公开(公告)号：US08288374B2

公开(公告)日：2012-10-16

申请号：US12921569

申请日：2009-03-11

申请人： Masataka Ihara ,  Jian-Feng Ge ,  Chika Arai ,  Nasser Saad Mohamed Ismail ,  Mei Yang ,  Isamu Itoh ,  Reto Brun

发明人： Masataka Ihara ,  Jian-Feng Ge ,  Chika Arai ,  Nasser Saad Mohamed Ismail ,  Mei Yang ,  Isamu Itoh ,  Reto Brun

IPC分类号： C07D413/12 ,  C07D417/12 ,  A61K31/538

CPC分类号： A61K31/538 ,  C07D265/34 ,  C07D413/12 ,  C07D417/12 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/421

摘要： Provided is a medicinal composition, in particular, a medicinal composition for treatment and/or prevention which has a high therapeutic effect on infection with a parasitic protozoa and a selective toxicity thereto and exhibits a life-prolonging effect and so on. A medicinal composition which contains as the active ingredient a benzo[a]phenoxazine compound represented by General formula (1) or a salt compound of the same, in particular, an agent for treating and/or preventing infection with a protozoa such as malaria, leishmaniasis, African trypanosomiasis, Chagas disease, toxoplasmosis, lymphatic filariasis, babesiosis or coccidium disease; and a novel compound which is contained therein as the active ingredient.

摘要翻译： 本发明提供一种药物组合物，特别是用于治疗和/或预防的药物组合物，其对寄生原虫感染和对其的选择性毒性具有高治疗效果并且具有延长寿命等。 作为活性成分含有由通式（1）表示的苯并[a]吩恶嗪化合物或其盐化合物的药物组合物，特别是用于治疗和/或预防感染原虫如疟疾的药剂， 利什曼病，非洲锥虫病，恰加斯病，弓形虫病，淋巴丝虫病，宝贝病或球虫病; 和作为活性成分含有的新化合物。

公开(公告)号：US5612840A

公开(公告)日：1997-03-18

申请号：US248334

申请日：1994-05-24

申请人： Sinji Hiraoka ,  Yoshihisa Matsumoto ,  Isamu Itoh ,  Shigeo Terashima

发明人： Sinji Hiraoka ,  Yoshihisa Matsumoto ,  Isamu Itoh ,  Shigeo Terashima

IPC分类号： G11B5/60 ,  G11B5/48 ,  G11B21/21

CPC分类号： G11B5/486 ,  G11B5/4833

摘要： A magnetic head unit is provided by which damage to a conductive-pattern layer formed on a spring arm during a bending process of the spring arm can be prevented. The magnetic head unit comprises a magnetic head and a spring arm having a bent portion which is bent to generate an elastic force. The magnetic head is mounted on an end of the spring arm. At least one conductive-pattern layer is formed on a surface of the spring arm to extend from a gimbal portion where the magnetic head is mounted to a attachment portion where the spring arm is mounted to a member of a magnetic head driving mechanism. The bent portion has a first portion and a second portion separated from the first portion. The conductive-pattern layer passes through the second portion. No external force is applied to the conductive-pattern layer formed during a bending process for the bent portion. A dispersing-pattern layer may be provided for dispersing an external force exerted on the conductive-pattern layer during the bending process of the bent portion so that said conductive-pattern layer is protected from being damaged due to the external force being concentrated onto said conductive-pattern layer.

摘要翻译： 提供一种磁头单元，可以防止在弹簧臂的弯曲过程中在弹簧臂上形成的导电图案层的损坏。 磁头单元包括磁头和具有弯曲部分以产生弹力的弯曲部分的弹簧臂。 磁头安装在弹簧臂的一端。 至少一个导电图案层形成在弹簧臂的表面上，从安装磁头的万向节部分延伸到安装弹簧臂的安装部分到磁头驱动机构的构件上。 弯曲部分具有与第一部分分离的第一部分和第二部分。 导电图案层通过第二部分。 对于弯曲部分的弯曲处理期间形成的导电图案层没有施加外力。 可以提供分散图案层，用于在弯曲部分的弯曲过程期间分散施加在导电图案层上的外力，使得所述导电图案层由于外力被集中到所述导电层上而被损坏 图案层。

