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31.发明授权Tetrazole compounds and their use as metabotropic glutamate receptor antagonists 失效四唑化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US07691892B2
公开(公告)日：2010-04-06
申请号：US11060463
申请日：2005-02-18
申请人： Martin Johansson , Alexander Minidis , Karin Staaf , David Wensbo , Donald McLeod , Louise Edwards , Methvin Isaac , Anne O'Brien , Abdelmalik Slassi , Tao Xin , Tomislav Stefanac
发明人： Martin Johansson , Alexander Minidis , Karin Staaf , David Wensbo , Donald McLeod , Louise Edwards , Methvin Isaac , Anne O'Brien , Abdelmalik Slassi , Tao Xin , Tomislav Stefanac
IPC分类号： A61K31/41 , C07D257/04
CPC分类号： C07D257/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, R1, R2, m and p, are as defined as in formula I, or, salts, solvates or solvated salts thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
摘要翻译： 本发明涉及新的式I化合物，其中P，Q，X 1，X 2，X 3，X 4，R 1，R 2，m和p如式I中所定义，或其盐，溶剂合物或溶剂化盐， 其制备方法及其制备中使用的新中间体，含有所述化合物的药物组合物和所述化合物在治疗中的用途。
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32.发明授权公开(公告)号：US07476684B2
公开(公告)日：2009-01-13
申请号：US11523717
申请日：2006-09-20
申请人： Alexander Minidis , David Wensbo , Methvin Isaac , Abdelmalik Slassi , Jalaj Arora , Tao Xin , Louise Edwards , Caroline Eriksson , Veronica Profir , Per-Olov Bergstrom
发明人： Alexander Minidis , David Wensbo , Methvin Isaac , Abdelmalik Slassi , Jalaj Arora , Tao Xin , Louise Edwards , Caroline Eriksson , Veronica Profir , Per-Olov Bergstrom
IPC分类号： A61K31/4439 , C07D413/14
CPC分类号： C07D413/14
摘要： The present invention is directed to novel compounds, their use in therapy and pharmaceutical compositions comprising said novel compounds.
摘要翻译： 本发明涉及新化合物，它们在治疗中的用途和包含所述新化合物的药物组合物。
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公开(公告)号：US07456200B2
公开(公告)日：2008-11-25
申请号：US11274611
申请日：2005-11-14
申请人： Jalaj Arora , Louise Edwards , Methvin Isaac , Donald A. McLeod , Abdelmalik Slassi , Tomislav Stefanac , Thomas M. Stormann , David Wensbo , Tao Xin , Helena Gyback , Martin Johansson , Annika Kers , John Malmberg , Alexander Minidis , Karin Oscarsson , Mangus Waldman , Ulrika Yngve , Christoffer Osterwall
发明人： Jalaj Arora , Louise Edwards , Methvin Isaac , Donald A. McLeod , Abdelmalik Slassi , Tomislav Stefanac , Thomas M. Stormann , David Wensbo , Tao Xin , Helena Gyback , Martin Johansson , Annika Kers , John Malmberg , Alexander Minidis , Karin Oscarsson , Mangus Waldman , Ulrika Yngve , Christoffer Osterwall
IPC分类号： A61K31/44 , C07D413/14
CPC分类号： C07D413/14 , C07D413/12 , C07D417/14
摘要： The present invention relates to new compounds of formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing compounds of the formula I and to the use of compounds of the formula I in therapy.
摘要翻译： 本发明涉及新的式I化合物，其制备方法和其中制备的新中间体，含有式I化合物的药物制剂和式I化合物在治疗中的用途。
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34.发明申请5-(Phenylisoxazolylethoxy) - Triazol- 3 -Yl Substituted Pyridine Compounds for the Treatment of Neurological, Psychiatric or Pain Disorders 审中-公开5-（苯基异恶唑基聚乙氧基） - 三唑-3-基取代的吡啶化合物，用于治疗神经，精神或疼痛疾病公开(公告)号：US20080227824A1
公开(公告)日：2008-09-18
申请号：US12067270
申请日：2006-09-20
申请人： Alexander Minidis , David Wensbo , Abdelmalik Slassi , Methvin Isaac , Caroline Ericsson , Veronica Profir , Per-Olov Bergstrom , Louise Edwards , Jalaj Arora , Tao Xin
发明人： Alexander Minidis , David Wensbo , Abdelmalik Slassi , Methvin Isaac , Caroline Ericsson , Veronica Profir , Per-Olov Bergstrom , Louise Edwards , Jalaj Arora , Tao Xin
IPC分类号： A61K31/4525 , C07D413/14 , A61P25/00 , A61P25/14
CPC分类号： C07D413/14
摘要： The present invention is directed to novel compounds of formula (I)/(II)/(III), their use in therapy and pharmaceutical compositions comprising said novel compounds.
