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31.发明授权公开(公告)号：US10953039B2
公开(公告)日：2021-03-23
申请号：US16144040
申请日：2018-09-27
发明人： James L. Hedrick , Simone Bianco , Mark Kunitomi , Yi Yan Yang , Xin Ding , Chuan Yang , Zhen Chang Liang , Paola Florez de Sessions , Balamurugan Periaswamy
IPC分类号： A61K31/785 , A61P31/04 , A61K31/407 , A61K31/496 , A61K31/7052 , A61K31/43
摘要： Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.
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公开(公告)号：US10752787B2
公开(公告)日：2020-08-25
申请号：US16675754
申请日：2019-11-06
发明人： Amos Cahan , Xin Ding , Mareva B. Fevre , James L. Hedrick , Zhen Chang Liang , Nathaniel H. Park , Theodore G. van Kessel , Rudy J. Wojtecki , Yi Yan Yang
IPC分类号： C09D5/14 , C09D161/22 , A01N33/08 , A01N31/16 , C09D181/02 , A01N33/10 , B05D1/02 , B05D1/00 , B29C39/38 , B29C39/26 , A01N25/10 , C09D5/16 , G03F7/00 , B05D5/02
摘要： Embodiments are directed to a method of making an antifouling and bactericidal coating with tailorable surface topology. The method includes depositing a layer of branched polyethyleneimine (BPEI) and diamino-functionalized poly(propylene oxide) (PPO) in a mixture of water and organic solvent on a substrate to form a layer of BPEI/PPO. The method includes depositing a layer of glyoxal in a water-containing solution on the layer of BPEI/PPO. The method further includes curing the layer of BPEI/PPO and layer of glyoxal to form a homogenous, glyoxal crosslinked BPEI/PPO coating, where the curing induces local precipitation and alteration of the glyoxal crosslinked BPEI/PPO coating to provide a textured surface.
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公开(公告)号：US20200221692A1
公开(公告)日：2020-07-16
申请号：US16744868
申请日：2020-01-16
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Yi Yan Yang
IPC分类号： A01N25/10 , A01N43/50 , A01N37/26 , C07C279/10 , C08L79/02 , C08G69/26 , C08G73/02 , A01N47/44 , C08L101/00
摘要： Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.
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公开(公告)号：US10687530B2
公开(公告)日：2020-06-23
申请号：US15839388
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Yi Yan Yang , Mu San Zhang
IPC分类号： A01N37/18 , C08G69/40 , A01N33/12 , A01N43/50 , C08L101/00
摘要： Techniques regarding ionene and/or polyionene compositions with antimicrobial functionality and enhanced hydrophilicity are provided. For example, one or more embodiments can regard a chemical compound that can comprise an ionene unit, which can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. The ionene unit can have antimicrobial functionality. Further, the chemical compound can comprise a hydrophilic functional group covalently bonded to the ionene unit. Also, the chemical compound can have carbohydrate mimetic functionality.
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公开(公告)号：US10561146B2
公开(公告)日：2020-02-18
申请号：US15824250
申请日：2017-11-28
发明人： Willy Chin , James L. Hedrick , Noah Frederick Fine Nathel , Victoria A. Piunova , Zhi Xiang Voo , Yi Yan Yang
摘要： Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.
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公开(公告)号：US10507267B2
公开(公告)日：2019-12-17
申请号：US15496473
申请日：2017-04-25
发明人： Amos Cahan , Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Theodore G. van Kessel , Rudy J. Wojtecki , Yi Yan Yang
IPC分类号： C09D183/04 , A61L31/10 , A61L29/08 , A61L29/16 , A61L31/16 , A61L27/34 , A61L27/54 , A61L27/50 , C08G75/20 , C09D181/06 , C08G75/0227 , C08G75/0213 , C09D181/02 , B05D5/00 , B05D1/00 , B05D3/02
摘要： Antibacterial coatings and methods of making the antibacterial coatings are described herein. In particular, a method for forming an organocatalyzed polythioether coating is provided in which a first solution including a bis-silylated dithiol and a fluoroarene is prepared. A second solution including an organocatalyst is prepared. The first solution and the second solution are mixed to form a mixed solution. The mixed solution is applied to a substrate, and the substrate is cured.
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公开(公告)号：US10457772B2
公开(公告)日：2019-10-29
申请号：US15699416
申请日：2017-09-08
申请人： International Business Machines Corporation , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (ASTAR)
发明人： Dylan J. Boday , Willy Chin , Jeannette M. Garcia , James L. Hedrick , Eunice Leong Jiayu , Shrinivas Venkataraman , Zhi Xiang Voo , Rudy J. Wojtecki , Yi Yan Yang
摘要： The present disclosure relates to polythioaminals with applications as carriers or delivery vehicles for therapeutic agents or other small molecule cargo. Polythioaminal block copolymer coupled to a therapeutic agent is a polymer-therapeutic conjugate that exhibits higher stability and longer life time in aqueous environments. The polythioaminal block copolymer coupled to a therapeutic agent can be synthesized by reacting hexahydrotriazines with a hydrophobic block precursor, a hydrophilic block precursor, a particle stabilizing segment precursor, and a cargo, such as a therapeutic agent, in a one pot synthesis. The ease of synthesizing the resulting polythioaminal block copolymer coupled to the therapeutic agent while offering the extended stability and polymer life time in aqueous environments make the polythioaminal block copolymer particularly attractive for therapeutic carriers.
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公开(公告)号：US20190177479A1
公开(公告)日：2019-06-13
申请号：US15839410
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chuan Yang , Yi Yan Yang
IPC分类号： C08G73/02 , C07C13/47 , A61K31/787 , A61K31/166 , A61P31/06
摘要： Techniques regarding killing of a pathogen with one or more ionene compositions having antimicrobial functionality are provided. For example, one or more embodiments can comprise a method, which can comprise contacting a mycobacterium tuberculosis microbe with a chemical compound. The chemical compound can comprise an ionene unit. Also, the ionene unit can comprise a cation distributed along a molecular backbone. The ionene unit can have antimicrobial functionality. The method can further comprise electrostatically disrupting a membrane of the mycobacterium tuberculosis microbe in response to the contacting.
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公开(公告)号：US20190174753A1
公开(公告)日：2019-06-13
申请号：US15839397
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chaun Yang , Yi Yan Yang
摘要： Techniques regarding ionene and/or polyionene compositions with antimicrobial functionalities are provided. For example, one or more embodiments can comprise a chemical compound, which can comprise an ionene unit. The ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a norspermidine structure having a carbonyl group. Also, the ionene unit can have antimicrobial functionality.
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公开(公告)号：US20180228835A1
公开(公告)日：2018-08-16
申请号：US15954776
申请日：2018-04-17
发明人： Willy Chin , Daniel J. Coady , Richard A. Dipietro , Amanda C. Engler , James L. Hedrick , Ashlynn L. Z. Lee , Victor W. L. Ng , Zhan-Yuin Ong , Yi Yan Yang
IPC分类号： A61K31/785 , C08G64/02 , A01N25/10 , A01N33/12 , A61K31/80
摘要： Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.
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