公开(公告)号：US5987357A

公开(公告)日：1999-11-16

申请号：US903313

申请日：1997-07-30

申请人： David Prutchi ,  Patrick J. Paul

发明人： David Prutchi ,  Patrick J. Paul

IPC分类号： A61N1/362 ,  A61N1/375 ,  H01L25/065 ,  H01L25/07 ,  H01L25/18

CPC分类号： A61N1/375 ,  H01L25/0657 ,  H01L2224/05554 ,  H01L2224/32145 ,  H01L2224/32225 ,  H01L2224/48091 ,  H01L2224/48137 ,  H01L2224/48145 ,  H01L2224/48147 ,  H01L2224/48227 ,  H01L2224/49175 ,  H01L2224/73265 ,  H01L2225/06506 ,  H01L2225/0651 ,  H01L2225/06555 ,  H01L2225/06562 ,  H01L24/73 ,  H01L2924/01019 ,  H01L2924/14

摘要： A memory device particularly useful in size-constrained electronic products, such as cardiac stimulators. To provide additional memory for such size-constrained products, memory chips are stacked one on top of another. The memory chips are configured to facilitate bonding without crossed contacts, using aligned bonding pads, vias, or castellations. Each memory chip also includes an address selection circuit that receives signals from one or more address lines to selectively enable and disable the memory chips in the stack.

公开(公告)号：US5814088A

公开(公告)日：1998-09-29

申请号：US824454

申请日：1997-03-26

申请人： Patrick J. Paul ,  David Prutchi

发明人： Patrick J. Paul ,  David Prutchi

IPC分类号： A61N1/08 ,  A61N1/37

CPC分类号： A61N1/3706 ,  A61N2001/083

摘要： A method and apparatus for detecting failure or impending failure of a lead and for providing a warning to a patient or a patient's physician. The impedance of the lead is repeatedly measured and compared with certain impedance limits. If the measured impedance falls outside of these impedance limits, an alarm may be given to the patient, or a warning may be given to the patient's physician.

摘要翻译： 一种用于检测引线的故障或即将发生故障并用于向患者或患者医师提供警告的方法和装置。 重复测量引线的阻抗并与某些阻抗限制进行比较。 如果测量的阻抗超出这些阻抗限制，则可能会向患者发出警报，或者可能会向患者的医生发出警告。

公开(公告)号：US5730125A

公开(公告)日：1998-03-24

申请号：US712280

申请日：1996-09-11

申请人： David Prutchi ,  Patrick J. Paul

发明人： David Prutchi ,  Patrick J. Paul

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1459 ,  A61M37/00 ,  A61N1/365 ,  A61N1/372 ,  A61N1/375 ,  A61N5/08

CPC分类号： A61N1/375 ,  A61B5/1459 ,  A61N1/36557 ,  A61N1/36585 ,  A61B5/0031

摘要： An implantable medical device, such as a cardiac pacer, defibrillator or drug delivery system, includes a container housing the required power source and circuitry and a header portion molded or glued to the container housing. Sensors, including physiological parameter sensors as may be necessary to control and implement the operation of the implantable device, or a telemetry link, or both, are disposed and sealed within the header. The header may include electromagnetic focusing devices to enhance the performance of the sensors. The sensors may include two pulse oximetry sensors that provide differential measurements to improve detection of arterial blood flow.

公开(公告)号：US5722998A

公开(公告)日：1998-03-03

申请号：US475491

申请日：1995-06-07

申请人： David Prutchi ,  Patrick J. Paul ,  David G. Genzer

发明人： David Prutchi ,  Patrick J. Paul ,  David G. Genzer

IPC分类号： A61F2/02 ,  A61N1/372 ,  A61N1/36

CPC分类号： A61N1/37217 ,  A61F2250/0002 ,  A61N1/3718

摘要： An implantable medical device includes a giant magnetoresistance ratio (GMR) sensor is used to detect the presence of a magnet in order to command the device to enter a predetermined mode of operation. The GMR responds to a modulated magnetic field generated by the programming of a command transmitter apparatus for non-invasive programming or controlling of the implanted device. The implantable medical device also monitors for the presence of a steady magnetic field to place the implanted device in a known, safe mode.

摘要翻译： 可植入医疗装置包括巨磁阻比（GMR）传感器来检测磁体的存在，以便指令装置进入预定的操作模式。 GMR响应通过用于无创编程或控制植入装置的命令发射装置的编程而产生的调制磁场。 可植入医疗装置还监测是否存在稳定的磁场以将植入的装置置于已知的安全模式中。

公开(公告)号：US5713935A

公开(公告)日：1998-02-03

申请号：US697454

申请日：1996-08-23

申请人： David Prutchi ,  Patrick J. Paul ,  D. Curtis Deno

发明人： David Prutchi ,  Patrick J. Paul ,  D. Curtis Deno

IPC分类号： A61N1/365 ,  A61N1/37

CPC分类号： A61N1/36521

摘要： A method and apparatus for monitoring balanced biphasic current pulses used for measuring impedance in cardiac stimulators involves detecting imbalances between the pulses of opposite polarity. Such imbalances are potentially harmful to cardiac stimulator users. By converting the two different pulse phases into potentials, a determination can be made as to whether adequately balanced pulses are being generated. If an imbalance is detected, corrective action can be taken quickly enough to avoid harmful effects to the stimulator user.

