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    Esterified hydroxy dihydropyridinones for treating diseases associated with trivalent metal ion overload
    2.
    发明授权
    Esterified hydroxy dihydropyridinones for treating diseases associated with trivalent metal ion overload 失效
    用于治疗与三价金属离子超载相关的疾病的酯化羟基二氢吡啶酮

    公开(公告)号：US4908371A

    公开(公告)日：1990-03-13

    申请号：US265646

    申请日：1988-11-01

    Applicant: Theophile Moerker ,  Heinrich Peter

    Inventor： Theophile Moerker ,  Heinrich Peter

    IPC: A61K31/435 ,  A61P7/00 ,  A61P31/00 ,  A61P33/02 ,  A61P43/00 ,  C07D213/69

    CPC classification number: C07D213/69

    Abstract: 3-Substituted 4(1H)-pyridone compounds of formula ##STR1## wherein R.sub.1 is an unsubstituted or substituted hydrocarbon radical, X is a bond or a group of formula --O-- or --N(R.sub.3)--, wherein R.sub.3 is hydrogen or an unsubstituted or substituted hydrocarbon radical, and R.sub.2 is an unsubstituted or substituted hydrocarbon radical, or wherein R.sub.2 and R.sub.3, when taken together, are an unsubstituted or substituted divalent hydrocarbon radical, and wherein the other ring carbon atoms of the 4(1H)-pyridinone ring, independently of one another, are unsubstituted or substituted by an unsubstituted or substituted hydrocarbon radical or by etherified or esterified hydroxy, and salts of compounds of formula I with salt-forming properties, form chelate-type metal complexes, especially with trivalent metal ions, and can be used, for example, as pharmacologically active compounds.

    Abstract translation: 3-取代的式（I）的4（1H） - 吡啶酮化合物，其中R 1是未取代或取代的烃基，X是式-O-或-N（R 3） - 的键或基团，其中R 3 是氢或未取代或取代的烃基，R 2是未取代或取代的烃基，或其中当R 2和R 3一起为未取代或取代的二价烃基时，其中R 4和R 4的其它环碳原子 1H） - 吡啶酮环，彼此独立地是未取代的或被未取代或取代的烃基或醚化或酯化的羟基取代或具有成盐性的式I化合物的盐形成螯合型金属络合物，特别是 具有三价金属离子，并且可以用作例如药理活性化合物。

    Heteroarylacetamido cephalosporin
    3.
    发明授权
    Heteroarylacetamido cephalosporin 失效
    杂芳基乙酰氨基头孢菌素

    公开(公告)号：US4024249A

    公开(公告)日：1977-05-17

    申请号：US561444

    申请日：1975-03-24

    Applicant: Beat Muller ,  Heinrich Peter ,  Peter Schneider ,  Hans Bickel

    Inventor： Beat Muller ,  Heinrich Peter ,  Peter Schneider ,  Hans Bickel

    IPC: C07D307/52 ,  C07D307/54 ,  C07D333/22 ,  C07D333/24 ,  C07D501/20

    CPC classification number: C07D307/54 ,  C07D307/52 ,  C07D333/22 ,  C07D333/24 ,  Y02P20/55

    Abstract: Novel aminomethyl compounds of the formula ##STR1## wherein X denotes sulphur or oxygen, R denotes hydrogen or an amino protective group, R.sub.1 denotes hydrogen, a free, etherified or esterified hydroxyl group or mercapto group or a substituted ammonium group, R.sub.2 denotes hydroxyl or a carboxyl protective radical which together with the carbonyl grouping of the formula -C(=0)- forms a protected carboxyl group, and their salts, are antibacterial antibiotics or intermediates for the preparation thereof; pharmaceutical preparations containing such active compounds, are useful for combating micro-organisms such as gram-positive or gram-negative bacteria; An illustrative example is 3-acetoxymethyl-7.beta.-[2-(5-aminomethyl-2-thienyl)-acetylamino]-ceph-3-em-4-carboxylic acid.

    Abstract translation: 式（I）的新型氨基甲基化合物其中X表示硫或氧，R表示氢或氨基保护基，R 1表示氢，游离的醚化或酯化的羟基或巯基或 取代的铵基，R2表示羟基或羧基保护基，其与式-C（= O） - 的羰基一起形成被保护的羧基，其盐为抗菌抗生素或其制备的中间体; 含有这种活性化合物的药物制剂可用于对抗微生物如革兰氏阳性或革兰氏阴性细菌; 示例性实例是3-乙酰氧基甲基-7β-[2-（5-氨基甲基-2-噻吩基） - 乙酰氨基] - 头孢-3-烯-4-羧酸。

    Pasty washing agent
    5.
    发明授权
    Pasty washing agent 有权
    美味清洗剂

    公开(公告)号：US06627592B1

    公开(公告)日：2003-09-30

    申请号：US09857741

    申请日：2001-06-08

    Applicant: Khalil Shamayeli ,  Thomas Merz ,  Edgar Koppelmann ,  Heinrich-Peter Furitsch

    Inventor： Khalil Shamayeli ,  Thomas Merz ,  Edgar Koppelmann ,  Heinrich-Peter Furitsch

    IPC: C11D3395

    CPC classification number: C11D3/48 ,  C11D1/04 ,  C11D1/72 ,  C11D3/2086 ,  C11D3/3947 ,  C11D17/003

    Abstract: The invention relates to a pasty washing agent for use in commercial laundering which contains a non-ionic surfactant, an organic and/or inorganic builder, a bleaching agent based on peroxygen, and optionally contains other common constituents. The inventive pasty washing agent is characterized in that it contains 30 wt. % to 60 wt. % of non-ionic surfactant, 0.5 wt. % to 5 wt. % of a fatty acid and/or fatty acid alkaline-salt, 5 wt. % to 15 wt. % of citrate and/or citric acid and 15 wt. % to 35 wt. % of an inorganic peroxygen compound. In addition, the pasty washing agent does not contain alkali metasilicate nor a bleach activator. In addition to exhibiting a good cleaning efficiency, the inventive agent has a disinfecting action.

