力衰竭，肺水肿和血液动力学状况，并且在某些情况下应用治疗。 在一个实施方案中，可植入装置通过组织在多个向量上施加高频多相脉冲波形。 该波形的持续时间小于体内电极 - 电解质界面的充电时间常数，以降低侵入性，同时增加趋势参数的灵敏度和特异性。 波形可以在多个载体上进行复用，并且结果相互关联或进行概率分析或阈值模式以分步心脏衰竭或肺水肿。 在一个实施方案中，使用感测阻抗波形的分级形态来趋向心脏内压力来分级心力衰竭并调节心脏再同步治疗。 该波形还提供非侵入式电极完整性检查和3-D阻抗图。

公开(公告)号：US08369458B2

公开(公告)日：2013-02-05

申请号：US11961964

申请日：2007-12-20

申请人： Louis Wong ,  Chungwen Dennis Lo

发明人： Louis Wong ,  Chungwen Dennis Lo

IPC分类号： H04L27/06

CPC分类号： H04B1/16 ,  H04B1/0032

摘要： A circuit is disclosed that comprises a controller and an analog to digital converter (ADC) coupled to controller. The speed and/or the resolution of the ADC is configurable to provide optimum performance during the operation of the ADC. In an embodiment a wireless receiver with an adaptively configurable ADC for is provided. The speed and resolution the ADC is configurable depending on the operational mode of the receiver. Accordingly, through the use of an adaptively configurable ADC, power consumption and speed is optimized for each operational mode.

摘要翻译： 公开了包括耦合到控制器的控制器和模数转换器（ADC）的电路。 ADC的速度和/或分辨率可配置为在ADC运行期间提供最佳性能。 在一个实施例中，提供了具有自适应可配置ADC的无线接收器。 ADC的速度和分辨率可根据接收机的工作模式进行配置。 因此，通过使用自适应配置的ADC，针对每种操作模式优化了功耗和速度。

公开(公告)号：US08032218B2

公开(公告)日：2011-10-04

申请号：US12183438

申请日：2008-07-31

申请人： Louis Wong ,  Dorin Panescu

发明人： Louis Wong ,  Dorin Panescu

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/37288 ,  A61N1/378

摘要： In one embodiment an implantable cardiac device is provided that includes an implantable cardiac stimulation device with an implantable satellite device coupled to it. The implantable satellite device has a charge storage device. The implantable stimulation device having a refresh generator configured to generate a charge and voltage balanced multi-phasic refresh signal with a duration less than a capacitive time constant of an electrode-electrolyte interface of the implantable cardiac device and transmit the charge and voltage balanced multi-phasic refresh signal to the implantable satellite device for charging the charge storage device. In various embodiments, the charge and voltage balanced multi-phasic refresh signal having alternating phase signs and null durations between the alternating phases. In some embodiments, the refresh generator is configured to modulate the multi-phasic waveform refresh signal. The multi-phasic waveform refresh signal may be modulated to contain configuration information, status information, or other information.

摘要翻译： 在一个实施例中，提供了可植入的心脏装置，其包括可植入的心脏刺激装置，其中可植入的卫星装置与其联接。 可植入式卫星装置具有电荷存储装置。 所述可植入刺激装置具有刷新发生器，其被配置为产生具有小于所述可植入心脏装置的电极 - 电解质界面的电容时间常数的持续时间的充电和电压平衡多相刷新信号，并且传送所述充电和电压平衡多相刷新信号， 相位刷新信号到可植入式卫星装置，用于对电荷存储装置充电。 在各种实施例中，充电和电压平衡的多相刷新信号在交替相位之间具有交替的相位符号和空持续时间。 在一些实施例中，刷新发生器配置成调制多相波形刷新信号。 可以调制多相波形刷新信号以包含配置信息，状态信息或其他信息。

公开(公告)号：US07917204B2

公开(公告)日：2011-03-29

申请号：US12088996

申请日：2005-10-11

申请人： Allan Olson ,  Louis Wong

发明人： Allan Olson ,  Louis Wong

IPC分类号： A61B5/053

CPC分类号： A61B5/053 ,  A61B5/0538 ,  A61N1/36521

摘要： In a method and device for measuring an electrical bio-impedance of a patient at least one impedance measurement signal is generated by a current pulse generator, the signal having at least one asymmetric multiphasic impedance measurement waveform that is asymmetric in term of pulse amplitude and/or pulse width relative to the operating voltage of the current pulse generator. The waveform has a DC component that is substantially equal to zero, and is adapted to the available voltage headroom of an implantable device that contains the current pulse generator. The impedance measurement signal with the aforementioned waveform is applied to a patient and a resulting impedance signal is produced thereby, from which at least one impedance value is determined.

摘要翻译： 在用于测量患者的电生物阻抗的方法和装置中，至少一个阻抗测量信号由电流脉冲发生器产生，所述信号具有至少一个不对称的多个非对称多相阻抗测量波形，其在脉冲幅度和/ 或相对于电流脉冲发生器的工作电压的脉冲宽度。 该波形具有基本上等于零的直流分量，并且适用于包含电流脉冲发生器的可植入装置的可用电压余量。 将具有上述波形的阻抗测量信号施加到患者，并且由此产生所得到的阻抗信号，从该阻抗信号确定至少一个阻抗值。

公开(公告)号：US20090161798A1

公开(公告)日：2009-06-25

申请号：US11961964

申请日：2007-12-20

申请人： Louis Wong ,  Chungwen Dennis Lo

发明人： Louis Wong ,  Chungwen Dennis Lo

IPC分类号： H04L27/06 ,  H03M1/12

CPC分类号： H04B1/16 ,  H04B1/0032

摘要： A circuit is disclosed that comprises a controller and an analog to digital converter (ADC) coupled to controller. The speed and/or the resolution of the ADC is configurable to provide optimum performance during the operation of the ADC. In an embodiment a wireless receiver with an adaptively configurable ADC for is provided. The speed and resolution the ADC is configurable depending on the operational mode of the receiver. Accordingly, through the use of an adaptively configurable ADC, power consumption and speed is optimized for each operational mode.

摘要翻译： 公开了包括耦合到控制器的控制器和模数转换器（ADC）的电路。 ADC的速度和/或分辨率可配置为在ADC运行期间提供最佳性能。 在一个实施例中，提供了具有自适应可配置ADC的无线接收器。 ADC的速度和分辨率可根据接收机的工作模式进行配置。 因此，通过使用自适应配置的ADC，针对每种操作模式优化了功耗和速度。