摘要翻译： 用于监测用于测量心脏刺激器中的阻抗的平衡双相电流脉冲的方法和装置涉及检测相反极性的脉冲之间的不平衡。 这种不平衡对心脏刺激器使用者可能是有害的。 通过将两个不同的脉冲相位转换为电位，可以确定是否产生足够平衡的脉冲。 如果检测到不平衡，可以快速采取纠正措施，以避免对刺激器用户造成有害影响。

公开(公告)号：US5713931A

公开(公告)日：1998-02-03

申请号：US700585

申请日：1996-09-16

申请人： Patrick J. Paul ,  David Prutchi

发明人： Patrick J. Paul ,  David Prutchi

IPC分类号： A61N1/37

CPC分类号： A61N1/3708

摘要： A method and apparatus for detecting loss of cardiac pacing pulse amplitude includes a comparator for comparing the actual pulse voltage to a reference voltage. In one advantageous embodiment, the reference voltage is determined as a percentage of the programmed pulse amplitude. The comparison of the reference voltage and the actual voltage is latched at the time when a pulse is actually created to produce a signal indicative of whether the amplitude of the actual pulse exceeds the reference. When the amplitude falls below the reference, the system may take corrective action.

摘要翻译： 用于检测心脏起搏脉搏幅度的损失的方法和装置包括用于将实际脉冲电压与参考电压进行比较的比较器。 在一个有利的实施例中，参考电压被确定为编程的脉冲幅度的百分比。 参考电压和实际电压的比较在实际产生脉冲以产生指示实际脉冲的幅度是否超过参考的信号时被锁存。 当幅度低于参考值时，系统可能会采取纠正措施。

公开(公告)号：US5697958A

公开(公告)日：1997-12-16

申请号：US475489

申请日：1995-06-07

申请人： Patrick J. Paul ,  David Prutchi

发明人： Patrick J. Paul ,  David Prutchi

IPC分类号： A61N1/37 ,  G01R29/08 ,  A61N1/16

CPC分类号： G01R29/0814 ,  A61N1/37 ,  A61N1/3718 ,  Y10S128/901

摘要： Disclosed are apparatus and method for detecting electromagnetic interference (EMI), or noise, that may disrupt the proper operation of medical devices implantable in patients, such as cardiac stimulators. Circuitry of the detector of the invention is independent of other circuitry of the medical device. EMI is magnetically induced on an antenna that may be within the metal housing of the device in a receiver circuit, and the EMI signals are output to the noise detector. A variety of alert signals may be provided to the medical device circuitry to warn of the presence of EMI so that appropriate responses may be taken to insure the safety of the patient dependent on the device. The detector may share the telemetry antenna of the medical device, or utilize a separate, dedicated antenna to receive EMI. Alternative antennas external to the metal housing of the medical device include leads from the device to the heart of the patient, and a dedicated antenna in the non-metal header of the device.

摘要翻译： 公开了用于检测可能破坏可植入患者（例如心脏刺激器）的医疗装置的适当操作的电磁干扰（EMI）或噪声的装置和方法。 本发明的检测器的电路与医疗装置的其它电路无关。 EMI可以在可能在接收器电路中的器件的金属外壳内的天线上被磁感应，并且EMI信号被输出到噪声检测器。 可以向医疗设备电路提供各种警报信号以警告EMI的存在，从而可以采取适当的响应来确保取决于设备的患者的安全性。 检测器可以共享医疗设备的遥测天线，或者利用单独的专用天线来接收EMI。 医疗设备的金属外壳外部的替代天线包括从设备到患者心脏的引线，以及设备的非金属接头中的专用天线。

公开(公告)号：US5628776A

公开(公告)日：1997-05-13

申请号：US426949

申请日：1995-04-21

申请人： Patrick J. Paul ,  David Prutchi

发明人： Patrick J. Paul ,  David Prutchi

IPC分类号： A61N1/08 ,  A61N1/37 ,  A61N1/04

CPC分类号： A61N1/3708 ,  A61N1/3706 ,  A61N2001/083

摘要： A cardiac simulation system including a patient warning apparatus. The cardiac stimulator is an implantable pacemaker or defibrillator or combination which can be programmed to automatically alter the voltage of its output stimulus, in particular, to increase the voltage of the output stimulus whenever a condition exists requiring patient notification or warning. A specialized auxiliary lead with a shunt circuit can be connected to a standard socket of a cardiac stimulator header and a standard lead, such as a cardiac pacemaker lead, can then be connected to the auxiliary lead. The auxiliary lead allows a stimulation electrode to be implanted near excitable tissue in a secure fashion to assure stimulation of tissue. The auxiliary lead includes an apparatus for shunting electrical current from the standard stimulation electrode implanted in or near the patient's heart to the auxiliary electrode in the presence of a stimulation pulse with a voltage at or above a preselected level.