公开(公告)号：US4845020A

公开(公告)日：1989-07-04

申请号：US77545

申请日：1987-07-24

申请人： Isamu Itoh ,  Keiji Mihayashi

发明人： Isamu Itoh ,  Keiji Mihayashi

IPC分类号： G03C5/29 ,  G03C1/34 ,  G03C7/30 ,  G03C7/305 ,  G03C7/392

CPC分类号： G03C7/305 ,  G03C1/34 ,  Y10S430/158 ,  Y10S430/161

摘要： A method of processing a silver halide photographic material comprising processing the silver halide photographic material in the presence of an antifoggant which is an organic compound which loses its developing restraining function by a reduction oxidation reaction with oxidized developers. The method improves the discrimination between image and non-image areas of the silver halide photographic material by the novel antifoggant which restrains fog selectively in non-image areas without decreasing photographic sensitivity and image density. The organic compound can be an anti-foggant which possesses a moiety according to the Kendall-Pelz rule and either a mercapto group or a cyclic NH group.

摘要翻译： 一种处理卤化银照相材料的方法，包括在防氧化剂存在下处理卤化银照相材料，该防灰雾剂是通过与氧化显影剂的还原氧化反应而失去其显影抑制功能的有机化合物。 该方法通过新的防雾剂改善了卤化银照相材料的图像和非图像区域之间的区别，其在非图像区域中选择性地抑制雾而不降低照相感光度和图像密度。 有机化合物可以是具有根据肯德尔 - 佩尔斯规则的部分和巯基或环状NH基团的防雾剂。

公开(公告)号：US4740453A

公开(公告)日：1988-04-26

申请号：US813308

申请日：1985-12-24

申请人： Koki Nakamura ,  Shigeo Hirano ,  Tadashi Ikeda ,  Keiji Mihayashi ,  Mitsunori Ono ,  Toshiro Takahashi ,  Ken-ichi Kuwabara ,  Morio Yagihara ,  Isamu Itoh

发明人： Koki Nakamura ,  Shigeo Hirano ,  Tadashi Ikeda ,  Keiji Mihayashi ,  Mitsunori Ono ,  Toshiro Takahashi ,  Ken-ichi Kuwabara ,  Morio Yagihara ,  Isamu Itoh

IPC分类号： G03C1/43 ,  G03C7/305 ,  G03C1/40 ,  G03C5/54

CPC分类号： G03C1/43 ,  G03C7/305 ,  G03C2005/168 ,  Y10S430/156 ,  Y10S430/158 ,  Y10S430/16

摘要： A silver halide photosensitive material is described, comprising a support and at least one silver halide emulsion layer, wherein said emulsion layer or another layer contains a compound represented by formula (I) ##STR1## wherein X represents an atomic group forming a redox center of benzene type having substituents by linking with C.sub.A and C.sub.B, and which does not enable Time-PUG to be released until the redox center is oxidized during development processing; EWG represents an electron withdrawing group having a Hammet's .sigma. para value exceeding 0.3; C.sub.A and C.sub.B each represents a carbon atom; R.sub.1 and R.sub.2 each represents a hydrogen atom or a suitable substituent; Time represents a timing group connecting to C.sub.B through a sulfur, nitrogen, or selenium atom thereof, t is an integer of 0 or 1, and when t=0, Time is a chemical bond; PUG represents a photographically useful group and connects to C.sub.B through a sulfur, nitrogen, or selenium atom thereof when t=0; and n is an integer of 0 or 1.

摘要翻译： 描述了卤化银感光材料，其包括载体和至少一种卤化银乳剂层，其中所述乳剂层或另一层含有由式（I）表示的化合物（I），其中X表示形成 通过与CA和CB连接而具有取代基的苯类氧化还原中心，并且不能使Time-PUG释放直到氧化还原中心在显影处理期间被氧化; EWG代表Hammet sigma值超过0.3的吸电子基团; CA和CB各自表示碳原子; R1和R2各自表示氢原子或适当的取代基; 时间表示通过其硫，氮或硒原子与CB连接的定时基团，t为0或1的整数，当t = 0时，为化学键; PUG表示当t = 0时，通过其硫，氮或硒原子连接CB; n为0或1的整数。

