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公开(公告)号：US10457772B2
公开(公告)日：2019-10-29
申请号：US15699416
申请日：2017-09-08
申请人： International Business Machines Corporation , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (ASTAR)
发明人： Dylan J. Boday , Willy Chin , Jeannette M. Garcia , James L. Hedrick , Eunice Leong Jiayu , Shrinivas Venkataraman , Zhi Xiang Voo , Rudy J. Wojtecki , Yi Yan Yang
摘要： The present disclosure relates to polythioaminals with applications as carriers or delivery vehicles for therapeutic agents or other small molecule cargo. Polythioaminal block copolymer coupled to a therapeutic agent is a polymer-therapeutic conjugate that exhibits higher stability and longer life time in aqueous environments. The polythioaminal block copolymer coupled to a therapeutic agent can be synthesized by reacting hexahydrotriazines with a hydrophobic block precursor, a hydrophilic block precursor, a particle stabilizing segment precursor, and a cargo, such as a therapeutic agent, in a one pot synthesis. The ease of synthesizing the resulting polythioaminal block copolymer coupled to the therapeutic agent while offering the extended stability and polymer life time in aqueous environments make the polythioaminal block copolymer particularly attractive for therapeutic carriers.
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2.发明申请公开(公告)号：US20200164080A1
公开(公告)日：2020-05-28
申请号：US16201155
申请日：2018-11-27
IPC分类号： A61K47/59 , A61K31/4188 , A61K31/155 , A61K47/55
摘要： The subject disclosure is directed to techniques for enhancing the selectivity and efficacy of therapeutic polymers against a broad spectrum of pathogens and cancer cell lines. According to an embodiment, a method is provided that comprises forming a therapeutic polymer based on polymerization of a plurality of therapeutic monomers, wherein the therapeutic polymer provides a therapeutic functionality. The method further comprises attaching biotin to the therapeutic polymer, resulting in a biotin-functionalized therapeutic polymer, wherein the biotin-functionalized therapeutic polymer provides greater therapeutic efficacy relative to the therapeutic polymer.
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公开(公告)号：US11930818B2
公开(公告)日：2024-03-19
申请号：US16738517
申请日：2020-01-09
发明人： Victoria A. Piunova , Noah Frederick Fine Nathel , James L. Hedrick , Yi Yan Yang , Willy Chin , Zhi Xiang Voo
IPC分类号： A01N47/06 , A01N25/00 , C08G64/02 , C08G64/16 , C08G64/42 , C09D5/14 , C09D169/00 , C08G83/00
CPC分类号： A01N47/06 , A01N25/00 , C08G64/0241 , C08G64/1641 , C08G64/1658 , C08G64/42 , C09D5/14 , C09D169/00 , C08G83/004 , A01N25/00 , A01N43/90 , A01N59/00
摘要： Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.
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4.发明授权公开(公告)号：US11167036B2
公开(公告)日：2021-11-09
申请号：US16201155
申请日：2018-11-27
IPC分类号： A61K47/59 , A61K31/4188 , A61K31/155 , A61K47/55
摘要： The subject disclosure is directed to techniques for enhancing the selectivity and efficacy of therapeutic polymers against a broad spectrum of pathogens and cancer cell lines. According to an embodiment, a method is provided that comprises forming a therapeutic polymer based on polymerization of a plurality of therapeutic monomers, wherein the therapeutic polymer provides a therapeutic functionality. The method further comprises attaching biotin to the therapeutic polymer, resulting in a biotin-functionalized therapeutic polymer, wherein the biotin-functionalized therapeutic polymer provides greater therapeutic efficacy relative to the therapeutic polymer.
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公开(公告)号：US10561146B2
公开(公告)日：2020-02-18
申请号：US15824250
申请日：2017-11-28
发明人： Willy Chin , James L. Hedrick , Noah Frederick Fine Nathel , Victoria A. Piunova , Zhi Xiang Voo , Yi Yan Yang
摘要： Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.
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6.发明申请公开(公告)号：US20220054652A1
公开(公告)日：2022-02-24
申请号：US17516861
申请日：2021-11-02
发明人： James L. Hedrick , Nathaniel H. Park , Yi Yan Yang , Zhi Xiang Voo , Jeremy Tan
摘要： Techniques regarding the transportation of molecular cargo across the BBB are provided. For example, one or more embodiments described herein can comprise a chemical compound to facilitate molecular encapsulation of the molecular cargo. The chemical compound can comprise a diblock copolymer having a molecular backbone comprising a polycarbonate structure and a polyethylene glycol structure. Also, the polycarbonate structure can be functionalized with boronic acid.
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公开(公告)号：US20200155686A1
公开(公告)日：2020-05-21
申请号：US16198556
申请日：2018-11-21
发明人： Mareva B. Fevre , James L. Hedrick , Ashlynn Lee , Nathaniel H. Park , Rudy J. Wojtecki , Yi Yan Yang , Zhi Xiang Voo
IPC分类号： A61K47/34 , B01J13/10 , A61K9/107 , A61K31/69 , C08L69/00 , C08L71/02 , C08G81/00 , C08G64/42 , C08G64/18 , C08G65/337
摘要： The subject matter of this invention relates to hydrogel compositions and, more particularly, to hydrogel compositions comprising block copolymers (BCPs) capable of self-assembly into nanoparticles for the delivery and controlled release of therapeutic cargos.
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公开(公告)号：US20200146296A1
公开(公告)日：2020-05-14
申请号：US16738517
申请日：2020-01-09
发明人： Victoria A. Piunova , Noah Frederick Fine Nathel , James L. Hedrick , Yi Yan Yang , Willy Chin , Zhi Xiang Voo
摘要： Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.
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公开(公告)号：US20190159456A1
公开(公告)日：2019-05-30
申请号：US15824250
申请日：2017-11-28
发明人： Willy Chin , James L. Hedrick , Noah Frederick Fine Nathel , Victoria A. Piunova , Zhi Xiang Voo , Yi Yan Yang
IPC分类号： A01N47/06 , C08G64/42 , C09D5/14 , C09D169/00
摘要： Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.
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公开(公告)号：US12036236B2
公开(公告)日：2024-07-16
申请号：US17507170
申请日：2021-10-21
IPC分类号： A61K31/765 , A61K31/155 , C08K5/31 , C08L69/00
CPC分类号： A61K31/765 , A61K31/155 , C08K5/31 , C08L69/00
摘要： Compositions and methods regarding antimicrobial guanidinium macromolecules with one or more targeting moieties for selectively targeting bacteria are provided. According to an embodiment, an antimicrobial macromolecule is provided that comprises a polymer backbone and one or more guanidinium moieties that extend from the polymer backbone. The antimicrobial macromolecule further comprises a targeting moiety that extends from the polymer backbone. The targeting moiety can comprise a substance favored for consumption by bacteria, such as a monosaccharide.
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