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1.发明申请Poly-heterocyclic compounds and their use as metabotropic glutamate receptor antagonists 审中-公开多杂环化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20070185100A1
公开(公告)日：2007-08-09
申请号：US10588754
申请日：2005-02-17
申请人： Jalaj Arora , Louise Edwards , Methvin Isaac , Annika Kers , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , David Wensbo , Tao Xin , Bjorn Holm
发明人： Jalaj Arora , Louise Edwards , Methvin Isaac , Annika Kers , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , David Wensbo , Tao Xin , Bjorn Holm
IPC分类号： A61K31/535
CPC分类号： C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
摘要： The present invention relates to new compounds of formula (I), wherein P, Q, X1, X2, X3, X4, X5, X6, R1, R2, R3, m, n, and p are as defined as in formula (I), or salts, or hydrates thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
摘要翻译： 本发明涉及新的式（I）化合物，其中P，Q，X 1，X 2，X 3，X 3， X 4，X 5，X 6，R 1，R 2，R 2， 其中，m，n和p如式（I）中所定义，或其盐或其水合物，其制备方法及其制备中使用的新中间体，含有所述化合物的药物组合物和 涉及在治疗中使用所述化合物。
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2.发明申请Poly-heterocyclic compounds and their use as metabotropic glutamate receptor antagonists 审中-公开多杂环化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20060025414A1
公开(公告)日：2006-02-02
申请号：US11060561
申请日：2005-02-18
申请人： Jalaj Arora , Louise Edwards , Methvin Isaac , Annika Kers , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , David Wensbo , Tao Xin , Bjorn Holm
发明人： Jalaj Arora , Louise Edwards , Methvin Isaac , Annika Kers , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , David Wensbo , Tao Xin , Bjorn Holm
IPC分类号： A61K31/5377 , A61K31/496 , C07D413/14 , C07D403/14
CPC分类号： C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
摘要： The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4 X5, X6, R1, R2, R3, m, n, and p are as defined as in formula I, or salts, or hydrates thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
摘要翻译： 本发明涉及新的式I化合物，其中P，Q，X 1，X 2，X 3，X 3， 4，X 5，X 6，R 1，R 2，R 3， m，n和p如式I所定义，或其盐或水合物，其制备方法及其制备中使用的新中间体，含有所述化合物的药物组合物，以及使用所述 化合物治疗。
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3.发明申请公开(公告)号：US20080015234A1
公开(公告)日：2008-01-17
申请号：US11840952
申请日：2007-08-18
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/4439 , A61K31/4196 , A61K31/4245 , A61P19/06 , A61P25/18 , A61P25/30 , A61P29/00 , A61P9/00 , C07D413/14 , C12N5/00 , C07D271/06 , A61P35/00 , A61P27/02 , A61P25/28 , A61P25/08 , A61P19/02 , A61K31/443
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
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4.发明申请Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists 失效额外的杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20050272779A1
公开(公告)日：2005-12-08
申请号：US11053752
申请日：2005-02-09
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/4245 , A61K31/4439 , C07D413/14
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译： 本发明涉及新的式I化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
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5.发明申请ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS 审中-公开其他杂环化合物及其作为代谢谷氨酸受体拮抗剂的使用公开(公告)号：US20080045571A1
公开(公告)日：2008-02-21
申请号：US11840953
申请日：2007-08-18
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/4439 , A61K31/4196 , A61K31/4245 , A61P19/06 , A61P25/18 , A61P25/30 , A61P29/00 , A61P9/00 , C07D413/14 , C12N5/00 , C07D271/06 , A61P35/00 , A61P27/02 , A61P25/28 , A61P25/08 , A61P19/02 , A61K31/443
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译： 本发明涉及新的式I化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
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6.发明申请Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists 审中-公开额外的杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20070179188A1
公开(公告)日：2007-08-02
申请号：US10588702
申请日：2005-02-15
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald Mcleod , Alexander Minidis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald Mcleod , Alexander Minidis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/4439 , A61K31/4245 , C07D413/14 , C07D413/02
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula (I), to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译： 本发明涉及新的式（I）化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
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7.发明申请公开(公告)号：US20080015204A1
公开(公告)日：2008-01-17
申请号：US11840955
申请日：2007-08-18
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/519 , A61K31/4196 , A61K31/4245 , A61P19/02 , A61P25/08 , A61P25/28 , A61P27/02 , A61P35/00 , C07D271/06 , C07D487/04 , C07D413/14 , A61P9/00 , A61P29/00 , A61P25/30 , A61P25/18 , A61P19/06 , A61K31/443 , A61K31/4439
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
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8.发明申请ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS 审中-公开其他杂环化合物及其作为代谢谷氨酸受体拮抗剂的使用公开(公告)号：US20070293545A1
公开(公告)日：2007-12-20
申请号：US11840954
申请日：2007-08-18
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/41 , A61K31/44 , A61P25/00 , C07D413/02 , C12N5/00
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译： 本发明涉及新的式I化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
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9.发明授权Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists 失效额外的杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US07585881B2
公开(公告)日：2009-09-08
申请号：US11053752
申请日：2005-02-09
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tau Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tau Xin , Jalaj Arora
IPC分类号： A61K31/4439 , C07D401/14 , C07D413/04
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译： 本发明涉及新的式I化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
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公开(公告)号：US20060122397A1
公开(公告)日：2006-06-08
申请号：US11274611
申请日：2005-11-14
申请人： Jalaj Arora , Louise Edwards , Methvin Isaac , Donald McLeod , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Helena Gyback , Martin Johansson , Annika Kers , John Malmberg , Alexander Minidis , Karin Oscarsson , Mangus Waldman , Ulrika Yngve , Christoffer Osterwall
发明人： Jalaj Arora , Louise Edwards , Methvin Isaac , Donald McLeod , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Helena Gyback , Martin Johansson , Annika Kers , John Malmberg , Alexander Minidis , Karin Oscarsson , Mangus Waldman , Ulrika Yngve , Christoffer Osterwall
IPC分类号： A61K31/4439 , A61K31/4245 , C07D417/14 , C07D413/14 , C07D409/14
CPC分类号： C07D413/14 , C07D413/12 , C07D417/14
摘要： The present invention relates to new compounds of formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
摘要翻译： 本发明涉及新的式I化合物，其制备方法和其中制备的新中间体，含有所述化合物的药物制剂和所述化合物在治疗中的用途。
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