    Abstract translation: 本发明涉及一种用于商业洗涤的糊状洗涤剂，其包含非离子表面活性剂，有机和/或无机助洗剂，基于过氧化物的漂白剂，并且任选地含有其它共同组分。 本发明的糊状洗涤剂的特征在于它含有30wt。 ％至60重量％ ％的非离子表面活性剂，0.5wt。 ％至5wt。 ％的脂肪酸​​和/或脂肪酸碱盐，5wt。 ％至15wt。 柠檬酸盐和/或柠檬酸的百分比和15重量％ ％〜35重量％ ％的无机过氧化合物。 此外，糊状洗涤剂不含碱金属硅酸盐或漂白活化剂。 除了表现出良好的清洁效率之外，本发明的试剂还具有消毒作用。

    8-Oxo-5-thia-1-azabicyclo(4,2,0)oct-2-ene compounds
    7.
    发明授权
    8-Oxo-5-thia-1-azabicyclo(4,2,0)oct-2-ene compounds 失效
    8-氧代-5-硫杂-1-氮杂双环（4,0,0）辛-2-烯化合物

    公开(公告)号：US4430498A

    公开(公告)日：1984-02-07

    申请号：US227832

    申请日：1981-01-23

    Applicant: Karl Heusler ,  Hans Bickel ,  Bruno Fechtig ,  Heinrich Peter ,  Riccardo Scartazzini

    Inventor： Karl Heusler ,  Hans Bickel ,  Bruno Fechtig ,  Heinrich Peter ,  Riccardo Scartazzini

    IPC: A61K31/545 ,  C07D501/18 ,  C07D501/20

    CPC classification number: C07D501/20 ,  C07D501/18 ,  Y02P20/55

    Abstract: The invention concerns 7-amino-ceph-3-em-4-carboxylic acid compounds of the formula ##STR1## wherein R.sub.1.sup.a represents hydrogen or an amino protective group R.sub.1.sup.A and R.sub.1.sup.b represent hydrogen or an acyl group Ac, or R.sub.1.sup.A and R.sub.1.sup.b together denote a bivalent amino protective group, and R.sub.2 represents hydrogen or an organic radical R.sub.2.sup.A which together with the --C(.dbd.O)--O-- grouping forms a protected carboxyl group, or salts such compounds which possess salt-forming groups; these compounds have antibiotic properties.

    Abstract translation: 本发明涉及下式的7-氨基 - 头孢-3-烯-4-羧酸化合物，其中R 1a表示氢或氨基保护基R1A和R 1b表示氢或酰基Ac或R 1A和 R1b一起表示二价氨基保护基，R2表示氢或与-C（= O）-O-基团一起形成保护的羧基的有机基团R2A，或具有成盐基团的盐的盐; 这些化合物具有抗生素特性。

    Cephalosporins having an .alpha.-acylaminoacetic acid side chain
    9.
    发明授权
    Cephalosporins having an .alpha.-acylaminoacetic acid side chain 失效
    具有{60-酰氨基乙酸侧链的头孢菌素

    公开(公告)号：US4041161A

    公开(公告)日：1977-08-09

    申请号：US576398

    申请日：1975-05-09

    Applicant: Karoly Kocsis ,  Heinrich Peter ,  Hans Bickel

    Inventor： Karoly Kocsis ,  Heinrich Peter ,  Hans Bickel

    IPC: A23K20/195 ,  C07D285/12 ,  C07D285/135 ,  C07D501/20 ,  C07D501/36 ,  A61K31/38 ,  C07D501/32 ,  C07D501/54

    CPC classification number: C07D285/135 ,  C07D501/20

    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 denotes optionally substituted phenyl, thienyl, furyl or 1,4-cyclohexadienyl, R.sub.2 represents a free carboxyl group or an esterified carboxyl group which can be split physiologically, R.sub.3 represents hydrogen, lower akoxy or an optionally substituted methyl group and B represents an optionally substituted six-membered ring with 1 to 3 ring nitrogen atoms, which is bonded to the carbonyl group --C(.dbd.O)-- by one of its carbon atoms, the nitorgen atoms of a monocyclic six-membered ring having 2 nitrogen atoms being either adjacent or separated by two ring carbon atoms, and the salts of such compounds which have a salt-forming group, including the inner salts, for example the 7.beta.-[D(-)-.alpha.-(3,5-Dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamido)-phenylacetamido]-cephalosporanic acid, have antibiotic activity.

    Abstract translation: 其中R 1表示任选取代的苯基，噻吩基，呋喃基或1,4-环己二烯基的化合物，R 2表示可以在生理上分裂的游离羧基或酯化羧基，R 3表示氢，低级烷氧基或任选地 取代的甲基，B表示具有1至3个环氮原子的任选取代的六元环，其通过其一个碳原子与羰基-C（= O） - 键合，单环六 - 具有2个氮原子的2元环与两个环碳原子相邻或分开，并且具有成盐基团的化合物的盐，包括内盐，例如7β-[D（ - ） - （3,5-二氧代-2,3,4,5-四氢-1,2,4-三嗪-6-甲酰氨基） - 苯甲酰胺基] - 头孢烷酸具有抗生素活性。

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