摘要翻译： 一种心脏模拟系统，包括患者警告装置。 心脏刺激器是可植入起搏器或除颤器或组合，其可以被编程为自动改变其输出刺激的电压，特别是当存在需要患者通知或警告的状况时增加输出刺激的电压。 具有分流电路的专用辅助引线可以连接到心脏刺激器头部的标准插座，并且诸如心脏起搏器引线的标准引线可以连接到辅助引线。 辅助引线允许刺激电极以可靠的方式植入可兴奋的组织附近以确保对组织的刺激。 辅助引线包括用于在存在具有或高于预选电平的电压的刺激脉冲的情况下将植入在患者心脏中或其附近的标准刺激电极的电流分流到辅助电极的装置。

公开(公告)号：US5609615A

公开(公告)日：1997-03-11

申请号：US532929

申请日：1995-09-22

申请人： Richard S. Sanders ,  Patrick J. Paul ,  David Prutchi

发明人： Richard S. Sanders ,  Patrick J. Paul ,  David Prutchi

IPC分类号： A61N1/08 ,  A61N1/37 ,  A61N1/375

CPC分类号： A61N1/375 ,  A61N1/3708 ,  A61N2001/083

摘要： A cardiac simulator including a patient warning apparatus, having an electrically conductive suture point in electrical communication with the patient warning apparatus. An electrically conductive suture passed through the suture point connects said stimulator mechanically and electrically to excitable tissue such as skeletal tissue. Inside the suture point is a connection for assuring a reliable electrical contact between the suture point and the suture. The cardiac stimulator automatically alters the peak voltage of its output stimulus whenever a condition exists requiring patient notification or warning. A specialized shunt circuit mounted within the stimulator or in the header of the stimulator re-directs electrical current from the standard stimulation electrode to the electrically conductive suture point. A controlled switch may be mounted within a hermetically sealed can of the stimulator to re-direct a stimulation pulse to the suture point. The controlled switch could also be mounted in the header. A dedicated stimulation circuit could also be used. The connection inside the suture point may comprise conductive metal fingers or bristles, a toroidal, multi-filar or woven conductor or an electrically conductive polymer.

摘要翻译： 一种心脏模拟器，包括患者警告装置，具有与患者警告装置电连通的导电缝合点。 通过缝合点的导电缝合线将所述刺激器机械地和电气地连接到可兴奋的组织，例如骨骼组织。 缝合点内部是用于确保缝线点和缝合线之间可靠的电接触的连接。 当需要病人通知或警告的情况下，心脏刺激器会自动改变其输出刺激的峰值电压。 安装在刺激器内或刺激器头部中的专用分路电路将来自标准刺激电极的电流重新引导至导电缝合点。 受控开关可以安装在刺激器的气密密封的罐内以将刺激脉冲重新定向到缝合点。 受控开关也可以安装在头部。 也可以使用专用的刺激电路。 缝合点内的连接可以包括导电金属指或刷毛，环形，多丝或编织导体或导电聚合物。

公开(公告)号：US5609614A

公开(公告)日：1997-03-11

申请号：US549050

申请日：1995-10-27

申请人： Lawrence J. Stotts ,  Patrick J. Paul ,  David Prutchi

发明人： Lawrence J. Stotts ,  Patrick J. Paul ,  David Prutchi

IPC分类号： A61N1/37 ,  A61N1/375 ,  A61N1/36

CPC分类号： A61N1/375 ,  A61N1/3708

摘要： A cardiac simulator including a patient warning apparatus, having a sensor for detecting patient reaction to a warning stimulus and means for adjusting the magnitude of said warning stimulus to obtain a preselected level of reaction. The cardiac stimulator is an implantable pacemaker or defibrillator or combination which can be programmed to produce a warning stimulus whenever a condition exists requiring patient notification or warning. A warning pulse stimulus generator directs electrical current to a warning electrode. Alternatively, a controlled switch may re-direct a stimulation pulse to the warning electrode. The sensor for detecting the reaction of the patient to the applied warning stimulus may be an accelerometer or motion/vibration transducer or other sensor capable of detecting a reaction to a warning stimulus. Means for adjusting the level of the stimulus directed to the patient's skeletal muscle regulate the stimulus until a pre-selected magnitude of reaction has been achieved. The reaction is also maintained below a pre-selected maximum to avoid discomfort to the patient.

摘要翻译： 一种心脏模拟器，其包括具有用于检测患者对警告刺激的反应的传感器的患者警告装置，以及用于调整所述警告刺激的大小以获得预选反应水平的装置。 心脏刺激器是可植入的起搏器或除颤器或组合，每当需要患者通知或警告的情况出现时，可将其编程为产生警告刺激。 警告脉冲刺激发生器将电流引导到警告电极。 或者，受控开关可以将刺激脉冲重新定向到警告电极。 用于检测患者对所施加的警告刺激的反应的传感器可以是能够检测对警告刺激的反应的加速度计或运动/振动换能器或其他传感器。 用于调节针对患者骨骼肌的刺激水平的方法调节刺激，直到达到预先选择的反应程度。 反应也保持在预选的最大值以下，以避免患者的不适。