摘要:
Acylamido-3-cephem-4-carboxylic acid compounds of the formula ##STR1## in which the index n represents an integer of from 1 to 4,the index m represents 0 or 1,X represents oxygen, sulphur or an --NH-- group,W represents a --CO--, --CO--NHSO.sub.2 -- or --SO.sub.2 NH--CO-- group, orX-W together represent a --CO-- or --CO--NHSO.sub.2 -- group,A represents optionally substituted phenylene, thienylene or furylene,Y represents hydrogen, hydroxyl, formyloxy, amino or sulpho optionally present in salt form, andZ represents hydrogen, orY andZ together represent an oxo group or an .dbd.N--O--R.sup.o group in which R.sup.o represents hydrogen or optionally substituted lower alkyl,R.sub.1 represents hydrogen, lower alkyl, lower alkoxy, halogen or a group of the formula --CH.sub.2 --R.sub.2 in which R.sub.2 is a free, esterified or etherified hydroxy or mercapto group or a quaternary ammonium group, andR.sub.3 represents hydrogen or methoxy,wherein the carboxyl groups are optionally esterified in a form that can be split under physiological conditions, and the salts thereof, are obtained by liberating the functional group(s) in a starting compound of the formula I in which at least one of the functional groups present is protected.The compounds are effective in vitro and in vivo against gram-positive and gram-negative bacteria and cocci.
摘要:
6.beta.-(R.sub.a)(R.sub.b)N-methylaryl-acetylamino-6.alpha.-methoxy-2,2-dimethylpenam-3-carboxylic acid compounds and 7.beta.-(R.sub.a)(R.sub.b)N-methylaryl-acetylamino-7.alpha.-methoxy-3-cephem-4-carboxylic acid compounds, wherein R.sub.a and R.sub.b independently of each other represent hydrogen or optionally substituted lower alkyl, or wherein R.sub.a and R.sub.b conjointly denote optionally substituted lower alkylene, wherein the aminomethyl-substituted aryl radical represents a corresponding thienyl, furyl or phenyl radical, and wherein the 3-position in 3-cephem compounds is unsubstituted or substituted by a modified hydroxyl group or an optionally substituted methyl group, exhibit antibiotic action against Gram-negative or Gram-positive micro-organisms.
摘要:
A hierarchially arranged memory system is described for a data processing system having virtual addressing. A three-level working memory is provided, along with an auxiliary memory, in a data processing system containing a secondary buffer between the main memory and a rapid buffer memory. Whereas the main memory contains all actual storage areas, i.e. the memory pages of the inactive processes which were required for the processing period just passed, the actual storage area for the successor process, independent from the operating system, is set independently by its own microprocessor.
摘要:
A tack device for holding plaque against blood vessel walls in treating atherosclerotic occlusive disease is formed as a thin, annular band of durable, flexible material having a plurality of focal elevating elements on its outer annular periphery for holding loose plaque under a spring or other expansion force against a blood vessel wall. The focal elevating elements are designed to exert a holding force on a plaque position while minimizing the amount of material surface area in contact with the plaque or blood vessel wall and reducing the potential of friction with the intraluminal surface. This approach offers clinicians the ability to perform a minimally invasive post-angioplasty treatment and produce a stent-like result without using a stent.
摘要:
A security device includes a body housing having a receptacle configured to receive a coupler to affix the body housing to an article of merchandise; a locking mechanism configured to maintain the coupler in a fixed position with respect to the body housing and in retaining engagement with the article of merchandise; and an electro-mechanical actuator configured to alter from a first state to a second state in response to application of an actuation voltage, wherein alteration of the electro-mechanical actuator from the first state to the second state enables the coupler to move with respect to the body housing.
摘要:
A system and method for processing a database query is described. In response to detection that a database query involves a star or snowflake join operation, a join operator in a preliminary query plan can be split into a build operator and a probe operator. The probe operator can be placed in a final query plan in the same place as the join operator in the preliminary query plan, while the build operator can be placed beneath the probe operator in the final query plan, between an exchange operator and the exchange operator's child from the preliminary query plan.
摘要:
Creation of an index for a table of sorted data for use by a data storage application is initiated. Thereafter, N+1 logical partition of rows of the table are defined so that each logical partition has a corresponding worker process. Each worker process then builds a sub-index based on the corresponding logical partition which are later merged to form the index. Related apparatus, systems, techniques and articles are also described.
摘要:
Described are a series of 2-pyridone compounds as a potent and selective new class of type II topoisomerase inhibitors with broad-spectrum antimicrobial activity having the general formula (I); where R1, R2, X, and Y are defined herein Such compounds can be used in methods for treating an infection caused by a gram-positive pathogen, a gram-negative pathogen, or a drug-resistant strains thereof.
摘要:
A transponder having a transmitting and receiving device for receiving commands and transmitting data and command processor for executing commands, and a programming device for changing the memory contents, and a data memory which has a first memory area and a second memory area, whereby the first memory area has the first value or a second value, and when the first memory area has the first value, the content of both memory areas can be changed and, in the case of read access to the second memory area, the transmitting/receiving device transmits a predefined or no data stream instead of the memory content of the second memory area.