公开(公告)号：US4618563A

公开(公告)日：1986-10-21

申请号：US641101

申请日：1984-08-15

申请人： Mitsunori Ono ,  Isamu Itoh ,  Keiji Mihayashi

发明人： Mitsunori Ono ,  Isamu Itoh ,  Keiji Mihayashi

IPC分类号： G03C7/26 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D417/12 ,  G03C1/06 ,  G03C7/00 ,  G03C7/305 ,  G03C8/08 ,  G03C8/10 ,  G03C1/40 ,  G03C1/08 ,  G03C1/34 ,  G03C5/54

CPC分类号： G03C7/30511 ,  G03C8/10 ,  Y10S430/156 ,  Y10S430/158 ,  Y10S430/159 ,  Y10S430/16

摘要： A silver halide photographic light-sensitive material is described, comprising a support having thereon a light-sensitive silver halide emulsion layer having associated therewith a blocked photographic agent represented by formula (I) ##STR1## wherein A represents a photographically useful agent moiety, which may have a timing group; X.sup.1 and X.sup.2 each represents a carbonyl group, a sulfonyl group, or a sulfinyl group; Z represents an atomic group forming a 5-membered, 6-membered, or 7-membered ring; R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen atom, a halogen atom, an alkyl group, an alkenyl group, a cycloalkyl group, an aryl group, an alkoxy group, an acyl group, a sulfonyl group, or a heterocyclic group; R.sup.3 represents an alkyl group, an alkenyl group, a cycloalkyl group, a heterocyclic group, an aryl group, or an aralkyl group; m represents 0, 1, or 2; n represents 0 or 1; and the total of m+n is 1, 2, or 3. The precursor of photographic agent is completely stable during the preservation of the photographic light-sensitive material and releases a photographically useful agent at a desired time during processing of the photographic light-sensitive material. The precursor can exhibit its function to a substantial degree under mild conditions, such as in a pH range of from 9 to 12.

摘要翻译： 描述了一种卤化银照相感光材料，其包括其上具有感光卤化银乳剂层的载体，其具有与式（I）表示的封闭的感光剂相关联，其中A表示摄影有用的试剂部分，其中 可能有一个时间组; X1和X2各自表示羰基，磺酰基或亚磺酰基; Z表示形成5元，6元或7元环的原子团; R 1和R 2可以相同或不同，各自表示氢原子，卤素原子，烷基，烯基，环烷基，芳基，烷氧基，酰基，磺酰基， 或杂环基; R3表示烷基，烯基，环烷基，杂环基，芳基或芳烷基; m表示0,1或2; n表示0或1; 并且m + n的总和为1,2或3.照相剂的前体在照相感光材料的保存期间是完全稳定的，并且在照相感光材料的处理期间在期望的时间释放照相用的试剂， 敏感材料。 前体可以在温和条件下，例如在9至12的pH范围内显着地发挥其功能。

公开(公告)号：US4554246A

公开(公告)日：1985-11-19

申请号：US541649

申请日：1983-10-13

申请人： Kiyohiko Yamamuro ,  Yasuo Iwasa ,  Isamu Itoh

发明人： Kiyohiko Yamamuro ,  Yasuo Iwasa ,  Isamu Itoh

IPC分类号： C07D257/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/10 ,  G03C1/34 ,  G03C1/06 ,  G03C1/84 ,  G03C7/26

CPC分类号： C07D257/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/10 ,  G03C1/346 ,  Y10S430/156

摘要： A photographic silver halide light-sensitive material is described. The material includes at least one of the compounds represented by general formula (I) as described below, their salts, and their precursors releasing the compounds of general formula (I) on cleavage under alkali conditions. ##STR1## (the symbols are as defined in the appended claims). This light-sensitive material is less subject to a variation in photographic performance during the storage, in particular, the formation of fog is prevented.

