公开(公告)号：US3619374A

公开(公告)日：1971-11-09

申请号：US3619374D

申请日：1967-12-04

Applicant: HOFFMANN LA ROCHE

Inventor： BERGER JULIUS ,  KARR ANDREW E ,  LEIMGRUBER WILLY ,  TABENKIN BENJAMIN ,  SCHOCHER ARNO JOHANNES ,  STEFANOVIC VLADIMIR

IPC: C12D9/00

CPC classification number: C07D498/18 ,  Y10S435/886

Abstract: Antibiotics having antitumor and antibacterial activity are produced by fermentation of thermophilic actimomycetes Streptomyces refuineus var. thermotolerans, having NRRL numbers 3,143 and 3,144, in a nutrient medium containing a protein source and a carbohydrate source, at 35* C. to 55* C., extracting the fermentation broth with a solvent and isolating the active fraction.

公开(公告)号：US3546239A

公开(公告)日：1970-12-08

申请号：US3546239D

申请日：1968-01-05

Applicant: HOFFMANN LA ROCHE

Inventor： LEIMGRUBER WILLY ,  ZIERING ALBERT

IPC: C07D211/70 ,  C07D211/82 ,  C07D31/28

CPC classification number: C07D211/82 ,  C07D211/70