摘要翻译： 本发明涉及式（I）/（II）/（III）的新化合物，它们在治疗中的用途和包含所述新化合物的药物组合物。
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35.发明申请ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS 审中-公开其他杂环化合物及其作为代谢谷氨酸受体拮抗剂的使用公开(公告)号：US20070293545A1
公开(公告)日：2007-12-20
申请号：US11840954
申请日：2007-08-18
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/41 , A61K31/44 , A61P25/00 , C07D413/02 , C12N5/00
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译： 本发明涉及新的式I化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
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36.发明申请Poly-heterocyclic compounds and their use as metabotropic glutamate receptor antagonists 审中-公开多杂环化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20070185100A1
公开(公告)日：2007-08-09
申请号：US10588754
申请日：2005-02-17
申请人： Jalaj Arora , Louise Edwards , Methvin Isaac , Annika Kers , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , David Wensbo , Tao Xin , Bjorn Holm
发明人： Jalaj Arora , Louise Edwards , Methvin Isaac , Annika Kers , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , David Wensbo , Tao Xin , Bjorn Holm
IPC分类号： A61K31/535
CPC分类号： C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
摘要： The present invention relates to new compounds of formula (I), wherein P, Q, X1, X2, X3, X4, X5, X6, R1, R2, R3, m, n, and p are as defined as in formula (I), or salts, or hydrates thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
摘要翻译： 本发明涉及新的式（I）化合物，其中P，Q，X 1，X 2，X 3，X 3， X 4，X 5，X 6，R 1，R 2，R 2， 其中，m，n和p如式（I）中所定义，或其盐或其水合物，其制备方法及其制备中使用的新中间体，含有所述化合物的药物组合物和 涉及在治疗中使用所述化合物。
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公开(公告)号：US07074809B2
公开(公告)日：2006-07-11
申请号：US10636977
申请日：2003-08-08
申请人： Jalaj Arora , Louise Edwards , Methvin Isaac , Abdelmalik Slassi , Tomislav Stefanac , David Wensbo , Tao Xin
发明人： Jalaj Arora , Louise Edwards , Methvin Isaac , Abdelmalik Slassi , Tomislav Stefanac , David Wensbo , Tao Xin
IPC分类号： A61K31/44 , C07D401/00
CPC分类号： C07D413/14 , C07D413/04 , C07D417/04 , C07D417/14
摘要： The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, X5, R, R1, R2, R3, R4, R5, G, M1, M2, M3, m and n, are defined as in formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
摘要翻译： 本发明涉及新的式I化合物，其中P，Q，X 1，X 2，X 3，X 3， 4，X 5，R 1，R 1，R 2，R 3，R 3， R 4，R 5，G，M 1，M 2，M 3， m和n定义为式I，其制备方法和其中制备的新中间体，含有所述化合物的药物制剂和所述化合物在治疗中的用途。
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38.发明申请Poly-heterocyclic compounds and their use as metabotropic glutamate receptor antagonists 审中-公开多杂环化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20060025414A1
公开(公告)日：2006-02-02
申请号：US11060561
申请日：2005-02-18
申请人： Jalaj Arora , Louise Edwards , Methvin Isaac , Annika Kers , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , David Wensbo , Tao Xin , Bjorn Holm
发明人： Jalaj Arora , Louise Edwards , Methvin Isaac , Annika Kers , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , David Wensbo , Tao Xin , Bjorn Holm
IPC分类号： A61K31/5377 , A61K31/496 , C07D413/14 , C07D403/14
CPC分类号： C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
摘要： The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4 X5, X6, R1, R2, R3, m, n, and p are as defined as in formula I, or salts, or hydrates thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
摘要翻译： 本发明涉及新的式I化合物，其中P，Q，X 1，X 2，X 3，X 3， 4，X 5，X 6，R 1，R 2，R 3， m，n和p如式I所定义，或其盐或水合物，其制备方法及其制备中使用的新中间体，含有所述化合物的药物组合物，以及使用所述 化合物治疗。
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39.发明申请Tetrazole compounds and their use as metabotropic glutamate receptor antagonists 失效四唑化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20060004021A1
公开(公告)日：2006-01-05
申请号：US11060463
申请日：2005-02-18
申请人： Martin Johansson , Alexander Minidis , Karin Staaf , David Wensbo , Donald McLeod , Louise Edwards , Methvin Isaac , Anne O'Brien , Abdelmalik Slassi , Tao Xin , Tomislav Stefanac
发明人： Martin Johansson , Alexander Minidis , Karin Staaf , David Wensbo , Donald McLeod , Louise Edwards , Methvin Isaac , Anne O'Brien , Abdelmalik Slassi , Tao Xin , Tomislav Stefanac
IPC分类号： A61K31/496 , A61K31/4439 , C07D43/02
CPC分类号： C07D257/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, R1, R2, m and p, are as defined as in formula I, or, salts, solvates or solvated salts thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
摘要翻译： 本发明涉及新的式I化合物，其中P，Q，X 1，X 2，X 3，X 3， R 1，R 2，R 2，m和p如式I中所定义，或其盐，溶剂合物或溶剂化盐，方法 它们的制备方法和用于制备它们的新中间体，含有所述化合物的药物组合物和所述化合物在治疗中的用途。
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公开(公告)号：US20050004130A1
公开(公告)日：2005-01-06
申请号：US10766948
申请日：2004-01-30
申请人： Helena Gyback , Martin Johansson , Alexander Minidis , Gunnar Nordvall , Patrick Raboisson , David Wensbo
发明人： Helena Gyback , Martin Johansson , Alexander Minidis , Gunnar Nordvall , Patrick Raboisson , David Wensbo
IPC分类号： A61K31/498 , A61P25/00 , C07D241/38 , C07D241/44 , C07D241/52 , C07D487/02 , C07D491/04
CPC分类号： C07D241/38 , C07D241/44 , C07D241/52 , C07D491/04
摘要： The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, R1, R2, R3, R4, m and n, are as defined as in formula I, or N1-oxides, salts, solvates or solvated salts thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
摘要翻译： 本发明涉及新的式I化合物，其中P，Q，X 1，X 2，R 1，R 2，R 3，R 4，m和n， 如式I所定义，或其N-氧化物，盐，溶剂合物或溶剂化盐，其制备方法及其制备中使用的新中间体，含有所述化合物的药物组合物和所述化合物在治疗中的用途。
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