摘要翻译： 描述了一种感光卤化银感光材料。 所述材料包括如下所述的通式（I）表示的化合物中的至少一种，它们的盐及其在碱性条件下裂解时释放通式（I）的化合物的前体。 （符号如所附权利要求中所定义）。 这种感光材料在存储期间较少受到照相性能的变化的影响，特别是防止形成雾。

公开(公告)号：US4525450A

公开(公告)日：1985-06-25

申请号：US592486

申请日：1984-03-23

申请人： Isamu Itoh ,  Takeshi Hirose

发明人： Isamu Itoh ,  Takeshi Hirose

IPC分类号： C07D231/52 ,  G03C7/32 ,  G03C7/00 ,  G03C1/40

CPC分类号： C07D231/52 ,  G03C7/3212

摘要： A silver halide color photographic light-sensitive material containing a coupler having at least one of a sulfamoylphenylenesulfonyl group, a sulfamoylaminophenylenesulfonyl group and a sulfonamidophenylenesulfonyl group as a substituent. Preferred couplers are represented by the formula: ##STR1## wherein all moieties are defined in the specification wherein Cp is a coupler residue, L is a divalent linking group and X represents --NHSO.sub.2 --, ##STR2## or --SO.sub.2 NH, and n represents 0-4. Groups R.sup.1, R.sup.2 and R.sup.3 are defined in the specification.

摘要翻译： 含有具有磺酰氨基苯磺酰基，氨磺酰氨基苯磺酰基和磺酰氨基苯磺酰基中的至少一种作为取代基的成色剂的卤化银彩色照相感光材料。 优选的成色剂由下式表示：其中所有部分在说明书中定义，其中Cp是成色剂残基，L是二价连接基团，X表示-NHSO 2 - ， - 或SO 2 NH，n表示0 -4。 组R1，R2和R3在说明书中定义。

公开(公告)号：US4508816A

公开(公告)日：1985-04-02

申请号：US544155

申请日：1983-10-21

申请人： Kiyohiko Yamamuro ,  Shigeo Hirano ,  Isamu Itoh ,  Yasuo Iwasa

发明人： Kiyohiko Yamamuro ,  Shigeo Hirano ,  Isamu Itoh ,  Yasuo Iwasa

IPC分类号： C07D257/04 ,  C07D285/12 ,  C07D285/125 ,  G03C7/42 ,  G03C7/00 ,  G03C5/44

CPC分类号： C07D257/04 ,  C07D285/125 ,  G03C7/421

摘要： An improved method for bleaching color photosensitive materials with a persulfate is provided. This method is free of offensive odors, can bleach efficiently color photosensitive materials containing a large amount of silver by using a persulfate, and can effectively bleach color photosensitive materials having colloidal silver layers by using a persulfate. The color photosensitive material used in the present invention contains at least one of the compounds represented by the formula I, salts thereof and precursors thereof: ##STR1## where R.sup.1 and R.sup.2 each independently represents a hydrogen atom, or an aliphatic residue and R.sup.1 and R.sup.2 may form a ring together with the N atom; R.sup.3 represents --R.sup.4 -- or --R.sup.4 --S, said --R.sup.4 -- being a divalent aliphatic residue; and X represents a divalent heterocyclic ring residue containing at least one atom selected from the group consisting of a nitrogen atom, an oxygen atom, and a sulfur atom.

摘要翻译： 提供了一种用过硫酸盐漂白色彩感光材料的改进方法。 该方法没有恶臭，可以通过使用过硫酸盐有效地漂白含有大量银的感光材料，并且可以通过使用过硫酸盐有效地漂白具有胶体银层的彩色感光材料。 本发明中使用的着色光敏材料含有至少一种式I表示的化合物及其盐及其前体：其中R 1和R 2各自独立地表示氢原子，或脂族残基和R 1 R2可以与N原子一起形成环; R3表示-R4-或-R4-S，所述-R4-为二价脂族残基; X表示含有至少一个选自氮原子，氧原子和硫原子的原子的二价杂环残基。

