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    Polyhydroxyalkylpyrazine derivatives, their preparation and the medicaments comprising them
    36.
    发明授权
    Polyhydroxyalkylpyrazine derivatives, their preparation and the medicaments comprising them 有权
    聚羟基烷基吡嗪衍生物，其制备方法和包含它们的药物

    公开(公告)号：US06362185B1

    公开(公告)日：2002-03-26

    申请号：US09483939

    申请日：2000-01-14

    申请人： Georges Bashiardes ,  Jean-Christophe Carry ,  Michel Evers ,  Bruno Filoche ,  Serge Mignani

    发明人： Georges Bashiardes ,  Jean-Christophe Carry ,  Michel Evers ,  Bruno Filoche ,  Serge Mignani

    IPC分类号： A61K314965

    CPC分类号： A61K31/495 ,  C07D241/12

    摘要： The present invention relates to medicaments comprising at least one compound of formula: wherein either R1 represents a —CH(Ra)—CHOH—CHOH—CH2OH chain and R2 represents a —CH2—CHOH—CHOH—CH2OH chain, or R1 represents a —CHOH—CHF—CHOH—CH2OH chain and R2 represents a —CH2—CHF—CHOH—CH2OH chain, or R1 represents a —CHOH—CHOH—CHOH—Rb chain and R2 represents a —CH2—CHOH—CHOH—Rb chain, or R1 represents a —CH2—CHOH—CHOH—CH2OH chain and R2 represents a —CH2—CHOH—CHOH—CH2OH chain, or R1 and R2 are identical and each represent a —(CHOH)n—CH2OH chain in which n is equal to 1, 2, 3 or 4, Ra represents an alkoxy radical (1-6 C in a straight or branched chain) or a fluorine atom, and Rb represents a carboxyl, —CO—NH2 or —CH2—NH2 radical, or one of their stereoisomers or their salts with an inorganic or organic acid, to novel compounds of formula (I) and to their preparation.

    摘要翻译： 本发明涉及包含至少一种下式的化合物的药物：其中R1表示-CH（Ra）-CHOH-CHOH-CH2OH链，R2表示-CH2-CHOH-CHOH-CH2OH链，或R1表示-CHOH- CHF-CHOH-CH2OH链，R2表示-CH2-CHF-CHOH-CH2OH链，或R1表示-CHOH-CHOH-CHOH-Rb链，R2表示-CH2-CHOH-CHOH-Rb链，或R1表示 -CH 2 -CHOH-CHOH-CH 2 OH链，R 2表示-CH 2 -CHOH-CHOH-CH 2 OH链，或R 1和R 2相同，各自表示其中n等于1的 - （CHOH）n -CH 2 OH链， 2,3或4中，Ra表示烷氧基（直链或支链中1-6C）或氟原子，Rb表示羧基，-CO-NH2或-CH2-NH2基，或其立体异构体或 它们与无机或有机酸的盐，与式（I）的新型化合物及其制备。