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    Variants derived from ACTRIIB and uses therefor
    34.
    发明申请
    Variants derived from ACTRIIB and uses therefor 有权
    衍生自ACTRIIB的变体并用于此

    公开(公告)号：US20090005308A1

    公开(公告)日：2009-01-01

    申请号：US12012652

    申请日：2008-02-04

    Applicant: John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

    Inventor： John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

    IPC: A61K38/00 ,  C07K14/00 ,  A61P31/00 ,  C07K16/18

    CPC classification number: C07K14/71 ,  A61K38/00 ,  C07K14/705 ,  C07K14/72 ,  C07K16/18 ,  C07K2319/30 ,  C07K2319/70

    Abstract: In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.

    Abstract translation: 在某些方面，本发明提供用于调节（促进或抑制）组织如骨，软骨，肌肉，脂肪和/或神经元组织的生长的组合物和方法。 本发明还提供筛选调节ActRIIB蛋白和/或ActRIIB配体的活性的化合物的方法。 本文提供的组合物和方法可用于治疗与ActRIIB蛋白和/或ActRIIB配体的异常活性相关的疾病。

    Lefty, Lefty derivatives and uses thereof
    35.
    发明申请
    Lefty, Lefty derivatives and uses thereof 有权
    Lefty，Lefty衍生物及其用途

    公开(公告)号：US20070042958A1

    公开(公告)日：2007-02-22

    申请号：US11479181

    申请日：2006-06-30

    Applicant: John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

    Inventor： John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

    IPC: A61K38/17 ,  C07K14/705 ,  C07H21/04 ,  C12P21/06

    CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/495

    Abstract: The disclosure relates to Lefty derivatives and the uses of Lefty polypeptides as antagonists of the function of certain ligands such as Nodal, GDF-8 (Myostatin), and GDF-11. These derivatives may be fused to other functional heterologous proteins such as IgG, especially the Fc portion of IgG. According to the disclosure, Lefty polypeptides are useful in the treatment of a variety of disorders, including, for example, neuronal diseases, muscle and bone conditions, and metabolic disorders.

    Abstract translation: 本公开涉及Lefty衍生物和Lef多肽作为某些配体如Nodal，GDF-8（Myostatin）和GDF-11功能的拮抗剂的用途。 这些衍生物可以与其它功能异源蛋白如IgG，特别是IgG的Fc部分融合。 根据该公开内容，Lefty多肽可用于治疗各种疾病，包括例如神经元疾病，肌肉和骨骼状况以及代谢紊乱。

    Methods for increasing thermogenic adipocytes
    38.
    发明授权
    Methods for increasing thermogenic adipocytes 有权
    增加产热脂肪细胞的方法

    公开(公告)号：US08703694B2

    公开(公告)日：2014-04-22

    申请号：US13403657

    申请日：2012-02-23

    Applicant: John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

    Inventor： John Knopf ,  Jasbir Seehra ,  Ravindra Kumar

    IPC: A61K38/00 ,  C07K16/46

    CPC classification number: C07K16/40 ,  A61K31/7088 ,  A61K38/00 ,  A61K38/1796 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P21/00 ,  C07K14/71 ,  C07K2319/30 ,  C12N5/0602

    Abstract: In certain aspects, the present invention provides compositions and methods for increasing thermogenic adipocytes (e.g., brown adipocytes or other UCP-1 expressing adipocytes) by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, anti-Nodal, anti-activin, and anti-GDF 11 antibodies. A variety of metabolic and other disorders may be treated by causing an increase in thermogenic adipocytes.

    Abstract translation: 在某些方面，本发明提供通过施用ActRIIB信号传导途径的拮抗剂来增加产热脂肪细胞（例如，棕色脂肪细胞或其他表达UCP-1的脂肪细胞）的组合物和方法。 这些拮抗剂的实例包括ActRIIB多肽，抗ActRIIB抗体，抗肌生成抑制素抗体，抗GDF3抗体，抗-Nodal，抗激活素和抗GDF11抗体。 可以通过引起生热脂肪细胞的增加来治疗各种代谢和其它疾病。

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