公开(公告)号：US4139320A

公开(公告)日：1979-02-13

申请号：US824614

申请日：1977-08-15

申请人： Toshiyuki Ueno ,  Isamu Itoh ,  Yasuyuki Morita

发明人： Toshiyuki Ueno ,  Isamu Itoh ,  Yasuyuki Morita

IPC分类号： E02D17/08 ,  E21B7/00 ,  E21D9/00 ,  E21D9/04 ,  E21D9/08 ,  E21D9/087 ,  E01G3/00

CPC分类号： E21B7/005 ,  E21D9/005

摘要： A process for excavating and constructing a tunnel, and an excavating device are disclosed. This process is directed to excavating and constructing a tunnel under a railway or a road on a bank or on level land in the direction transverse to the railway or road. In this process, pits are dug on the opposite sides of the railway, and then an excavator digs into the wall of a pit on one side so as to go out of the wall of the other pit through the ground left therebetween. In this respect, a hollow casing unit of a box shape is coupled to the rear end of the excavator equipped with a screw conveyor. As the excavator advances or digs forward a given distance, another casing unit is in turn coupled to the rear end of the preceding casing unit, and then such a step is repeated, until the excavator goes out of the wall of another pit. In this manner, the excavator further digs into the wall of one pit in the position adjacent to the preceding run of casing units. Then, these runs of casing units are placed around the imaginary contour of a tunnel, thereby forming the outer wall of the tunnel. The sand and soil inside the outer wall of the tunnel are excavated and removed, after which reinforcing steel bars and a mold are placed along the inner surface of the wall of the tunnel. Concrete is then poured into the hollow casing units themselves as well as between the mold and the wall. Thus, the hollow casing units form an integral part of the wall of a tunnel, as an outer wall.

摘要翻译： 公开了挖掘和构造隧道的方法和挖掘装置。 这个过程是针对在铁路或公路上，沿着横跨铁路或道路的方式，在银行或者平地上挖掘和建造隧道。 在这个过程中，在铁路的相对侧挖出坑，然后挖掘机在一侧挖入坑的墙壁，以便通过其间留下的地面离开另一坑的墙壁。 在这方面，箱形的中空的壳体单元联接到装有螺旋输送机的挖掘机的后端。 当挖掘机向前进或向前挖一定距离时，另一个壳体单元又与前一个壳体单元的后端连接，然后重复这样一个步骤，直到挖掘机离开另一个坑的壁。 以这种方式，挖掘机进一步在与前一运行的套管单元相邻的位置上进入一个凹坑的壁。 然后，将这些套管单元的运行放置在隧道的假想轮廓周围，从而形成隧道的外壁。 隧道外壁内的沙土被挖出去除，之后加固钢筋和模具沿着隧道的墙壁的内表面放置。 然后将混凝土倒入中空的壳体单元本身以及模具和壁之间。 因此，中空的壳体单元形成作为外壁的隧道的壁的一体部分。

公开(公告)号：US20110021450A1

公开(公告)日：2011-01-27

申请号：US12921569

申请日：2009-03-11

申请人： Masataka Ihara ,  Jian-Feng Ge ,  Chika Arai ,  Mei Yang ,  Isamu Itoh ,  Reto Brun

发明人： Masataka Ihara ,  Jian-Feng Ge ,  Chika Arai ,  Mei Yang ,  Isamu Itoh ,  Reto Brun

IPC分类号： A61K31/7048 ,  C07D265/34 ,  A61K31/538 ,  A61P33/02 ,  A61P33/06 ,  A61K31/555

CPC分类号： A61K31/538 ,  C07D265/34 ,  C07D413/12 ,  C07D417/12 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/421

摘要： Provided is a medicinal composition, in particular, a medicinal composition for treatment and/or prevention which has a high therapeutic effect on infection with a parasitic protozoa and a selective toxicity thereto and exhibits a life-prolonging effect and so on. A medicinal composition which contains as the active ingredient a benzo[a]phenoxazine compound represented by General formula (1) or a salt compound of the same, in particular, an agent for treating and/or preventing infection with a protozoa such as malaria, leishmaniasis, African trypanosomiasis, Chagas disease, toxoplasmosis, lymphatic filariasis, babesiosis or coccidium disease; and a novel compound which is contained therein as the active ingredient.

摘要翻译： 本发明提供一种药物组合物，特别是用于治疗和/或预防的药物组合物，其对寄生原虫感染和对其的选择性毒性具有高治疗效果并且具有延长寿命等。 作为活性成分含有由通式（1）表示的苯并[a]吩恶嗪化合物或其盐化合物的药物组合物，特别是用于治疗和/或预防感染原虫如疟疾的药剂， 利什曼病，非洲锥虫病，恰加斯病，弓形虫病，淋巴丝虫病，宝贝病或球虫病; 和作为活性成分含有的新化合物。